4,585 research outputs found
Computational techniques to interpret the neural code underlying complex cognitive processes
Advances in large-scale neural recording technology have significantly improved the
capacity to further elucidate the neural code underlying complex cognitive processes.
This thesis aimed to investigate two research questions in rodent models. First, what
is the role of the hippocampus in memory and specifically what is the underlying
neural code that contributes to spatial memory and navigational decision-making.
Second, how is social cognition represented in the medial prefrontal cortex at the
level of individual neurons. To start, the thesis begins by investigating memory and
social cognition in the context of healthy and diseased states that use non-invasive
methods (i.e. fMRI and animal behavioural studies). The main body of the thesis
then shifts to developing our fundamental understanding of the neural mechanisms
underpinning these cognitive processes by applying computational techniques to ana lyse stable large-scale neural recordings. To achieve this, tailored calcium imaging
and behaviour preprocessing computational pipelines were developed and optimised
for use in social interaction and spatial navigation experimental analysis. In parallel,
a review was conducted on methods for multivariate/neural population analysis. A
comparison of multiple neural manifold learning (NML) algorithms identified that non linear algorithms such as UMAP are more adaptable across datasets of varying noise
and behavioural complexity. Furthermore, the review visualises how NML can be
applied to disease states in the brain and introduces the secondary analyses that
can be used to enhance or characterise a neural manifold. Lastly, the preprocessing
and analytical pipelines were combined to investigate the neural mechanisms in volved in social cognition and spatial memory. The social cognition study explored
how neural firing in the medial Prefrontal cortex changed as a function of the social
dominance paradigm, the "Tube Test". The univariate analysis identified an ensemble
of behavioural-tuned neurons that fire preferentially during specific behaviours such
as "pushing" or "retreating" for the animal’s own behaviour and/or the competitor’s
behaviour. Furthermore, in dominant animals, the neural population exhibited greater
average firing than that of subordinate animals. Next, to investigate spatial memory,
a spatial recency task was used, where rats learnt to navigate towards one of three
reward locations and then recall the rewarded location of the session. During the
task, over 1000 neurons were recorded from the hippocampal CA1 region for five rats
over multiple sessions. Multivariate analysis revealed that the sequence of neurons encoding an animal’s spatial position leading up to a rewarded location was also active
in the decision period before the animal navigates to the rewarded location. The result
posits that prospective replay of neural sequences in the hippocampal CA1 region
could provide a mechanism by which decision-making is supported
Analysing behavioural factors that impact financial stock returns. The case of COVID-19 pandemic in the financial markets.
This thesis represents a pivotal advancement in the realm of behavioural finance, seamlessly integrating both classical and state-of-the-art models. It navigates the performance and applicability of the Irrational Fractional Brownian Motion (IFBM) model, while also delving into the propagation of investor sentiment, emphasizing the indispensable role of hands-on experiences in understanding, applying, and refining complex financial models.
Financial markets, characterized by ’fat tails’ in price change distributions, often challenge traditional models such as the Geometric Brownian Motion (GBM). Addressing this, the research pivots towards the Irrational Fractional Brownian Motion Model (IFBM), a groundbreaking model initially proposed by (Dhesi and Ausloos, 2016) and further enriched in (Dhesi et al., 2019). This model, tailored to encapsulate the ’fat tail’ behaviour in asset returns, serves as the linchpin for the first chapter of this thesis.
Under the insightful guidance of Gurjeet Dhesi, a co-author of the IFBM model, we delved into its intricacies and practical applications. The first chapter aspires to evaluate the IFBM’s performance in real-world scenarios, enhancing its methodological robustness. To achieve this, a tailored algorithm was crafted for its rigorous testing, alongside the application of a modified Chi-square test for stability assessment. Furthermore, the deployment of Shannon’s entropy, from an information theory perspective, offers a nuanced understanding of the model. The S&P500 data is wielded as an empirical testing bed, reflecting real-world financial market dynamics. Upon confirming the model’s robustness, the IFBM is then applied to FTSE data during the tumultuous COVID-19 phase. This period, marked by extraordinary market oscillations, serves as an ideal backdrop to assess the IFBM’s capability in tracking extreme market shifts.
