Use of Statistical Outlier Detection Method in Adaptive\ud Evolutionary Algorithms

In this paper, the issue of adapting probabilities for Evolutionary Algorithm (EA) search operators is revisited. A framework is devised for distinguishing between measurements of performance and the interpretation of those measurements for purposes of adaptation. Several examples of measurements and statistical interpretations are provided. Probability value adaptation is tested using an EA with 10 search operators against 10 test problems with results indicating that both the type of measurement and its statistical interpretation play significant roles in EA performance. We also find that selecting operators based on the prevalence of outliers rather than on average performance is able to provide considerable improvements to\ud adaptive methods and soundly outperforms the non-adaptive\ud case

Use of statistical outlier detection method in adaptive evolutionary algorithms

In this paper, the issue of adapting probabilities for Evolutionary Algorithm (EA) search operators is revisited. A framework is devised for distinguishing between measurements of performance and the interpretation of those measurements for purposes of adaptation. Several examples of measurements and statistical interpretations are provided. Probability value adaptation is tested using an EA with 10 search operators against 10 test problems with results indicating that both the type of measurement and its statistical interpretation play significant roles in EA performance. We also find that selecting operators based on the prevalence of outliers rather than on average performance is able to provide considerable improvements to adaptive methods and soundly outperforms the non-adaptive case

The Co-Evolution of Sustainable Development and Environmental Justice: Cooperation, Then Competition, Then Conflict

This article explores sustainable development and environmental justice as potentially conflicting policy goals. Sustainable development includes equity as one of its five dimensions (in addition to environment, economy, time, and space), whereas environmental justice focuses principally on equity. Over time there is likely to be an increasing number of contexts in which sustainability-based policy solutions do not satisfy environmental justice advocates

Parameters identification of unknown delayed genetic regulatory networks by a switching particle swarm optimization algorithm

The official published version can be found at the link below.This paper presents a novel particle swarm optimization (PSO) algorithm based on Markov chains and competitive penalized method. Such an algorithm is developed to solve global optimization problems with applications in identifying unknown parameters of a class of genetic regulatory networks (GRNs). By using an evolutionary factor, a new switching PSO (SPSO) algorithm is first proposed and analyzed, where the velocity updating equation jumps from one mode to another according to a Markov chain, and acceleration coefficients are dependent on mode switching. Furthermore, a leader competitive penalized multi-learning approach (LCPMLA) is introduced to improve the global search ability and refine the convergent solutions. The LCPMLA can automatically choose search strategy using a learning and penalizing mechanism. The presented SPSO algorithm is compared with some well-known PSO algorithms in the experiments. It is shown that the SPSO algorithm has faster local convergence speed, higher accuracy and algorithm reliability, resulting in better balance between the global and local searching of the algorithm, and thus generating good performance. Finally, we utilize the presented SPSO algorithm to identify not only the unknown parameters but also the coupling topology and time-delay of a class of GRNs.This research was partially supported by the National Natural Science Foundation of PR China (Grant No. 60874113), the Research Fund for the Doctoral Program of Higher Education (Grant No. 200802550007), the Key Creative Project of Shanghai Education Community (Grant No. 09ZZ66), the Key Foundation Project of Shanghai (Grant No. 09JC1400700), the Engineering and Physical Sciences Research Council EPSRC of the UK under Grant No. GR/S27658/01, the International Science and Technology Cooperation Project of China under Grant No. 2009DFA32050, an International Joint Project sponsored by the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

Simulation, optimization and instrumentation of agricultural biogas plants

During the last two decades, the production of renewable energy by anaerobic digestion (AD) in biogas plants has become increasingly popular due to its applicability to a great variety of organic material from energy crops and animal waste to the organic fraction of Municipal Solid Waste (MSW), and to the relative simplicity of AD plant designs. Thus, a whole new biogas market emerged in Europe, which is strongly supported by European and national funding and remuneration schemes. Nevertheless, stable and efficient operation and control of biogas plants can be challenging, due to the high complexity of the biochemical AD process, varying substrate quality and a lack of reliable online instrumentation. In addition, governmental support for biogas plants will decrease in the long run and the substrate market will become highly competitive. The principal aim of the research presented in this thesis is to achieve a substantial improvement in the operation of biogas plants. At first, a methodology for substrate inflow optimization of full-scale biogas plants is developed based on commonly measured process variables and using dynamic simulation models as well as computational intelligence (CI) methods. This methodology which is appliquable to a broad range of different biogas plants is then followed by an evaluation of existing online instrumentation for biogas plants and the development of a novel UV/vis spectroscopic online measurement system for volatile fatty acids. This new measurement system, which uses powerful machine learning techniques, provides a substantial improvement in online process monitoring for biogas plants. The methodologies developed and results achieved in the areas of simulation and optimization were validated at a full-scale agricultural biogas plant showing that global optimization of the substrate inflow based on dynamic simulation models is able to improve the yearly profit of a biogas plant by up to 70%. Furthermore, the validation of the newly developed online measurement for VFA concentration at an industrial biogas plant showed that a measurement accuracy of 88% is possible using UV/vis spectroscopic probes

