Assessing the effectiveness of a longitudinal knowledge dissemination intervention: Sharing research findings in rural South Africa

Knowledge dissemination interventions (KDIs) are integral to knowledge brokerage activities in research as part of the ethics of practice, but are seldom evaluated. In this case study, we critically reflect on an annual KDI as part of knowledge brokerage activities in the MRC/Wits-Agincourt Unit health and demographic surveillance system (HDSS) in rural South Africa from 2001 to 2015. The HDSS findings on births, deaths and migrations, as well as nested research project results, were shared with villagers, village leaders and service providers. The data used for this case study comprised secondary analysis of 13 reports and 762 evaluation forms of annual village-based meetings; records of requests for data from stakeholders; and qualitative analysis of 15 individual and five focus group interviews with local leaders and service providers involving 60 people. Over time, the KDI evolved from taking place over one week a year to being extended over six months, and to include briefings with service providers and local leaders. Attendance at village-level meetings remained low at an average of 3 per cent of the total adult population. Since 2011, the KDI village-based meetings have developed into an embedded community forum for discussion of topical village issues. There has been a decrease in requests for health-care and other services from the research unit, with a concurrent increase in research-related questions and requests for data from service providers, village leaders and political representatives. We conclude that, in this setting, the dissemination of research findings is not a linear exchange of information from the researchers to village residents and their leadership, but is increasingly multi-directional. KDIs are a key component of knowledge brokerage activities and involve, influence and are influenced by other aspects of knowledge brokerage, such as identifying, engaging and connecting with stakeholders and supporting sustainability

The high scope approach to early learning

Learning Objectives: After studying this chapter the reader should be able to: • Describe the historical origins, the longitudinal research, and the theoretical underpinnings of the HighScope approach. • Identify the teaching strategies adopted by HighScope educators. • Appreciate the curriculum content. • Understand the HighScope approach to the assessment of children’s learning. • Consider some criticisms of the HighScope research and approach to early learning. This chapter aims to provide an overview of the HighScope curriculum. It is presented in order of the learning objectives listed above

Interferometric distillation and determination of unknown two-qubit entanglement

We propose a scheme for both distilling and quantifying entanglement, applicable to individual copies of an arbitrary unknown two-qubit state. It is realized in a usual two-qubit interferometry with local filtering. Proper filtering operation for the maximal distillation of the state is achieved, by erasing single-qubit interference, and then the concurrence of the state is determined directly from the visibilities of two-qubit interference. We compare the scheme with full state tomography

Keratin Dynamics: Modeling the Interplay between Turnover and Transport

Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses for the turnover and transport of the keratin material in epithelial cells are tested. The interplay between turnover and transport and their effects on the keratin organization in cells are hence investigated by combining mathematical modeling and experimental data. Amongst the collection of mathematical models considered, a best model strongly supported by experimental data is identified. Fundamental to this approach is the fact that optimal parameter values associated with the best fit for each model are established. The best candidate among the best fits is characterized by the disassembly of the assembled keratin material in the perinuclear region and an active transport of the assembled keratin. Our study shows that an active transport of the assembled keratin is required to explain the experimentally observed keratin organization.Comment: 27 pages, 11 Figure

Ultrabroadband dispersive radiation by spatiotemporal oscillation of multimode waves

Despite the abundance and importance of three-dimensional systems, relatively little progress has been made on spatiotemporal nonlinear optical waves compared to time-only or space-only systems. Here we study radiation emitted by three-dimensionally evolving nonlinear optical waves in multimode fiber. Spatiotemporal oscillations of solitons in the fiber generate multimode dispersive wave sidebands over an ultrabroadband spectral range. This work suggests routes to multipurpose sources of coherent electromagnetic waves, with unprecedented wavelength coverage.Comment: 13 pages, 3 figures, Supplementary Movie files for preprint available at: https://www.youtube.com/watch?v=h3meO8G6ZzA and https://www.youtube.com/watch?v=k42llO-c1r

START: Smoothed particle hydrodynamics with tree-based accelerated radiative transfer

We present a novel radiation hydrodynamics code, START, which is a smoothed particle hydrodynamics (SPH) scheme coupled with accelerated radiative transfer. The basic idea for the acceleration of radiative transfer is parallel to the tree algorithm that is hitherto used to speed up the gravitational force calculation in an N-body system. It is demonstrated that the radiative transfer calculations can be dramatically accelerated, where the computational time is scaled as Np log Ns for Np SPH particles and Ns radiation sources. Such acceleration allows us to readily include not only numerous sources but also scattering photons, even if the total number of radiation sources is comparable to that of SPH particles. Here, a test simulation is presented for a multiple source problem, where the results with START are compared to those with a radiation SPH code without tree-based acceleration. We find that the results agree well with each other if we set the tolerance parameter as < 1.0, and then it demonstrates that START can solve radiative transfer faster without reducing the accuracy. One of important applications with START is to solve the transfer of diffuse ionizing photons, where each SPH particle is regarded as an emitter. To illustrate the competence of START, we simulate the shadowing effect by dense clumps around an ionizing source. As a result, it is found that the erosion of shadows by diffuse recombination photons can be solved. Such an effect is of great significance to reveal the cosmic reionization process.Comment: 14 pages, 23 figures, accepted for publication in MNRA

Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1

Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer. The role of transcription factor Vezf1 in vascular development and regulation of angiogenesis has been defined by several earlier studies. Through construction of a computational model for Vezf1, work here has identified a novel small molecule drug capable of inhibiting Vezf1 from binding to its cognate DNA binding site. Using structure-based design and virtual screening of the NCI Diversity Compound Library, 12 shortlisted compounds were tested for their ability to interfere with the binding of Vezf1 to DNA using electrophoretic gel mobility shift assays. We identified one compound, T4, which has an IC50 of 20 &mu;M. Using murine endothelial cells, MSS31, we tested the effect of T4 on endothelial cell viability and angiogenesis by using tube formation assay. Our data show that addition of T4 in cell culture medium does not affect cell viability at concentrations lower or equal to its IC 50 but strongly inhibits the network formation by MSS31 in the tube formation assays. Given its potential efficacy, this inhibitor has significant therapeutic potential in several human diseases

A software and hardware evaluation of revolutionary turbo MIMO OFDM schemes for 5 GHz WLANs

Globally, WLANs operating in the 5 GHz band have been standardized by the IEEE (North America), ETSI (Europe) and ARID (Japan). A harmonized physical layer is specified offering up to 54 Mbits/s using rate adaptive coded orthogonal frequency division multiplexing (COFDM). Multiple input multiple output (MIMO) antenna architectures coupled with soft input soft output (SISO) iterative decoding algorithms represent a revolutionary approach to the design of WLANs. At present, these techniques are the subject of intense theoretic research. In this contribution, the performance of a newly proposed iterative MIMO-OEDM architecture is explored using MIMO channel data captured in the 5 GHz band. Theoretically, this technology has the potential to significantly increase future WLAN data rates. However, little practical evaluation has been reported in the literature. To address this situation, this paper describes the construction of a broadband 5 GHz MIMO-OFDM test-bed. This advanced baseband/RF platform will be used in the future to evaluate emerging MIMO-OFDM WLAN architecture