Transitioning to the second chapter, the focus shifts to the potentially influential realm of investor sentiment, seen as one of the many factors contributing to fat tails’ presence in return distributions. Building on insights from (Baker and Wurgler, 2007), we examine the potential impact of political speeches and daily briefings from 10 Downing Street during the COVID-19 crisis on market sentiment. Recognizing the profound market impact of such communications, the chapter seeks correlations between these briefings and market fluctuations.
Employing advanced Natural Language Processing (NLP) techniques, this chapter harnesses the power of the Bidirectional Encoder Representations from Transformers (BERT) algorithm (Devlin et al., 2018) to extract sentiment from governmental communications. By comparing the derived sentiment scores with stock market indices’ performance metrics, potential relationships between public communications and market trajectories are unveiled. This approach represents a melding of traditional finance theory with state-of-the-art machine learning techniques, offering a fresh lens through which the dynamics of market behaviour can be understood in the context of external communications.
In conclusion, this thesis provides an intricate examination of the IFBM model’s performance and the influence of investor sentiment, especially under crisis conditions. This exploration not only advances the discourse in behavioural finance but also underscores the pivotal role of sophisticated models in understanding and predicting market trajectories
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Pattern recognition in the nucleation kinetics of non-equilibrium self-assembly
Inspired by biology’s most sophisticated computer, the brain, neural networks constitute a profound reformulation of computational principles. Analogous high-dimensional, highly interconnected computational architectures also arise within information-processing molecular systems inside living cells, such as signal transduction cascades and genetic regulatory networks. Might collective modes analogous to neural computation be found more broadly in other physical and chemical processes, even those that ostensibly play non-information-processing roles? Here we examine nucleation during self-assembly of multicomponent structures, showing that high-dimensional patterns of concentrations can be discriminated and classified in a manner similar to neural network computation. Specifically, we design a set of 917 DNA tiles that can self-assemble in three alternative ways such that competitive nucleation depends sensitively on the extent of colocalization of high-concentration tiles within the three structures. The system was trained in silico to classify a set of 18 grayscale 30 × 30 pixel images into three categories. Experimentally, fluorescence and atomic force microscopy measurements during and after a 150 hour anneal established that all trained images were correctly classified, whereas a test set of image variations probed the robustness of the results. Although slow compared to previous biochemical neural networks, our approach is compact, robust and scalable. Our findings suggest that ubiquitous physical phenomena, such as nucleation, may hold powerful information-processing capabilities when they occur within high-dimensional multicomponent systems
Strategy Tripod Perspective on the Determinants of Airline Efficiency in A Global Context: An Application of DEA and Tobit Analysis
The airline industry is vital to contemporary civilization since it is a key player in the globalization process: linking regions, fostering global commerce, promoting tourism and aiding economic and social progress. However, there has been little study on the link between the operational environment and airline efficiency. Investigating the amalgamation of institutions, organisations and strategic decisions is critical to understanding how airlines operate efficiently.
This research aims to employ the strategy tripod perspective to investigate the efficiency of a global airline sample using a non-parametric linear programming method (data envelopment analysis [DEA]). Using a Tobit regression, the bootstrapped DEA efficiency change scores are further regressed to determine the drivers of efficiency. The strategy tripod is employed to assess the impact of institutions, industry and resources on airline efficiency. Institutions are measured by global indices of destination attractiveness; industry, including competition, jet fuel and business model; and finally, resources, such as the number of full-time employees, alliances, ownership and connectivity. The first part of the study uses panel data from 35 major airlines, collected from their annual reports for the period 2011 to 2018, and country attractiveness indices from global indicators. The second part of the research involves a qualitative data collection approach and semi-structured interviews with experts in the field to evaluate the impact of COVID-19 on the first part’s significant findings.
