Question answering systems for health professionals at the point of care -- a systematic review

Objective: Question answering (QA) systems have the potential to improve the quality of clinical care by providing health professionals with the latest and most relevant evidence. However, QA systems have not been widely adopted. This systematic review aims to characterize current medical QA systems, assess their suitability for healthcare, and identify areas of improvement. Materials and methods: We searched PubMed, IEEE Xplore, ACM Digital Library, ACL Anthology and forward and backward citations on 7th February 2023. We included peer-reviewed journal and conference papers describing the design and evaluation of biomedical QA systems. Two reviewers screened titles, abstracts, and full-text articles. We conducted a narrative synthesis and risk of bias assessment for each study. We assessed the utility of biomedical QA systems. Results: We included 79 studies and identified themes, including question realism, answer reliability, answer utility, clinical specialism, systems, usability, and evaluation methods. Clinicians' questions used to train and evaluate QA systems were restricted to certain sources, types and complexity levels. No system communicated confidence levels in the answers or sources. Many studies suffered from high risks of bias and applicability concerns. Only 8 studies completely satisfied any criterion for clinical utility, and only 7 reported user evaluations. Most systems were built with limited input from clinicians. Discussion: While machine learning methods have led to increased accuracy, most studies imperfectly reflected real-world healthcare information needs. Key research priorities include developing more realistic healthcare QA datasets and considering the reliability of answer sources, rather than merely focusing on accuracy.Comment: Accepted to the Journal of the American Medical Informatics Association (JAMIA

Large-Scale Knowledge Synthesis and Complex Information Retrieval from Biomedical Documents

Recent advances in the healthcare industry have led to an abundance of unstructured data, making it challenging to perform tasks such as efficient and accurate information retrieval at scale. Our work offers an all-in-one scalable solution for extracting and exploring complex information from large-scale research documents, which would otherwise be tedious. First, we briefly explain our knowledge synthesis process to extract helpful information from unstructured text data of research documents. Then, on top of the knowledge extracted from the documents, we perform complex information retrieval using three major components- Paragraph Retrieval, Triplet Retrieval from Knowledge Graphs, and Complex Question Answering (QA). These components combine lexical and semantic-based methods to retrieve paragraphs and triplets and perform faceted refinement for filtering these search results. The complexity of biomedical queries and documents necessitates using a QA system capable of handling queries more complex than factoid queries, which we evaluate qualitatively on the COVID-19 Open Research Dataset (CORD-19) to demonstrate the effectiveness and value-add

A Survey on Conversational Search and Applications in Biomedicine

This paper aims to provide a radical rundown on Conversation Search (ConvSearch), an approach to enhance the information retrieval method where users engage in a dialogue for the information-seeking tasks. In this survey, we predominantly focused on the human interactive characteristics of the ConvSearch systems, highlighting the operations of the action modules, likely the Retrieval system, Question-Answering, and Recommender system. We labeled various ConvSearch research problems in knowledge bases, natural language processing, and dialogue management systems along with the action modules. We further categorized the framework to ConvSearch and the application is directed toward biomedical and healthcare fields for the utilization of clinical social technology. Finally, we conclude by talking through the challenges and issues of ConvSearch, particularly in Bio-Medicine. Our main aim is to provide an integrated and unified vision of the ConvSearch components from different fields, which benefit the information-seeking process in healthcare systems

Overview of BioASQ 2023: The eleventh BioASQ challenge on Large-Scale Biomedical Semantic Indexing and Question Answering

This is an overview of the eleventh edition of the BioASQ challenge in the context of the Conference and Labs of the Evaluation Forum (CLEF) 2023. BioASQ is a series of international challenges promoting advances in large-scale biomedical semantic indexing and question answering. This year, BioASQ consisted of new editions of the two established tasks b and Synergy, and a new task (MedProcNER) on semantic annotation of clinical content in Spanish with medical procedures, which have a critical role in medical practice. In this edition of BioASQ, 28 competing teams submitted the results of more than 150 distinct systems in total for the three different shared tasks of the challenge. Similarly to previous editions, most of the participating systems achieved competitive performance, suggesting the continuous advancement of the state-of-the-art in the field.Comment: 24 pages, 12 tables, 3 figures. CLEF2023. arXiv admin note: text overlap with arXiv:2210.0685

Discriminative Marginalized Probabilistic Neural Method for Multi-Document Summarization of Medical Literature

Although current state-of-the-art Transformer-based solutions succeeded in a wide range for single-document NLP tasks, they still struggle to address multi-input tasks such as multi-document summarization. Many solutions truncate the inputs, thus ignoring potential summary-relevant contents, which is unacceptable in the medical domain where each information can be vital. Others leverage linear model approximations to apply multi-input concatenation, worsening the results because all information is considered, even if it is conflicting or noisy with respect to a shared background. Despite the importance and social impact of medicine, there are no ad-hoc solutions for multi-document summarization. For this reason, we propose a novel discriminative marginalized probabilistic method (DAMEN) trained to discriminate critical information from a cluster of topic-related medical documents and generate a multi-document summary via token probability marginalization. Results prove we outperform the previous state-of-the-art on a biomedical dataset for multi-document summarization of systematic literature reviews. Moreover, we perform extensive ablation studies to motivate the design choices and prove the importance of each module of our method