Voluntary movement takes shape. the link between movement focusing and sensory input gating

The aim of the study was to investigate the relationship between motor surround inhibition (mSI) and the modulation of somatosensory temporal discrimination threshold (STDT) induced by voluntary movement. Seventeen healthy volunteers participated in the study. To assess mSI, we delivered transcranial magnetic stimulation (TMS) single pulses to record motor evoked potentials (MEPs) from the right abductor digiti minimi (ADM; “surround muscle”) during brief right little finger flexion. mSI was expressed as the ratio of ADM MEP amplitude during movement to MEP amplitude at rest. We preliminarily measured STDT values by assessing the shortest interval at which subjects were able to recognize a pair of electric stimuli, delivered over the volar surface of the right little finger, as separate in time. We then evaluated the STDT by using the same motor task used for mSI. mSI and STDT modulation were evaluated at the same time points during movement. mSI and STDT modulation displayed similar time-dependent changes during index finger movement. In both cases, the modulation was maximally present at the onset of the movement and gradually vanished over about 200 ms. Our study provides the first neurophysiological evidence about the relationship between mSI and tactile-motor integration during movement execution

Jefferson Digital Commons quarterly report: October-December 2017

This quarterly report includes: Assorted assets added to the JDC in the last quarter Grand Rounds Recordings College Within a College (CWIC) Posters Program of Industrial Design Capstones What people are saying about the JD

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features

Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MSH2 and also MSH6 in families seen to demonstrate an excess of endometrial cancer. As a consequence, tumors in HNPCC reveal alterations in the length of simple repetitive genomic sequences like poly-A, poly-T, CA or GT repeats (microsatellites) in at least 90% of the cases. Aim of the Study: The study cohort consisted of 25 HNPCC index patients ( 19 Amsterdam positive, 6 Bethesda positive) who revealed a microsatellite stable (MSS) - or low instable (MSI-L) - tumor phenotype with negative mutation analysis for the MMR genes MLH1 and MSH2. An extended marker panel (BAT40, D10S197, D13S153, D18S58, MYCL1) was analyzed for the tumors of these patients with regard to three aspects. First, to reconfirm the MSI-L phenotype found by the standard panel; second, to find minor MSIs which might point towards an MSH6 mutation, and third, to reconfirm the MSS status of hereditary tumors. The reconfirmation of the MSS status of tumors not caused by mutations in the MMR genes should allow one to define another entity of hereditary CRC. Their clinical features were compared with those of 150 patients with sporadic CRCs. Results: In this way, 17 MSS and 8 MSI-L tumors were reclassified as 5 MSS, 18 MSI-L and even 2 MSI-H ( high instability) tumors, the last being seen to demonstrate at least 4 instable markers out of 10. Among all family members, 87 malignancies were documented. The mean age of onset for CRCs was the lowest in the MSI-H-phenotyped patients with 40.5 +/- 4.9 years (vs. 47.0 +/- 14.6 and 49.8 +/- 11.9 years in MSI-L- and MSS-phenotyped patients, respectively). The percentage of CRC was the highest in families with MSS-phenotyped tumors (88%), followed by MSI-L-phenotyped ( 78%) and then by MSI-H-phenotyped (67%) tumors. MSS tumors were preferentially localized in the distal colon supposing a similar biologic behavior like sporadic CRC. MSH6 mutation analysis for the MSI-L and MSI-H patients revealed one truncating mutation for a patient initially with an MSS tumor, which was reclassified as MSI-L by analyzing the extended marker panel. Conclusion: Extended microsatellite analysis serves to evaluate the sensitivity of the reference panel for HNPCC detection and permits phenotype confirmation or upgrading. Additionally, it confirms the MSS status of hereditary CRCs not caused by the common mutations in the MMR genes and provides hints to another entity of hereditary CRC. Copyright (C) 2004 S. Karger AG, Basel