Design principles for riboswitch function

Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the construction of tunable regulatory components based on its rich regulatory capacity and our current understanding of the sequence–function relationship. One prominent example of RNA-based regulatory components is riboswitches, genetic elements that mediate ligand control of gene expression through diverse regulatory mechanisms. While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. Here, we combined mathematical modeling and experimental approaches to investigate the relationship between riboswitch function and performance. Model results demonstrated that the competition between reversible and irreversible rate constants dictates performance for different regulatory mechanisms. We also found that practical system restrictions, such as an upper limit on ligand concentration, can significantly alter the requirements for riboswitch performance, necessitating alternative tuning strategies. Previous experimental data for natural and synthetic riboswitches as well as experiments conducted in this work support model predictions. From our results, we developed a set of general design principles for synthetic riboswitches. Our results also provide a foundation from which to investigate how natural riboswitches are tuned to meet systems-level regulatory demands

The economic basis of periodic enzyme dynamics

Periodic enzyme activities can improve the metabolic performance of cells. As an adaptation to periodic environments or by driving metabolic cycles that can shift fluxes and rearrange metabolic processes in time to increase their efficiency. To study what benefits can ensue from rhythmic gene expression or posttranslational modification of enzymes, I propose a theory of optimal enzyme rhythms in periodic or static environments. The theory is based on kinetic metabolic models with predefined metabolic objectives, scores the effects of harmonic enzyme oscillations, and determines amplitudes and phase shifts that maximise cell fitness. In an expansion around optimal steady states, the optimal enzyme profiles can be computed by solving a quadratic optimality problem. The formulae show how enzymes can increase their efficiency by oscillating in phase with their substrates and how cells can benefit from adapting to external rhythms and from spontaneous, intrinsic enzyme rhythms. Both types of behaviour may occur different parameter regions of the same model. Optimal enzyme profiles are not passively adapted to existing substrate rhythms, but shape them actively to create opportunities for further fitness advantage: in doing so, they reflect the dynamic effects that enzymes can exert in the network. The proposed theory combines the dynamics and economics of metabolic systems and shows how optimal enzyme profiles are shaped by network structure, dynamics, external rhythms, and metabolic objectives. It covers static enzyme adaptation as a special case, reveals the conditions for beneficial metabolic cycles, and predicts optimally combinations of gene expression and posttranslational modification for creating enzyme rhythms

Sensor Placement Strategies for the Seismic Monitoring of Complex Vaulted Structures of the Modern Architectural Heritage

Effective diagnostic and monitoring systems are highly needed in the building and infrastructure sector, to provide a comprehensive assessment of the structural health state and improve the maintenance and restoration planning. Vibration-based techniques, and especially ambient vibration testing, have proved to be particularly suitable for both periodic and continuous monitoring of existing structures. As a general requirement, permanent systems must include a sensing network able to run a continuous surveillance and provide reliable analyses based on different information sources. The variability in the environmental and operating conditions needs to be accounted for in designing such a sensor network, but it is mainly the structural typology that governs the optimal sensor placement strategy. Architectural heritage consists of a great variety of buildings and monuments that significantly differ from each other in terms of typology, historic period, construction techniques, and materials. In this paper, the main issues regarding seismic protection and analysis of the modern architectural heritage are introduced and applied to one of the vaulted structures built by Pier Luigi Nervi in the Turin Exhibition Centre. The importance of attaining an adequate level of knowledge in historic structures is also highlighted. After an overview of the Turin Exhibition Centre and its construction innovations, this paper focuses on Hall B, describing the structural design conceived by Pier Luigi Nervi. A seismic assessment of the structures of Hall B is then presented, considering the potential seismic damage to nonstructural elements. Subsequently, the application of an optimal sensor placement strategy is described with reference to two different scenarios: the first one corresponding to the undamaged structure and the second one that considers a possible damage to the infill walls. Finally, a novel damage-scenario-driven sensor placement strategy based on a combination of the two above mentioned is proposed and discussed. One of the major conclusions drawn from the analyses performed is that nonstructural elements undergoing seismic damage or degradation may significantly affect the global dynamic response and consequently the optimal sensing configurations