43,157 research outputs found
Static Safety for an Actor Dedicated Process Calculus by Abstract Interpretation
The actor model eases the definition of concurrent programs with non uniform
behaviors. Static analysis of such a model was previously done in a data-flow
oriented way, with type systems. This approach was based on constraint set
resolution and was not able to deal with precise properties for communications
of behaviors. We present here a new approach, control-flow oriented, based on
the abstract interpretation framework, able to deal with communication of
behaviors. Within our new analyses, we are able to verify most of the previous
properties we observed as well as new ones, principally based on occurrence
counting
dotCall64: An Efficient Interface to Compiled C/C++ and Fortran Code Supporting Long Vectors
The R functions .C() and .Fortran() can be used to call compiled C/C++ and
Fortran code from R. This so-called foreign function interface is convenient,
since it does not require any interactions with the C API of R. However, it
does not support long vectors (i.e., vectors of more than 2^31 elements). To
overcome this limitation, the R package dotCall64 provides .C64(), which can be
used to call compiled C/C++ and Fortran functions. It transparently supports
long vectors and does the necessary castings to pass numeric R vectors to
64-bit integer arguments of the compiled code. Moreover, .C64() features a
mechanism to avoid unnecessary copies of function arguments, making it
efficient in terms of speed and memory usage.Comment: 17 page
Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces
At the heart of the structured architecture and complex dynamics of
biological systems are specific and timely interactions operated by
biomolecules. In many instances, biomolecular agents are spatially confined to
flexible lipid membranes where, among other functions, they control cell
adhesion, motility and tissue formation. Besides being central to several
biological processes, \emph{multivalent interactions} mediated by reactive
linkers confined to deformable substrates underpin the design of
synthetic-biological platforms and advanced biomimetic materials. Here we
review recent advances on the experimental study and theoretical modelling of a
heterogeneous class of biomimetic systems in which synthetic linkers mediate
multivalent interactions between fluid and deformable colloidal units,
including lipid vesicles and emulsion droplets. Linkers are often prepared from
synthetic DNA nanostructures, enabling full programmability of the
thermodynamic and kinetic properties of their mutual interactions. The coupling
of the statistical effects of multivalent interactions with substrate fluidity
and deformability gives rise to a rich emerging phenomenology that, in the
context of self-assembled soft materials, has been shown to produce exotic
phase behaviour, stimuli-responsiveness, and kinetic programmability of the
self-assembly process. Applications to (synthetic) biology will also be
reviewed.Comment: 63 pages, revie
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