Diagnostic value of the Dutch version of the MCclean Screening instrument for BPD (MSI-BPD)

Borderline personality disorder (BPD) often goes unrecognized, and therefore a short but accurate screening tool is desired. The present study investigated the psychometric properties of the 10-item McLean Screening Instrument for BPD (MSI-BPD) in 159 well-diagnosed female participants. The MSI-BPD showed excellent internal consistency (alpha = .90). When compared to BPD diagnoses based on a structured clinical interview (SCID-II), the MSI-BPD showed substantial congruent validity (receiver operating characteristic area under the curve = 0.96). The cutoff point proposed by the developers of the MSI-BPD (7 or more) showed high specificity (.96) and good sensitivity (.71). The optimal cutoff point in the present study (5 or more) showed somewhat lower specificity (.86), but importantly better sensitivity (.94). Taken together, the Dutch version of the MSI-BPD demonstrated good psychometric properties for a screening tool

Jefferson Digital Commons quarterly report: July-September 2017

This quarterly report includes: Assorted articles Confronting Racism, Bias, and Social Injustice in Healthcare Lecture CREATE DAY OT Capstone presentations Grand Rounds Assorted Newsletters Nexus Maximus Posters University Wide Posters House Staff Quality Improvement and Patient Safety Posters CSHLA Scholar Day posters Student publications and presentations What People are Saying about the Jefferson Digital Common

