Isogeometric analysis for fluid shear stress in cancer cells

Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2018 do Instituto Politécnico de Lisboa. Código de referência IPL/2018/IGACFC_ISELThe microenvironment of the tumor is a key factor regulating tumor cell invasion and metastasis. The effects of physical factors in tumorigenesis is unclear. Shear stress, induced by liquid flow, plays a key role in proliferation, apoptosis, invasion, and metastasis of tumor cells. The mathematical models have the potential to elucidate the metastatic behavior of the cells’ membrane exposed to these microenvironment forces. Due to the shape configuration of the cancer cells, Non-uniform Rational B-splines (NURBS) lines are very adequate to define its geometric model. The Isogeometric Analysis allows a simplified transition of exact CAD models into the analysis avoiding the geometrical discontinuities of the traditional Galerkin traditional techniques. In this work, we use an isogeometric analysis to model the fluid-generated forces that tumor cells are exposed to in the vascular and tumor microenvironments, in the metastatic process. Using information provided by experimental tests in vitro, we present a suite of numerical experiments which indicate, for standard configurations, the metastatic behavior of cells exposed to such forces. The focus of this paper is strictly on geometrical sensitivities to the shear stress’ exhibition for the cell membrane, this being its innovation.info:eu-repo/semantics/publishedVersio

Isogeometric Analysis of the Navier-Stokes-Cahn-Hilliard equations with application to incompressible two-phase flows

In this work, we present our numerical results of the application of Galerkin-based Isogeometric Analysis (IGA) to incompressible Navier-Stokes-Cahn-Hilliard (NSCH) equations in velocity-pressure-phase field-chemical potential formulation. For the approximation of the velocity and pressure fields, LBB compatible non-uniform rational B-spline spaces are used which can be regarded as smooth generalizations of Taylor-Hood pairs of finite element spaces. The one-step \theta-scheme is used for the discretization in time. The static and rising bubble, in addition to the nonlinear Rayleigh-Taylor instability flow problems, are considered in two dimensions as model problems in order to investigate the numerical properties of the scheme