1 research outputs found
Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques
Capping failure, edge chipping, and non-uniform mechanical properties of convexfaced pharmaceutical tablets are common problems in pharma industry. In this paper,
Finite Element Modelling (FEM) and Design of Experiment (DoE) techniques are
adopted to find the optimal shape of convex-faced (CF) pharmaceutical tablet which
has more uniform mechanical properties and less capping and chipping tendency.
The effects of the geometrical parameters and friction on the compaction responses
of convex-faced pharmaceutical tablets were first identified and analysed. The finite
element model of the tabletting process was generated using the implicit code
(ABAQUS) and validated against experimental measurements. Response Surface
Methodology (RSM) was employed to establish the relationship between the design
variables, represented by the geometrical parameters and the friction coefficient, and
compaction responses of interest including residual die pressure, the variation of
relative density within the tablet, and the relative shear stress of the edge of the
tablet. A statistical-based optimisation approach is then employed to undertake shape
optimisation of CF tablets. The obtained results demonstrated how the geometrical
parameters of CF tablet and the friction coefficient have significant effects on the
compaction behaviour and quality of the pharmaceutical tablet