Jefferson Digital Commons quarterly report: April-June 2017

For Full-Text access download report. Jefferson Digital Commons Quarterly Report: April-June 2017 The Jefferson Digital Commons had another very busy quarter with assets being deposited from across the enterprise. Total number of assets deposited this quarter: 371 Total downloads for this quarter: 113,261(April 10, 2017 highest download count: 1,763) 7,500 different institutions accessed content in the JDC Asset with the most downloads this quarter: 2017 issue of Inside Out Countries visiting the JDC this quarter: 196 Below are highlighted assets that were added to the inventory along with more feedback from researchers that continue to arrive from around the globe on the impact of works found in the JDC. If you would like to have content deposited please contact: [email protected], [email protected] or [email protected] Assorted highlighted materials added to the JDC April-June 2017: 9th Annual Faculty Days Design is Not Just for Designers! Use Design Thinking & Interprofessional Hackathon Design Events to Innovate Your Curriculum or Clinical Practice Article: Sonoelastography of the Common Flexor Tendon of the Elbow with Histologic Agreement: A Cadaveric Study Grand Rounds: Mindfulness for Chronic Pain Female Sexual Dysfunction and Problems in the Postmenopausal Woman: How to Help Stella Get her Groove Back Bipolar Disorder for Primary Care Pediatric Palliative Care Epigenetic Approaches to Epithelial Ovarian Cancer Family and Community Medicine Town Hall Dare More, Do More, Live More: Living Fearlessly Beyond Cancer Translational Cancer Research: The Surgeon\u27s Role Post-exposure prophylaxis (PEP) for HIV: A Guide to Use in Primary Care How to run away from Doctors and Hospitals Use of Teratogenic Medicines in Women of Reproductive Age Delirium Attention-Deficit Hyperactivity Disorder: A Biomedical Approach to Diagnosis and Treatment OSA and Primary Snoring: Palatal Surgery and Office-Based Procedures Annular and ovoid lesions: Defining Moments Sports Medicine Update Jonathan Letterman, MD: The Surgeon-Soldier a his Reforms of Battlefield Medicine Statistics for Surgeons Surgical Ergonomics in Otolaryngology Have you created your database yet? Two-year Mortality in Elderly Free Flap Patients: Case-Control Study Metformin effects on head and neck squamous carcinoma microenvironment: window of opportunity trial New Therapies in the Management of Heart Failure Overlapping Surgery in 2017: Understanding the Debate and What\u27s Next Research in the Department of Family and Community Medicine at Thomas Jefferson University Erectile Dysfunction Dysregulation of microRNAs leads to target therapy Diet, Gut, Brain: An Update Screening, Brief Intervention and Referral to Treatment (SBIRT) for Substance Use Disorders The History of Medicine and LGBTQ+ Populations in the United States Hodgkin Lymphoma: Progress Made and Challenges Ahead Breast Cancer Screening in the Modern Age Improving the quality and outcomes of older women\u27s decision-making around breast cancer screening and treatment Templeton Grand Rounds: Mitral Valve Surgery for Functional MR Evaluating Sleep Issues in Primary Care Department of Surgery: The Year in Review and Integration 2.0 (2016-2017 The last week of the fiscal year) Venous Thromboemboli: Should your patient with a DVT be admitted? The Subscapular System of Flaps in Head and Neck Reconstruction Targeting Frailty in Older Patients with Heart Failure: The REHAB-HF Experience Medical Cannabis: Lessons Learned by a Family Doctor Historical Materials: Caps & Capes - Student Nurses Newspaper, 1958-1971 House Staff Quality and Improvement Patient Safety Posters “The Weekend Effect : Weekday versus Weekend comparison of patients admitted with NSTEMI in terms of length of hospital stay, door to balloon time and left ventricular function A Quality Improvement Project to Reduce the Wait Time for Initial Appointment in an Urban Outpatient Sleep Center Journal The Medicine Forum, 2017, Volume 18. Meeting Report: The Value of Cancer Immunotherapy Summit at the 2016 Society for Immunotherapy of Cancer 31st anniversary annual meeting MPH Capstone presentations: Borders and Blood Pressure: Identifying the Association of Acculturation with Hypertension Diagnoses Among Hispanic-American Immigrants Partnerships to Improve Community Health (PICH) Initiative on Nutrition in Wilmington, DE: An Assessment of Fruit and Vegetable Consumption Perceptions of Living with Chronic Illness as Type 2 Diabetic Transgender Adults Addressing Obesity in the Early Head Start Community Through Environmental and Educational Means (Pilot Program) Screening for Adolescent Alcohol and Other Drug Use by Jefferson Providers: Methods, Barriers and Facilitators Self-Reported Prostate Cancer Screening Among Men