DREAM²S: Deformable Regions Driven by an Eulerian Accurate Minimization Method for Image and Video Segmentation

This paper deals with image and video segmentation using active contours. We propose a general form for the energy functional related to region-based active contours. We compute the associated evolution equation using shape derivation tools and accounting for the evolving region-based terms. Then we apply this general framework to compute the evolution equation from functionals that include various statistical measures of homogeneity for the region to be segmented. Experimental results show that the determinant of the covariance matrix appears to be a very relevant tool for segmentation of homogeneous color regions. As an example, it has been successfully applied to face segmentation in real video sequences

Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma

textOptical Coherence Tomography (OCT) is an optical tomography technique which provides high resolution non-invasive three-dimensional (3D) structural images of the sample based on coherent properties of light. The dissertation focuses on the use of OCT systems for detecting glaucoma, which is the second leading cause of blindness worldwide. First, as a prerequisite of analyzing ophthalmologic OCT images, a retinal sublayer segmentation algorithm is presented and implemented with GPU assisted computation. Then, a polarization-sensitive optical coherence tomography (PS-OCT) system was constructed for the study of glaucoma. Three closely related clinical and animal studies on early-stage glaucoma detection using either OCT or PS-OCT were performed. Statistical analysis of the study results indicates that the scattering property of retinal nerve fiber layer (RNFL) is the earliest indicator for glaucoma. Finally, to investigate the scattering properties of RNFL, a pathlength-multiplexed scattering-angle-diverse optical coherence tomography (PM-SAD-OCT) system was designed and built. PM-SAD-OCT images were collected from human and rodent retina as well as earthworm nerve cord. PM-SAD-OCT system shows promising potentials to detect neurodegenerative diseases including glaucoma.Biomedical Engineerin