Generating High Precision Classification Rules for Screening of Irrelevant Studies in Systematic Review Literature Searches

Systematic reviews aim to produce repeatable, unbiased, and comprehensive answers to clinical questions. Systematic reviews are an essential component of modern evidence based medicine, however due to the risks of omitting relevant research they are highly time consuming to create and are largely conducted manually. This thesis presents a novel framework for partial automation of systematic review literature searches. We exploit the ubiquitous multi-stage screening process by training the classifier using annotations made by reviewers in previous screening stages. Our approach has the benefit of integrating seamlessly with the existing screening process, minimising disruption to users. Ideally, classification models for systematic reviews should be easily interpretable by users. We propose a novel, rule based algorithm for use with our framework. A new approach for identifying redundant associations when generating rules is also presented. The proposed approach to redundancy seeks to both exclude redundant specialisations of existing rules (those with additional terms in their antecedent), as well as redundant generalisations (those with fewer terms in their antecedent). We demonstrate the ability of the proposed approach to improve the usability of the generated rules. The proposed rule based algorithm is evaluated by simulated application to several existing systematic reviews. Workload savings of up to 10% are demonstrated. There is an increasing demand for systematic reviews related to a variety of clinical disciplines, such as diagnosis. We examine reviews of diagnosis and contrast them against more traditional systematic reviews of treatment. We demonstrate existing challenges such as target class heterogeneity and high data imbalance are even more pronounced for this class of reviews. The described algorithm accounts for this by seeking to label subsets of non-relevant studies with high precision, avoiding the need to generate a high recall model of the minority class