Unsupervised Lesion Detection via Image Restoration with a Normative Prior

Unsupervised lesion detection is a challenging problem that requires accurately estimating normative distributions of healthy anatomy and detecting lesions as outliers without training examples. Recently, this problem has received increased attention from the research community following the advances in unsupervised learning with deep learning. Such advances allow the estimation of high-dimensional distributions, such as normative distributions, with higher accuracy than previous methods.The main approach of the recently proposed methods is to learn a latent-variable model parameterized with networks to approximate the normative distribution using example images showing healthy anatomy, perform prior-projection, i.e. reconstruct the image with lesions using the latent-variable model, and determine lesions based on the differences between the reconstructed and original images. While being promising, the prior-projection step often leads to a large number of false positives. In this work, we approach unsupervised lesion detection as an image restoration problem and propose a probabilistic model that uses a network-based prior as the normative distribution and detect lesions pixel-wise using MAP estimation. The probabilistic model punishes large deviations between restored and original images, reducing false positives in pixel-wise detections. Experiments with gliomas and stroke lesions in brain MRI using publicly available datasets show that the proposed approach outperforms the state-of-the-art unsupervised methods by a substantial margin, +0.13 (AUC), for both glioma and stroke detection. Extensive model analysis confirms the effectiveness of MAP-based image restoration.Comment: Extended version of 'Unsupervised Lesion Detection via Image Restoration with a Normative Prior' (MIDL2019

Interpretable Fully Convolutional Classification of Intrapapillary Capillary Loops for Real-Time Detection of Early Squamous Neoplasia

In this work, we have concentrated our efforts on the interpretability of classification results coming from a fully convolutional neural network. Motivated by the classification of oesophageal tissue for real-time detection of early squamous neoplasia, the most frequent kind of oesophageal cancer in Asia, we present a new dataset and a novel deep learning method that by means of deep supervision and a newly introduced concept, the embedded Class Activation Map (eCAM), focuses on the interpretability of results as a design constraint of a convolutional network. We present a new approach to visualise attention that aims to give some insights on those areas of the oesophageal tissue that lead a network to conclude that the images belong to a particular class and compare them with those visual features employed by clinicians to produce a clinical diagnosis. In comparison to a baseline method which does not feature deep supervision but provides attention by grafting Class Activation Maps, we improve the F1-score from 87.3% to 92.7% and provide more detailed attention maps

NFormer: Robust Person Re-identification with Neighbor Transformer

Person re-identification aims to retrieve persons in highly varying settings across different cameras and scenarios, in which robust and discriminative representation learning is crucial. Most research considers learning representations from single images, ignoring any potential interactions between them. However, due to the high intra-identity variations, ignoring such interactions typically leads to outlier features. To tackle this issue, we propose a Neighbor Transformer Network, or NFormer, which explicitly models interactions across all input images, thus suppressing outlier features and leading to more robust representations overall. As modelling interactions between enormous amount of images is a massive task with lots of distractors, NFormer introduces two novel modules, the Landmark Agent Attention, and the Reciprocal Neighbor Softmax. Specifically, the Landmark Agent Attention efficiently models the relation map between images by a low-rank factorization with a few landmarks in feature space. Moreover, the Reciprocal Neighbor Softmax achieves sparse attention to relevant -- rather than all -- neighbors only, which alleviates interference of irrelevant representations and further relieves the computational burden. In experiments on four large-scale datasets, NFormer achieves a new state-of-the-art. The code is released at \url{https://github.com/haochenheheda/NFormer}.Comment: 8 pages, 7 figures, CVPR2022 poste