16,150 research outputs found
Probabilistic methods in the analysis of protein interaction networks
Imperial Users onl
Random matrix analysis for gene interaction networks in cancer cells
Investigations of topological uniqueness of gene interaction networks in
cancer cells are essential for understanding this disease. Based on the random
matrix theory, we study the distribution of the nearest neighbor level spacings
of interaction matrices for gene networks in human cancer cells. The
interaction matrices are computed using the Cancer Network Galaxy (TCNG)
database, which is a repository of gene interactions inferred by a Bayesian
network model. 256 NCBI GEO entries regarding gene expressions in human cancer
cells have been selected for the Bayesian network calculations in TCNG. We
observe the Wigner distribution of when the gene networks are dense
networks that have more than edges. In the opposite case, when
the networks have smaller numbers of edges, the distribution becomes the
Poisson distribution. We investigate relevance of both to the size of
the networks and to edge frequencies that manifest reliance of the inferred
gene interactions.Comment: 22 pages, 7 figure
Structural Drift: The Population Dynamics of Sequential Learning
We introduce a theory of sequential causal inference in which learners in a
chain estimate a structural model from their upstream teacher and then pass
samples from the model to their downstream student. It extends the population
dynamics of genetic drift, recasting Kimura's selectively neutral theory as a
special case of a generalized drift process using structured populations with
memory. We examine the diffusion and fixation properties of several drift
processes and propose applications to learning, inference, and evolution. We
also demonstrate how the organization of drift process space controls fidelity,
facilitates innovations, and leads to information loss in sequential learning
with and without memory.Comment: 15 pages, 9 figures;
http://csc.ucdavis.edu/~cmg/compmech/pubs/sdrift.ht
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