Bounding robustness in complex networks under topological changes through majorization techniques

Measuring robustness is a fundamental task for analyzing the structure of complex networks. Indeed, several approaches to capture the robustness properties of a network have been proposed. In this paper we focus on spectral graph theory where robustness is measured by means of a graph invariant called Kirchhoff index, expressed in terms of eigenvalues of the Laplacian matrix associated to a graph. This graph metric is highly informative as a robustness indicator for several realworld networks that can be modeled as graphs. We discuss a methodology aimed at obtaining some new and tighter bounds of this graph invariant when links are added or removed. We take advantage of real analysis techniques, based on majorization theory and optimization of functions which preserve the majorization order (Schurconvex functions). Applications to simulated graphs show the effectiveness of our bounds, also in providing meaningful insights with respect to the results obtained in the literature

Where Graph Topology Matters: The Robust Subgraph Problem

Robustness is a critical measure of the resilience of large networked systems, such as transportation and communication networks. Most prior works focus on the global robustness of a given graph at large, e.g., by measuring its overall vulnerability to external attacks or random failures. In this paper, we turn attention to local robustness and pose a novel problem in the lines of subgraph mining: given a large graph, how can we find its most robust local subgraph (RLS)? We define a robust subgraph as a subset of nodes with high communicability among them, and formulate the RLS-PROBLEM of finding a subgraph of given size with maximum robustness in the host graph. Our formulation is related to the recently proposed general framework for the densest subgraph problem, however differs from it substantially in that besides the number of edges in the subgraph, robustness also concerns with the placement of edges, i.e., the subgraph topology. We show that the RLS-PROBLEM is NP-hard and propose two heuristic algorithms based on top-down and bottom-up search strategies. Further, we present modifications of our algorithms to handle three practical variants of the RLS-PROBLEM. Experiments on synthetic and real-world graphs demonstrate that we find subgraphs with larger robustness than the densest subgraphs even at lower densities, suggesting that the existing approaches are not suitable for the new problem setting.Comment: 13 pages, 10 Figures, 3 Tables, to appear at SDM 2015 (9 pages only

Protein multi-scale organization through graph partitioning and robustness analysis: Application to the myosin-myosin light chain interaction

Despite the recognized importance of the multi-scale spatio-temporal organization of proteins, most computational tools can only access a limited spectrum of time and spatial scales, thereby ignoring the effects on protein behavior of the intricate coupling between the different scales. Starting from a physico-chemical atomistic network of interactions that encodes the structure of the protein, we introduce a methodology based on multi-scale graph partitioning that can uncover partitions and levels of organization of proteins that span the whole range of scales, revealing biological features occurring at different levels of organization and tracking their effect across scales. Additionally, we introduce a measure of robustness to quantify the relevance of the partitions through the generation of biochemically-motivated surrogate random graph models. We apply the method to four distinct conformations of myosin tail interacting protein, a protein from the molecular motor of the malaria parasite, and study properties that have been experimentally addressed such as the closing mechanism, the presence of conserved clusters, and the identification through computational mutational analysis of key residues for binding.Comment: 13 pages, 7 Postscript figure

Graph measures and network robustness

Network robustness research aims at finding a measure to quantify network robustness. Once such a measure has been established, we will be able to compare networks, to improve existing networks and to design new networks that are able to continue to perform well when it is subject to failures or attacks. In this paper we survey a large amount of robustness measures on simple, undirected and unweighted graphs, in order to offer a tool for network administrators to evaluate and improve the robustness of their network. The measures discussed in this paper are based on the concepts of connectivity (including reliability polynomials), distance, betweenness and clustering. Some other measures are notions from spectral graph theory, more precisely, they are functions of the Laplacian eigenvalues. In addition to surveying these graph measures, the paper also contains a discussion of their functionality as a measure for topological network robustness