The orienting mouse: An input device with attitude

This paper presents a modified computer mouse, the Orienting Mouse, which delivers orientation as an additional dimension of input; when the mouse is moved on a flat surface it reports, in addition to the conventional x, y translation, angular rotation of the device in the x, y plane. The orienting mouse preserves important properties of the standard mouse; all measurements are relative and movement is tracked only while the mouse is on its flat surface. If the user lets go of the mouse, leaving it on the surface, its position and orientation do not change until it is touched again. Picking the mouse up and putting it down in a different orientation leaves the angle and position unchanged. While the concept of sensing mouse rotation is not new, our work focuses on movement and navigation in 3D, rather than on precision positioning tasks. We describe a number of sample applications developed to test its effectiveness in this context. Specific features exploited and described include (i) an algorithm for calculating the mouse angle which cancels drift between the two sensors, and (ii) the use of angular gearing which avoids unnatural and uncomfortable hand positions when moving through large angles; informal user testing validates this idea

”PENGARUH BERBAGAI DOSIS FILTRAT DAUN COCOR BEBEK \ud (Kalanchoe pinnata L.) TERHADAP PENURUNAN SUHU TUBUH TIKUS \ud PUTIH (Rattus norvegicus) HIPERTERMIA”

Fever is situation of body temperature above normal as effect of make-up of center arrangement of temperature in hipotalamus which in influencing by IL-I. Fever usually happened effect of body of terpapar infection of mikroorganisme (virus, bacterium, parasite). Fever also can \ud because of factor of[is non infection like immured complex, or inflammation (other peradangan). \ud When bacterium or virus come into body, various phabocyte type or leucocyte discharge “ Iihat vitamin cause of fever (endogen pirogen)” later on trigger production of prostaglandin E2 i] anterior hipotalamus, what later;then improve temperature nilai-ambang and happened by fever. \ud leaf of Cocor bebek (Kalanchoe pinnata L.) functioning as antipiretik. Compound Beta of sitosterol dissolve in blood and structure almost loo like with prostaglandin. \ud This research aim to to know influence various dose of filtrat leaf of cocor parrot to degradat ion of white mouse body temperature and to know most effective dose of leaf filtrat of cocor parrot to degradation of white mouse body temperature. \ud This research is executed in Chemical Laboratory UMM. this Method Research is True Experimental Research, with The Pretest-Posttest Control Group Design, sampling technique of Simple Random Sampling with plan attempt of Complete Random Device, with research sampel 24 white mouse tail of male (8 treatment group by 3 restating times). This research variable, that is free variable: dose of filtrat leaf of cocor parrot, varibel depended: degradation of mouse body temperature, control variable: mouse gender, mouse age, heavy of mouse body, vaccine dose of DPT, condition of white mouse cage, food type, and beverage. Technique data collecting is indirect perception because using materials and appliance. Data is here in after analysed with ANAVA and Test of Duncan’S Bedasarkan result of analysis of varians obtained one way F count > F tables of at level of signifikansi 1% meaning there influence various dose of filtrat leaf of cocor parrot to degradation of white mouse body temperature seen is big degradation of body temperature at perception 6 hour after fever. From result of test of Duncan’S 1% dose of filtrat leaf of cocor parrot most effective degrade mouse body temperature reach its dropsy temperature return group of H (dose of filtrat leaf of cocor parrot 4,5 ml / mouse tail) this result not differ reality with group of B (Parasetamol 0,083 mg / mouse tail). \ud Result of research of menunjukan that Leaf filtrat of cocor parrot can be used as drug of antipiretik effective at dose 4,5 ml / mouse tail after 6 hour consume leaf filtrat of cocor bebek body temperature return normally (dropsy)

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. Results: We find initial evidence for richness-driven, strain-independent murine enterotypes that show a striking resemblance to those in human, and which associate with calprotectin levels, a marker for intestinal inflammation. After enterotype stratification, we find that genetic, caging and inter-individual variation contribute on average 19%, 31.7% and 45.5%, respectively, to the variance in the murine gut microbiota composition. Genetic distance correlates positively to microbiota distance, so that genetically similar strains have more similar microbiota than genetically distant ones. Specific mouse strains are enriched for specific operational taxonomic units and taxonomic groups, while the 'cage effect' can occur across mouse strain boundaries and is mainly driven by Helicobacter infections. Conclusions: The detection of enterotypes suggests a common ecological cause, possibly low-grade inflammation that might drive differences among gut microbiota composition in mammals. Furthermore, the observed environmental and genetic effects have important consequences for experimental design in mouse microbiome research

Mouse models of colorectal cancer.

Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer

EFEK ANALGETIK SARI RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) PADA TIKUS PUTIH (Rattus norvegicus) STRAIN WISTAR

Painful is inconvenience feeling which felt by patient, so that the sigh represent symptom and sign which not too difficult recognized by klinis but its vary cause (Soelistiono, 2004). Painful if body organ, muscle, or skin injure by, disease, have cram, or swelling (Ikawati, 2008). Temulawak (Curcuma xanthorrhiza Roxb) owning two obstetrical group especial chemistry that is faction compound of kurkumin oil and of atsiri functioning as analgetik, because activity of kurkumin oil and of atsiri can pursue to be formed and prostaglandin of leukotrien. This research aim to to know influence of gist rimpang Curcuma to degradation painful respon at white mouse and to know most effective dose gist rimpang curcuma to degradation painful respond white mouse. Research type is True Experimental Research, research desain is The Pretest-Posstest Control Group Design, measuring painful respon use Analgesy-Meter seen the make-up of burden weight generating painful respon. Population is white mouse male (Rattus norvegicus), amount of sampel 25 tail which consist of 5 treatment group by 5 restating times. Technique intake of sampel is Simple Random Sampling. Variable Research, that is free variable: dose gist rimpang temulawak, varibel depended: degradation of painful respon at white mouse, control variable: white mouse (Rattus norvegicus) strain Wistar male sex, age 2 months, heavy mean body 200 gr, condition of white mouse cage, food and beverage type. Research device use Complete Random Device. Analysis Data with ANAVA and Test of Duncan’S. Result research and result analyse obtained one way varians F count > F tables at level of signifikansi 1% showing there influence of gist dose of rimpang temulawak to degradation painful respon white mouse seen the make-up of burden weight generating painful respon at perception 60 minute after treatment. From result test of Duncan’S 1% gist dose of rimpang curcuma most effective degrade painful respon is white mouse group which given treatment dose 1,67 ml / 200grBB, this result differ reality in comparison with group control without treatment, white mouse group which given treatment of dose 1 ml / 200grBB, and white mouse group which given treatment of dose 1,33 ml/200grBB. This matter prove that gist of rimpang curcuma have an effect on to degradation painful respon at white mouse which measured use Analgesy-Meter

Intrusion Detection Using Mouse Dynamics

Compared to other behavioural biometrics, mouse dynamics is a less explored area. General purpose data sets containing unrestricted mouse usage data are usually not available. The Balabit data set was released in 2016 for a data science competition, which against the few subjects, can be considered the first adequate publicly available one. This paper presents a performance evaluation study on this data set for impostor detection. The existence of very short test sessions makes this data set challenging. Raw data were segmented into mouse move, point and click and drag and drop types of mouse actions, then several features were extracted. In contrast to keystroke dynamics, mouse data is not sensitive, therefore it is possible to collect negative mouse dynamics data and to use two-class classifiers for impostor detection. Both action- and set of actions-based evaluations were performed. Set of actions-based evaluation achieves 0.92 AUC on the test part of the data set. However, the same type of evaluation conducted on the training part of the data set resulted in maximal AUC (1) using only 13 actions. Drag and drop mouse actions proved to be the best actions for impostor detection.Comment: Submitted to IET Biometrics on 23 May 201

Reproductive tract biology: Of mice and men.

The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology. For ease of experimentation and economy, the mouse has been used extensively as a model for human development and pathogenesis, and for the most part similarities in developmental processes and hormone action provide ample justification for the relevance of mouse models for human reproductive tract development. Indeed, there are many examples describing the phenotype of human genetic disorders that have a reasonably comparable phenotype in mice, attesting to the congruence between mouse and human development. However, anatomic, developmental and endocrinologic differences exist between mice and humans that (1) must be appreciated and (2) considered with caution when extrapolating information between all animal models and humans. It is critical that the investigator be aware of both the similarities and differences in organogenesis and hormone action within male and female reproductive tracts so as to focus on those features of mouse models with clear relevance to human development/pathology. This review, written by a team with extensive expertise in the anatomy, developmental biology and endocrinology of both mouse and human urogenital tracts, focusses upon the significant human/mouse differences, and when appropriate voices a cautionary note regarding extrapolation of mouse models for understanding development of human male and female reproductive tracts

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28

CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans, thereby implying the existence of distinct signalling abilities between human and mouse CD28. Here, we show that a single amino acid variant within the C-terminal proline-rich motif of human and mouse CD28 (P212 in human vs. A210 in mouse) regulates CD28-induced NF-κB activation and pro-inflammatory cytokine gene expression. Moreover, this Y209APP212 sequence in humans is crucial for the association of CD28 with the Nck adaptor protein for actin cytoskeleton reorganisation events necessary for CD28 autonomous signalling. This study thus unveils different outcomes between human and mouse CD28 signalling to underscore the importance of species difference when transferring results from preclinical models to the bedside