The main findings reveal that airlines operate at a highly competitive level regardless of their competition intensity or origin. Furthermore, the unpredictability of the environment complicates airline operations. The efficiency drivers of an airline are partially determined by its type of business model, its degree of cooperation and how fuel cost is managed. Trade openness has a negative influence on airline efficiency. COVID-19 has toppled the airline industry, forcing airlines to reconsider their business model and continuously increase cooperation. Human resources, sustainability and alternative fuel sources are critical to airline survival. Finally, this study provides some evidence for the practicality of the strategy tripod and hints at the need for a broader approach in the study of international strategies
Multidisciplinary perspectives on Artificial Intelligence and the law
This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio
Air Quality Research Using Remote Sensing
Air pollution is a worldwide environmental hazard that poses serious consequences not only for human health and the climate but also for agriculture, ecosystems, and cultural heritage, among other factors. According to the WHO, there are 8 million premature deaths every year as a result of exposure to ambient air pollution. In addition, more than 90% of the world’s population live in areas where the air quality is poor, exceeding the recommended limits. On the other hand, air pollution and the climate co-influence one another through complex physicochemical interactions in the atmosphere that alter the Earth’s energy balance and have implications for climate change and the air quality. It is important to measure specific atmospheric parameters and pollutant compound concentrations, monitor their variations, and analyze different scenarios with the aim of assessing the air pollution levels and developing early warning and forecast systems as a means of improving the air quality and safeguarding public health. Such measures can also form part of efforts to achieve a reduction in the number of air pollution casualties and mitigate climate change phenomena. This book contains contributions focusing on remote sensing techniques for evaluating air quality, including the use of in situ data, modeling approaches, and the synthesis of different instrumentations and techniques. The papers published in this book highlight the importance and relevance of air quality studies and the potential of remote sensing, particularly that conducted from Earth observation platforms, to shed light on this topic
LIPIcs, Volume 251, ITCS 2023, Complete Volume
LIPIcs, Volume 251, ITCS 2023, Complete Volum
Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea
ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK
Contactless excitation for electric machines: high temperature superconducting flux pumps
With the intensification of global warming and climate change, the pace of transformation to a neutral-emission society is accelerating. In various sectors, electrification has become the absolute tendency to promote such a movement, where electric machines play an important role in the current power generation system. It is widely convinced that electric machines with very high power density are essential for future applications, which, however, can be hardly achieved by conventional technologies. Owing to the maturation of the second generation (2G) high temperature superconducting (HTS) technologies, it has been recognized that superconducting machine could be a competitive candidate to realize the vision.
One significant obstacle that hinders the implementation of superconducting machines is how to provide the required magnetic fields, or in other words, how to energise them appropriately. Conventional direct injection is not suitable for HTS machines, because the current leads would bridge ambident temperature to the cryogenic environment, which can impose considerable heat load on the system and increase the operational cost. Thus, an efficient energisation method is demanded by HTS machines. As an emerging technology that can accumulate substantial flux in a closed loop without any physical contact, HTS flux pumps have been proposed as a promising solution.
Among the existing developed HTS flux pumps, rotary HTS flux pumps, or so-called HTS dynamo, can output non-zero time-averaged DC voltage and charge the rest of the circuit if a closed loop has been formed. This type of flux pump is often employed together with HTS coils, where the HTS coils can potentially work in the persistent current mode, and act like electromagnets with a considerable magnetic field, having a wide range of applications in industry. The output characteristics of rotary HTS flux pumps have been extensively explored through experiments and finite element method (FEM) simulations, yet the work on constructing statistical models as an alternative approach to capture key characteristics has not been studied. In this thesis, a 2D FEM program has been developed to model the operation of rotary HTS flux pumps and evaluate the effects of different factors on the output voltage through parameter sweeping and analysis of variance. Typical design considerations,
including the operating frequency, air gap, HTS tape width, and remanent flux density have been investigated, in particular, the bilateral effect of HTS tape width has been discovered and explained by looking at the averaged integration of the electric field over the HTS tape. Based on the data obtained from various simulations, regression analysis has been conducted through a collection of machine learning methods. It has been demonstrated that the output voltage of a rotary HTS flux pump can be obtained promptly with satisfactory accuracy via Gaussian process regression, aiming to provide a novel approach for future research and a powerful design tool for industrial applications using rotary HTS flux pumps.
