A MOSAIC of methods: Improving ortholog detection through integration of algorithmic diversity

Ortholog detection (OD) is a critical step for comparative genomic analysis of protein-coding sequences. In this paper, we begin with a comprehensive comparison of four popular, methodologically diverse OD methods: MultiParanoid, Blat, Multiz, and OMA. In head-to-head comparisons, these methods are shown to significantly outperform one another 12-30% of the time. This high complementarity motivates the presentation of the first tool for integrating methodologically diverse OD methods. We term this program MOSAIC, or Multiple Orthologous Sequence Analysis and Integration by Cluster optimization. Relative to component and competing methods, we demonstrate that MOSAIC more than quintuples the number of alignments for which all species are present, while simultaneously maintaining or improving functional-, phylogenetic-, and sequence identity-based measures of ortholog quality. Further, we demonstrate that this improvement in alignment quality yields 40-280% more confidently aligned sites. Combined, these factors translate to higher estimated levels of overall conservation, while at the same time allowing for the detection of up to 180% more positively selected sites. MOSAIC is available as python package. MOSAIC alignments, source code, and full documentation are available at http://pythonhosted.org/bio-MOSAIC

The System Kato: Detecting Cases of Plagiarism for Answer-Set Programs

Plagiarism detection is a growing need among educational institutions and solutions for different purposes exist. An important field in this direction is detecting cases of source-code plagiarism. In this paper, we present the tool Kato for supporting the detection of this kind of plagiarism in the area of answer-set programming (ASP). Currently, the tool is implemented for DLV programs but it is designed to handle other logic-programming dialects as well. We review the basic features of Kato, introduce its theoretical underpinnings, and discuss an application of Kato for plagiarism detection in the context of courses on logic programming at the Vienna University of Technology

Graph Symmetry Detection and Canonical Labeling: Differences and Synergies

Symmetries of combinatorial objects are known to complicate search algorithms, but such obstacles can often be removed by detecting symmetries early and discarding symmetric subproblems. Canonical labeling of combinatorial objects facilitates easy equivalence checking through quick matching. All existing canonical labeling software also finds symmetries, but the fastest symmetry-finding software does not perform canonical labeling. In this work, we contrast the two problems and dissect typical algorithms to identify their similarities and differences. We then develop a novel approach to canonical labeling where symmetries are found first and then used to speed up the canonical labeling algorithms. Empirical results show that this approach outperforms state-of-the-art canonical labelers.Comment: 15 pages, 10 figures, 1 table, Turing-10