Aged 45+ in Southeastern Pennsylvania: Trends from 2008-2015 and Correlates from 2015 Shedding Light on Communication Disorders in Syrian Refugee Children Veterans Status and Its Impact on Mental Health, Access, Use, Alcohol Use and Suicide Outcomes of Teen Pregnancies Delivered at University of Texas Medical Branch in 2013 The Impact of Case Management Interventions on Hospital Readmission Rates and Emergency Department Visits Weight Gain in Obese Pregnant Women and Risk for Cesarean Delivery by Class of Obesity Human Rights of Refugees, Immigrants and the Internally Displaced Assessing STD Knowledge and Attitudes of Campus Hookup Culture at Philadelphia University Policy and Public Health Implications for Exchange of Super Protected Data in Pennsylvania A Mixed-Methods Approach to Developing a Short-Form Opioid Abuse Screening Tool Climate Change and Resulting Floods: Using Social Capital to Strengthen Community Resilience in Eastwick, A Known Floodplan Retrospective Cohort Study of Refugee HealthCare Utilization in Philadelphia, 2007-2016 Healthcare utilization patterns among refugees resettled in the United States: A Systematic Review Developing and designing a sustainable evaluative program protocol that aims to deliver affordable quality eye-care to underserved children within the Philadelphia School District Evaluation of the Hit Count as a Concussion Prevention Strategy in a Youth (4-14 years old) Football League: A Grant Proposal Indego Helmet Assessment How Does an Understanding of the Lower Extremity Amputation Patient Population That a Large Urban Podiatric Practice Serves Improve the Care of that Population? Transition to and from the Nursing Home: A Qualitative Study of People Severely Disabled by Multiple Sclerosis and Measurement of Self-Efficacy MS in Applied Health Economics and Outcomes Research: Identification of Cognitively Impaired Patients At Risk For Development of Alzheimer\u27s Disease: An Analysis of US Medicare Claims Data MS in Health Policy: What Bundled Payment Structure Should Physical Therapists Support for Patients After Total Hip and Knee Arthroplasty? Consumer Cost Transparency Initiatives in Pennsylvania MS in Healthcare Quality and Safety: Implementation of Standardized Discharge Rounds as a Tool to Decrease Length of Stay in an Acute Care Hospital Implementation of Standardized Screening for Cognitive Dysfunction at a Multispecialty Group Practice Comparing Effectiveness Between Departments of Initiatives to Improve Stroke Prevention for Atrial Fibrillation Patients A Collaborative Approach to Improving Door-to-Needle Times in Patients with Acute Ischemic Stroke Standardizing the Use of Chlorhexidine Gluconate (CHG) Wipes in the Preoperative Area Prior to Colon, Hysterectomy, Total Hip, and Total Knee Surgery: Does Direct Observation Increase Compliance? News: Jefferson Digital Commons quarterly report: January-March 2017 Conference Posters Archived in the Jefferson Digital Commons Jefferson College of Population Health Capstones New to the Jefferson Digital Commons New Presentations in the Jefferson Digital Commons Newsletters: A Word from the Writing Center (April 2017) A Word from the Writing Center (May 2017) A Word from the Writing Center (June 2017) JCIPE Spring 2017 Inside Out, Spring 2016 Inside Out, Spring 2017 Sci-Tech Newsletter, June 2017 Occupational Therapy student capstones: Improving Sexual Intimacy of Adults with Physical Disabilities Sleep: Its Impact on Health Effects of Alternative Seating in the Classroom Effects of Transition Services for Students with Cerebral Palsy on Employment Podcasts: New Developments in Genetic/Genomic Testing: Implications for Population Health Improving Health Outcomes: Meeting the Basic Needs of Populations Posters: Evaluating Value-Based Frameworks Used for Relapsed or Refractory Multiple Myeloma Regimens: ICER Report, ASCO Value Framework, and NCCN Evidence Blocks Cost Savings and Efficiency Realized Decreasing Orders for Type and Crossmatching ST elevation myocardial infarction in a young adult: Expect the unexpected Looking beyond the traditional: integrating a new curriculum design into an immersion practicum evaluation tool Perceptions of Accelerated Bachelor of Science in Nursing Program Graduates Regarding Andragogical Practices Employed by Faculty Infection Prevention and Control in Baccalaureate Nursing Education: Identifying Content, Teaching Strategies and Gaps Book Club at Intern Orientation to Help Frame Professional Identity Pre-Admission Blood Pressure and Outcome in a Large Telestroke Cohort Socioeconomic Status and Stroke Outcome Increased Density of Axonal Spheroids in the Nucleus Gracilis of the Lower Brainstem in Diabetic Versus Non-Diabetic Patients The Bug-Bag: Consolidating Medications to Cut Costs Generation of CRISPR knockout of IDH1 