Impulse for animal welfare outside the experiment

Animal welfare is a growing societal concern and the well-being of animals used for experimental purposes is under particular scrutiny. The vast majority of laboratory animals are mice living in small cages that do not offer very much variety. Moreover, the experimental procedure often takes very little time compared to the time these animals have been bred to the desired age or are being held available for animal experimentation. However, for the assessment of animal welfare, the time spent waiting for an experiment or the time spent after finishing an experiment has also to be taken into account. In addition to experimental animals, many additional animals (e.g. for breeding and maintenance of genetic lines, surplus animals) are related to animal experimentation and usually face similar living conditions. Therefore, in terms of improving the overall welfare of laboratory animals, there is not only a need for refinement of experimental conditions but especially for improving living conditions outside the experiment. The improvement of animal welfare thus depends to a large extent on the housing and maintenance conditions of all animals related to experimentation. Given the current state of animal welfare research there is indeed a great potential for improving the overall welfare of laboratory animals

Extrapolating from Laboratory Behavioral Research on Nonhuman Primates Is Unjustified

Conducting research on animals is supposed to be valuable because it provides information on how human mechanisms work. But for the use of animal models to be ethically justified, it must be epistemically justified. The inference from an observation about an animal model to a conclusion about humans must be warranted for the use of animals to be moral. When researchers infer from animals to humans, it’s an extrapolation. Often non-human primates are used as animal models in laboratory behavioral research. The target populations are humans and other non-human primates. I argue that the epistemology of extrapolation renders the use of non-human primates in laboratory behavioral research unreliable. If the model is relevantly similar to the target, then the experimental conditions introduce confounding variables. If the model is not relevantly similar to the target, then the observations of the model cannot be extrapolated to the target. Since using non-human primates in as animal models in laboratory behavioral research is not epistemically justified, using them as animal models in laboratory behavioral research is not ethically justified

Animal poisonings in Belgium: a review of the past decade

This review focuses on poisonings in companion animals, including horses, farm animals and wildlife, investigated and recorded during the past ten years at the Laboratory of Toxicology of the Faculty of Veterinary Medicine (Ghent University) and the National Poison Centre in Belgium. The causative agents of poisoning incidents vary among the different species. The Laboratory of Toxicology of the Faculty of Veterinary Medicine reports that the majority of poisoning incidents in companion animals, and especially in dogs and cats, are due to contact with insecticides and pesticides, whereas horses are more frequently poisoned by plant toxins. Farm animals, on the other hand, are mainly intoxicated by heavy metals, toxic plants and agrochemicals. The Belgian Poison Centre reports that intoxications in companion animals are mostly with agrochemicals, household products and drugs, whereas in farm animals intoxications with agrochemicals are a common problem. This review gives an overview of the most common causes of intoxication and their association with the different animal species. In addition, some rare or difficult to diagnose intoxications are described, which account for a small number of poisoning cases

Recent updates on incubation of drug craving: a mini-review

Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving

The development of laboratory animal science and animal care of legislation and the consummation

Laboratory animal science is the use of non-human animals in experiments to obtain new knowledge and new technologies in biomedical research and testing. In order to develop science and technology, the human carried out a large number of animal experiments, these experiments greatly expanded the vision of related research field, and make a great contribution to human beings. Meanwhile, animal experiments also bring us a certain extent of negative effects. Countries around the world have adopted legislative measures to regulate behavior of animal experiments, but in the process of legislation and enforcement are not wholly satisfactory. On the basis of present situation of laboratory animal science and existing problems, with the comparison of animal welfare act between Europe and China, the author puts forward the ideas of perfecting experimental animals’ laws and its enforcement proposals

Miniature bioelectric device accurately measures and telemeters temperature

Miniature micropower solid-state circuit measures and telemeters the body temperature of laboratory animals over periods up to two years. The circuit employs a thermistor as a temperature sensing element and an fm transmitter. It is constructed from conventional discrete components or integrated circuits

Culture Techniques for Rearing Soil Anthropods

Excerpt: Interest in soil biology has been prompted by recent investigations into the action of insecticides on plants and animals. Observations in the field must be supplemented by laboratory investigations conducted under controlled conditions. Consequently, it becomes necessary to rear and handle soil animals under artificial situations for bio-assay and life cycle studies. When large numbers of individuals are required, special problems in maintenance and manipulation arise. Relatively inexpensive and simple methods for such projects are essential and this paper describes some of those techniques which we have found expedient

Growth hormone secretion during space flight and evaluation of the physiological responses of animals held in the research animal holding facility

The spaceflight of the Research Animal Holding Facility (RAHF) on the Space Laboratory 3 (SL 3) provided the opportunity to evaluate the suitability of the RAHF for housing and maintaining experimental animals during spaceflight, and to determine changes in the secretion of growth hormone during spaceflight. Using ground-based studies the following were investigated: the optimum conditions for creating gravitational force on space flight animals; neural pathways that may play a role in the space flight syndrome; and the time course of muscle atrophy due to hypodynamia and hypokenesia in hindlimb-suspended animals and the role of growth hormone in these processes