210 research outputs found

    Master index to volumes 251-260

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    Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications

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    In several cases, current therapies available to treat a large number of musculoskeletal system diseases are unsatisfactory as they provide only temporary or partial restoration of the damaged or degenerated site. In an attempt to maintain a high standard of life quality and minimise the economic losses due to the treatments of these frequently occurring ailments and subsequent lost working days, alternative therapies are being explored. Contrary to the current treatments, tissue engineering aims to regenerate the impaired tissue rather than repair and alleviate the symptoms; thus offering a definitive solution. The annulus fibrosus (AF) of the intervertebral disc (IVD) is a musculoskeletal system component frequently subjected to degeneration and rupture, characterised by predominance of anisotropically arranged collagen fibres. In the present thesis, electrospinning technology is used to fabricate polycaprolactone (PCL) scaffolds intended to replicate the anisotropic structure of the AF. [Continues.

    Epidemiological, pathological and microbiological study of equine dental caries

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    Dental caries is caused by acidogenic oral micro-organisms which convert fermentable carbohydrates to acids that damage the tooth by causing a demineralisation and disintegration of the inorganic and organic substances of the tooth, respectively (Soames and Southam, 2005). In horses, two variants of dental caries occur: equine dental peripheral caries (PC) involving the periphery of teeth; and infundibular caries (IC) of the maxillary cheek teeth. Twenty-five veterinarians and equine dental technicians experienced in equine dentistry were recruited to perform a UK-wide survey and examined 706 horses for the presence PC and IC, as well as for concurrent dental disorders. The recorded survey results for individual horses included data on potential risk factors including breed, sex, age, diet and the postcode of stables. The prevalence of PC and IC in this population, was 51.7% and 45.5%, respectively. The most commonly and severely PC affected teeth were the three caudal cheek teeth (Triadan 09-11) and for IC were the Triadan 09s. In a multivariable model without observer as a random effect, potential risk factors for the development of PC were: the presence of IC, the presence of diastema/periodontal disease (PD), the presence of multiple concurrent dental disorders other than IC, being fed 2.1-3.0 kg concentrates per day, and living in South East England and South West England. The risk factors which remained significantly associated with the presence of PC in a multivariable model with observer as a random effect, were: feeding 2.1-3 kg concentrates per day, multiple concurrent dental disorders other than IC, the presence of diastema/periodontal disease; additionally, dental fractures now became significantly associated with the presence of PC. In a multivariable model without observer as a random effect, potential risk factors for the development of IC were: the presence of PC, the presence of multiple dental disorders other than IC, and increasing age. Horses in North England and South West England were significantly less likely to have IC than horses in other regions of England and Scotland. In a multivariable model with observer as random effect, the only remaining risk factors were increasing age and geographical region, with a significantly lower likelihood for horses to have IC in South West England than in the other regions. A molecular microbiological study on equine dental caries using a linear discriminant analysis effect size (LEfSe) at genus or higher level, showed Gemella and Actinobacillus to be the genera most associated with the PC study control group (no PC), and Streptococcus, Olsenella and Scardovia to be the genera most associated with PC. Additionally if LEfSe was performed at genus level only, then an additional genus shown to be associated with PC was Mitsuokella. The genus most associated with IC using LEfSe at genus or higher level was Acidaminococcus, while Bacillus was the genus most associated with the IC study control group (no IC). A pathological study examined PC-affected cheek teeth grossly, histologically and, by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Dental plaque, containing bacteria was found to cover the PC lesions. In peripheral cementum, PC lesions were categorised by their shape on histological cross sections of affected teeth into: flake-type, flask-like, or ellipsoid-shaped lesions or combinations of these patterns. Bacteria from surface lesions penetrated between Sharpey’s fibers of cementum in a direction perpendicular to the peripheral aspect of the tooth, destroying the intrinsic fibres and Sharpey’s fibers. Bacteria also penetrated in a direction parallel to the peripheral aspect of the tooth, undermining the intrinsic fibres, including at the level of incremental growth lines. Bacteria were also found in ellipsoid-shaped lesions and in cemental lacunae of affected cementum. In dentine affected by PC, bacteria were found within and between damaged dentinal tubules, sometimes causing flake-type lesions similar to those seen in cementum. Bacteria penetrated primary dentine and/or (regular/irregular) secondary dentine from the occlusal surface, or entered primary dentine through cementum and enamel from the peripheral aspect. Dental plaque containing bacteria were sometimes observed in dentinal fissure fractures. PC of enamel was only visible using SEM, because this was the only method which did not require prior decalcification, that almost completely removed enamel. In conclusion, PC and IC are prevalent dental disorders in the examined British equine population. The association between PC and concurrent dental disorders (multiple concurrent dental disorders, diastemata/periodontal disease and dental fractures), indicates that these should be addressed in affected horses. In horses affected by IC, the focus should be on treatment of IC itself (like infundibular fillings), because associations of IC were found with risk factors which cannot (or not easily) be controlled such as age and region. Several bacteria could be identified which were associated with PC and other bacteria were more associated with IC or control groups. It was confirmed in the pathological study that bacteria penetrate the cheek teeth affected by PC and IC. So the focus of treatment of PC and IC can also be on reducing the bacteria associated with PC and IC respectively, or the focus could be on prevention by making the teeth more resistant against caries by fluoride treatment. A critical assessment of the use of chlorhexidine mouthwashes and supplementation of fluoride are needed to evaluate its potential effects on PC and IC

    Products and Services

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    Today’s global economy offers more opportunities, but is also more complex and competitive than ever before. This fact leads to a wide range of research activity in different fields of interest, especially in the so-called high-tech sectors. This book is a result of widespread research and development activity from many researchers worldwide, covering the aspects of development activities in general, as well as various aspects of the practical application of knowledge

    Interval orders without odd crowns are defect optimal

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    SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

    Interval orders without odd crowns are defect optimal

    No full text

    Interval orders without odd crowns are defect optimal

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    SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

    Ceramic Materials

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    This is the first book of a series of forthcoming publications on this field by this publisher. The reader can enjoy both a classical printed version on demand for a small charge, as well as the online version free for download. Your citation decides about the acceptance, distribution, and impact of this piece of knowledge. Please enjoy reading and may this book help promote the progress in ceramic development for better life on earth

    Superconductors at the Nanoscale

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    By covering theory, design, and fabrication of nanostructured superconducting materials, this monograph is an invaluable resource for research and development. Examples are energy saving solutions, healthcare, and communication technologies. Key ingredients are nanopatterned materials which help to improve the superconducting critical parameters and performance of superconducting devices, and lead to novel functionalities. Contents Tutorial on nanostructured superconductors Imaging vortices in superconductors: from the atomic scale to macroscopic distances Probing vortex dynamics on a single vortex level by scanning ac-susceptibility microscopy STM studies of vortex cores in strongly confined nanoscale superconductors Type-1.5 superconductivity Direct visualization of vortex patterns in superconductors with competing vortex-vortex interactions Vortex dynamics in nanofabricated chemical solution deposition high-temperature superconducting films Artificial pinning sites and their applications Vortices at microwave frequencies Physics and operation of superconducting single-photon devices Josephson and charging effect in mesoscopic superconducting devices NanoSQUIDs: Basics & recent advances intrinsic Josephson junction stacks as emitters of terahertz radiation| Interference phenomena in superconductor-ferromagnet hybrids Spin-orbit interactions, spin currents, and magnetization dynamics in superconductor/ferromagnet hybrids Superconductor/ferromagnet hybrid
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