Joint Bayesian Gaussian discriminant analysis for speaker verification

State-of-the-art i-vector based speaker verification relies on variants of Probabilistic Linear Discriminant Analysis (PLDA) for discriminant analysis. We are mainly motivated by the recent work of the joint Bayesian (JB) method, which is originally proposed for discriminant analysis in face verification. We apply JB to speaker verification and make three contributions beyond the original JB. 1) In contrast to the EM iterations with approximated statistics in the original JB, the EM iterations with exact statistics are employed and give better performance. 2) We propose to do simultaneous diagonalization (SD) of the within-class and between-class covariance matrices to achieve efficient testing, which has broader application scope than the SVD-based efficient testing method in the original JB. 3) We scrutinize similarities and differences between various Gaussian PLDAs and JB, complementing the previous analysis of comparing JB only with Prince-Elder PLDA. Extensive experiments are conducted on NIST SRE10 core condition 5, empirically validating the superiority of JB with faster convergence rate and 9-13% EER reduction compared with state-of-the-art PLDA.Comment: accepted by ICASSP201

Efficient use of single molecule time traces to resolve kinetic rates, models and uncertainties

Single molecule time traces reveal the time evolution of unsynchronized kinetic systems. Especially single molecule F\"orster resonance energy transfer (smFRET) provides access to enzymatically important timescales, combined with molecular distance resolution and minimal interference with the sample. Yet the kinetic analysis of smFRET time traces is complicated by experimental shortcomings - such as photo-bleaching and noise. Here we recapitulate the fundamental limits of single molecule fluorescence that render the classic, dwell-time based kinetic analysis unsuitable. In contrast, our Single Molecule Analysis of Complex Kinetic Sequences (SMACKS) considers every data point and combines the information of many short traces in one global kinetic rate model. We demonstrate the potential of SMACKS by resolving the small kinetic effects caused by different ionic strengths in the chaperone protein Hsp90. These results show an unexpected interrelation between conformational dynamics and ATPase activity in Hsp90.Comment: 17 pages, 6 figure

Rectified Gaussian Scale Mixtures and the Sparse Non-Negative Least Squares Problem

In this paper, we develop a Bayesian evidence maximization framework to solve the sparse non-negative least squares (S-NNLS) problem. We introduce a family of probability densities referred to as the Rectified Gaussian Scale Mixture (R- GSM) to model the sparsity enforcing prior distribution for the solution. The R-GSM prior encompasses a variety of heavy-tailed densities such as the rectified Laplacian and rectified Student- t distributions with a proper choice of the mixing density. We utilize the hierarchical representation induced by the R-GSM prior and develop an evidence maximization framework based on the Expectation-Maximization (EM) algorithm. Using the EM based method, we estimate the hyper-parameters and obtain a point estimate for the solution. We refer to the proposed method as rectified sparse Bayesian learning (R-SBL). We provide four R- SBL variants that offer a range of options for computational complexity and the quality of the E-step computation. These methods include the Markov chain Monte Carlo EM, linear minimum mean-square-error estimation, approximate message passing and a diagonal approximation. Using numerical experiments, we show that the proposed R-SBL method outperforms existing S-NNLS solvers in terms of both signal and support recovery performance, and is also very robust against the structure of the design matrix.Comment: Under Review by IEEE Transactions on Signal Processin