197 research outputs found
No Road, No Rage: A Forum on Expanding Bay Area Ferry Service, MTI Report F-02-01
As part of the Mineta Transportation Institute\u27s ongoing efforts to promote dialogue addressing surface transportation issues, it is my pleasure to share this edited transcript of No Road, No Rage: A Forum on Expanding Bay Area Ferry Service . As the title suggests, expanding water transit services has been proposed as one way to ease congestion on the roads. The San Francisco Bay Area Water Transit Authority is seeking to expand ferry service for the Bay Area, and this forum offered an opportunity for interested citizens to hear more about the proposal, ask questions, and share their concerns and hopes. This event was the result of many people\u27s efforts, and I thank all those individuals and organizations referenced in the Acknowledgements section. I especially want to thank George Dobbins, Program Director of The Commonwealth Club, for working with MTI to sponsor this event; Senator Don Perata for being a leader in the legislature on this issue and also for being our keynote speaker; Tom Vacar for taking the time to be our moderator; and our panelists, Steve Kinsey, Russell Long, Cynthia Murray, and Gavin Newsom. The Mineta Transportation Institute has three primary functions: research, education, and information transfer. It is in this last role that we organized and presented this discussion. We hope that this edited transcript will contribute to an understanding of the issues and possible solutions, not only for those in our community, but also for anyone considering water transit issues
Mythcon 3 (Westercon 25)
This Mythcon III program is a double-issue with Westercon 25
Herald of Holiness Volume 62 Number 04 (1973)
01 Cover Photo: Los Angeles Grace Church 02 Life\u27s Unshakables by General Superintendent Strickland 03 From Church to Community by Jack W. Furbee 04 The Believer\u27s Battle by Gaines Glass 04 Father, Send Us by C. Neil Strait 05 Sond Props by Katherine Bevis 06 Brotherhood - A Human Family Experience by John C. Oster 08 What Does It Mean To Preach Christ ? by C. William Fisher 09 Life Is For Looking by by Ross W. Hayslip 10 Lincoln and the Bible by Harold R. Crosser 12 Dear God, What Can I Do For You? by James D. Hamilton 13 Why Christ\u27s Coming Could Be Soon by Fred M. Weatherford 13 Influence by Geraldine Nicholas 14 Revival and Miracles - What About Indonesia? by W. Stanley Mooneyham 16 Witches, Warlocks, And Ouija Boards by Aarlie J. Hull 17 Editorial by W. T. Purkiser 30 News of Religion 31 Answer Cornerhttps://digitalcommons.olivet.edu/cotn_hoh/2289/thumbnail.jp
Systematic Genetic Nomenclature for Type VII Secretion Systems
CITATION: Bitter, W., et al. 2009. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathogens, 5(10): 1-6, doi: 10.1371/journal.ppat.1000507.The original publication is available at http://journals.plos.org/plospathogensMycobacteria, such as the etiological
agent of human tuberculosis, Mycobacterium
tuberculosis, are protected by an impermeable
cell envelope composed of an inner
cytoplasmic membrane, a peptidoglycan
layer, an arabinogalactan layer, and an
outer membrane. This second membrane
consists of covalently linked, tightly packed
long-chain mycolic acids [1,2] and noncovalently
bound shorter lipids involved in
pathogenicity [3–5]. To ensure protein
transport across this complex cell envelope,
mycobacteria use various secretion pathways,
such as the SecA1-mediated general
secretory pathway [6,7], an alternative
SecA2-operated pathway [8], a twin-arginine
translocation system [9,10], and a
specialized secretion pathway variously
named ESAT-6-, SNM-, ESX-, or type
VII secretion [11–16]. The latter pathway,
hereafter referred to as type VII secretion
(T7S), has recently become a large and
competitive research topic that is closely
linked to studies of host–pathogen interactions
of M. tuberculosis [17] and other
pathogenic mycobacteria [16]. Molecular
details are just beginning to be revealed
[18–22] showing that T7S systems are
complex machineries with multiple components
and multiple substrates. Despite
their biological importance, there has been
a lack of a clear naming policy for the
components and substrates of these systems.
As there are multiple paralogous T7S
systems within the Mycobacteria and
orthologous systems in related bacteria,
we are concerned that, without a unified
nomenclature system, a multitude of redundant
and obscure gene names will be
used that will inevitably lead to confusion
and hinder future progress. In this opinion
piece we will therefore propose and introduce
a systematic nomenclature with
guidelines for name selection of new
components that will greatly facilitate
communication and understanding in this
rapidly developing field of research.http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1000507Publisher's versio
Performance of Basic Life Support by Lifeboat Crewmembers While Wearing a Survival Suit and Life Vest:A Randomized Controlled Trial
Introduction: Crewmembers of the “Royal Netherlands Sea Rescue Institution” (KNRM) lifeboats must wear heavy survival suits with integrated lifejackets. This and the challenging environment onboard (boat movements, limited space) might influence Basic Life Support (BLS) performance. The primary objective of this study was to assess the impact of the protective gear on single-rescuer BLS-quality. Material and Methods: Sixty-five active KNRM crewmembers who had recently undergone a BLS-refresher course were randomized to wear either their protective gear (n = 32) or their civilian clothes (n = 33; control group) and performed five 2-min sessions of single rescuer BLS on a mannequin on dry land. BLS-quality was assessed according to Dutch and European Resuscitation guidelines. A between group analysis (Mann-Whitney U) and a repeated within group analysis of both groups (Friedman test) were performed. Results: There were no major demographic differences between the groups. The protective gear did not significant impair BLS-quality. It was also not associated with a significant increase in the perceived exertion of BLS (Borg's Rating scale). Compression depth, compression frequency, the percentage of correct compression depth and of not leaning on the thorax, and ventilation volumes in both groups were suboptimal when evaluated according to the BLS-guidelines. Conclusions: The protective gear worn by KNRM lifeboat-crewmembers does not have a significant influence on BLS-quality under controlled study conditions. The impact and significance on outcome in real life situations needs to be studied further. This study provides valuable input for optimizing the BLS-skills of lifeboat crewmembers
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