in pancreatic ductal adenocarcinoma cell line: An optimal model to study pancreatic cancer metabolic reprogramming Evidence in Action: Impact of Early Occupational Therapy Intervention in the Complex Stroke Patient A Comparative Analysis of the Paris System and Institutional Reporting System for Urine Cytology in Upper Tract Urothelial Specimens Treatment-Related Decisional Conflict, Quality of Life, and Comorbid Illness in Older Adults with Cancer Predictors of HPV Vaccination Series Completion in Philadelphia Adolescents Exploring the Role of Life Review Videos with Patients Diagnosed with Advanced Cancer Gathering Qualitative Feedback and Demonstrating Value for an Institutional Repository (IR) Patient Attitudes Toward a Physician Led Radiology Review: Improved Understanding of Medical Conditions and a Potential New Quality Metric Inappropriate electrolyte repletion for patients undergoing endoscopic procedures Assessing the Burden of Unnecessary Central Venous Catheters in Patients on Medical-Surgical Floors The Use of Telemetry Monitoring Among General Medicine Patients Improving Medication Reconciliation Using Provider Education and an EHR Hard Stop Helping to Support CPC+ Initiative to Integrate Behavioral Health Within Primary Care: A Team-Based Approach to Improving Depression Management Lost in Translation: A Standardized, Interdepartmental Approach to Improve the Safety of Inpatient Transitions of Care Under Pressure: Ambulatory Blood Pressure Control Obstacles and Challenges to Implementing Multi-departmental QI at a Large, Academic Training Center-Lessons Learned from a HCV Screening Program Improving Pneumococcal Vaccination Rates in Jefferson Hospital Ambulatory Practice Patients Improving Colon Cancer Screening in a Resident Ambulatory Clinic Got Sugar? Pharmacist Intervention to Improve A1c The Case of the 10 Pound Giant: A Near Miss Root Cause Analysis Should we Set a Formalized Discharge Instruction Education Standard? Presentations: RNA matters lecture series: The Human tRNA Story: A Complex Epigenomic Landscape Unfolds Medicare at 50: Its Effect on Disparities Surgery Resident Research Day Presentations: GCC as a Therapeutic Target in Colorectal Cancer Stem Cells Exploring Complications and Quality of Life Following Paraesophageal Hernia Repair A spoonful of sugar: The role of IDH1 and metabolic reprogramming in pancreatic cancer Multi-institutional Evaluation of Adherence to Comprehensive Postoperative Venous Thromboembolism Chemoprophylaxis Implementing ICOUGH: The Messy Science of Quality Improvement The Effect of a HIF Prolyl Hydroxylase inhibitor on Liver Regeneration after Partial Hepatectomy in Mice Molecular Profiling of Resected Pancreatic Cancer: the Potentia Personalizing Adjuvant Therapy Drug Discovery in Pancreatic Cancer: The Power of the Pathway Approach What People are Saying About the JDC: Country: US Role: faculty Resource URL: http://jdc.jefferson.edu/medfp/153/ Comments: For teaching purpose Name: Betty Patricia Harrell Country: US Role: researcher Resource URL: https://core.ac.uk/download/pdf/46965911.pdf Comments: Too many volumes as I researcher Bricker, William Henry for genealogy I became fascinated by the sciences of the early 1900\u27s and could not stop...Thank you putting them online for free. Name: Leticia Ghelman Country: BR (Brazil) Role: student Resource URL: http://jdc.jefferson.edu/fmfp/7/ Comments: I am a student at Universidade Estacio de Sa- Rio de Janeiro, Brazil, College of Nutrition. We are writing a paper about Nutrition Literacy and would love to have access to the NLS. It would really help us in the development of our work, which is being conducted at a loca government family practice. Thank you in advance Name: Alam Country: AE (United Arab Emirates) Role: student Comments: Good work Referring Page: http://jdc.jefferson.edu/mphcapstone_presentation/143/ Country: US Role: physician, member of antibiotic stewardship comm Comments: good info on use of bandemia in clinical practice http://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1103&context=medfp Name: Lauren Wiseman Country: US Role: Non-profit Regional HIE Resource URL: http://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1002&context=ms_hqs Comments: We are seeking information on medication reconciliation with HIE as we strive to provide valuable use cases for our participants. Name: B. J. Strickland Country: US Role: genealogist Resource URL: http://jdc.jefferson.edu/jmc_catalogs/50/ Comments: Thank you for making this Annual Announcement available. I am in the middle of doing genealogical research on my family. This 1861-1862 Jefferson Medical College annual announcement has my great grandfather\u27s name, Dr. James S. Washington, on the graduate list. This piece of personal history is very rewarding. Thanks again