To enhance the applicability of the proposed statistical models, an updated FEM program has been built to take more parameters into account. The newly added parameters, namely the rotor radius and the width of permanent magnet, together with formerly included ones, should have covered all the key design parameters for a rotary HTS flux pump. Based on data collected from the FEM model, a well-trained semi-deep neural network (DNN) model with a back-propagation algorithm has been put forward and validated. The proposed DNN model is capable of quantifying the output voltage of a rotary HTS flux pump instantly with an overall accuracy of 98% with respect to the simulated values with all design parameters explicitly specified. The model possesses a powerful ability to characterize the output behaviour of rotary HTS flux pumps by integrating all design parameters, and the output characteristics of rotary HTS flux pumps have been successfully demonstrated and visualized using this model. Compared to conventional time-consuming FEM-based numerical models, the proposed DNN model has the advantages of fast learning, accurate computation, as well as strong programmability. Therefore, the DNN model can greatly facilitate the design and optimization process for rotary HTS flux pumps. An executable application has been developed accordingly based on the DNN model, which is believed to provide a useful tool for learners and designers of rotary HTS flux pumps.
A new variant inspired by the working principles of rotary HTS flux pumps has been proposed and termed as stationary wave HTS flux pumps. The superiority of this type is that it has a simple structure without any moving components, and it utilises a controllable current-driven electromagnet to provide the required magnetic field. It has been demonstrated that the origin of the output voltage is determined by the asymmetric distribution of the dynamic resistance in the HTS tape, for which the electromagnet must be placed at such a position that its central line is not aligned with that of the HTS tape. A numerical model has
been built to simulate the operation of a stationary wave HTS flux pump, based on which the output characteristics and dynamic resistance against various parameters have been investigated. Besides, accurate and reliable statistical models have been proposed to predict the open circuit voltage and effective dynamic resistance by adapting the previously developed machine learning techniques.
The work presented in this PhD thesis can bring more insight into HTS flux pumps as an emerging promising contactless energisation technology, and the proposed statistical models can be particularly useful for the design and optimization of such devices
AI-based design methodologies for hot form quench (HFQ®)
This thesis aims to develop advanced design methodologies that fully exploit the capabilities of the Hot Form Quench (HFQ®) stamping process in stamping complex geometric features in high-strength aluminium alloy structural components. While previous research has focused on material models for FE simulations, these simulations are not suitable for early-phase design due to their high computational cost and expertise requirements. This project has two main objectives: first, to develop design guidelines for the early-stage design phase; and second, to create a machine learning-based platform that can optimise 3D geometries under hot stamping constraints, for both early and late-stage design. With these methodologies, the aim is to facilitate the incorporation of HFQ capabilities into component geometry design, enabling the full realisation of its benefits.
To achieve the objectives of this project, two main efforts were undertaken. Firstly, the analysis of aluminium alloys for stamping deep corners was simplified by identifying the effects of corner geometry and material characteristics on post-form thinning distribution. New equation sets were proposed to model trends and design maps were created to guide component design at early stages. Secondly, a platform was developed to optimise 3D geometries for stamping, using deep learning technologies to incorporate manufacturing capabilities. This platform combined two neural networks: a geometry generator based on Signed Distance Functions (SDFs), and an image-based manufacturability surrogate model. The platform used gradient-based techniques to update the inputs to the geometry generator based on the surrogate model's manufacturability information. The effectiveness of the platform was demonstrated on two geometry classes, Corners and Bulkheads, with five case studies conducted to optimise under post-stamped thinning constraints. Results showed that the platform allowed for free morphing of complex geometries, leading to significant improvements in component quality.
The research outcomes represent a significant contribution to the field of technologically advanced manufacturing methods and offer promising avenues for future research. The developed methodologies provide practical solutions for designers to identify optimal component geometries, ensuring manufacturing feasibility and reducing design development time and costs. The potential applications of these methodologies extend to real-world industrial settings and can significantly contribute to the continued advancement of the manufacturing sector.Open Acces
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