A conceptual approach to gene expression analysis enhanced by visual analytics

The analysis of gene expression data is a complex task for biologists wishing to understand the role of genes in the formation of diseases such as cancer. Biologists need greater support when trying to discover, and comprehend, new relationships within their data. In this paper, we describe an approach to the analysis of gene expression data where overlapping groupings are generated by Formal Concept Analysis and interactively analyzed in a tool called CUBIST. The CUBIST workflow involves querying a semantic database and converting the result into a formal context, which can be simplified to make it manageable, before it is visualized as a concept lattice and associated charts

A Systematic Approach to Constructing Incremental Topology Control Algorithms Using Graph Transformation

Communication networks form the backbone of our society. Topology control algorithms optimize the topology of such communication networks. Due to the importance of communication networks, a topology control algorithm should guarantee certain required consistency properties (e.g., connectivity of the topology), while achieving desired optimization properties (e.g., a bounded number of neighbors). Real-world topologies are dynamic (e.g., because nodes join, leave, or move within the network), which requires topology control algorithms to operate in an incremental way, i.e., based on the recently introduced modifications of a topology. Visual programming and specification languages are a proven means for specifying the structure as well as consistency and optimization properties of topologies. In this paper, we present a novel methodology, based on a visual graph transformation and graph constraint language, for developing incremental topology control algorithms that are guaranteed to fulfill a set of specified consistency and optimization constraints. More specifically, we model the possible modifications of a topology control algorithm and the environment using graph transformation rules, and we describe consistency and optimization properties using graph constraints. On this basis, we apply and extend a well-known constructive approach to derive refined graph transformation rules that preserve these graph constraints. We apply our methodology to re-engineer an established topology control algorithm, kTC, and evaluate it in a network simulation study to show the practical applicability of our approachComment: This document corresponds to the accepted manuscript of the referenced journal articl

A Systematic Approach to Constructing Families of Incremental Topology Control Algorithms Using Graph Transformation

In the communication systems domain, constructing and maintaining network topologies via topology control (TC) algorithms is an important cross-cutting research area. Network topologies are usually modeled using attributed graphs whose nodes and edges represent the network nodes and their interconnecting links. A key requirement of TC algorithms is to fulfill certain consistency and optimization properties to ensure a high quality of service. Still, few attempts have been made to constructively integrate these properties into the development process of TC algorithms. Furthermore, even though many TC algorithms share substantial parts (such as structural patterns or tie-breaking strategies), few works constructively leverage these commonalities and differences of TC algorithms systematically. In previous work, we addressed the constructive integration of consistency properties into the development process. We outlined a constructive, model-driven methodology for designing individual TC algorithms. Valid and high-quality topologies are characterized using declarative graph constraints; TC algorithms are specified using programmed graph transformation. We applied a well-known static analysis technique to refine a given TC algorithm in a way that the resulting algorithm preserves the specified graph constraints. In this paper, we extend our constructive methodology by generalizing it to support the specification of families of TC algorithms. To show the feasibility of our approach, we reneging six existing TC algorithms and develop e-kTC, a novel energy-efficient variant of the TC algorithm kTC. Finally, we evaluate a subset of the specified TC algorithms using a new tool integration of the graph transformation tool eMoflon and the Simonstrator network simulation framework.Comment: Corresponds to the accepted manuscrip

Formally analysing the concepts of domestic violence.

The types of police inquiries performed these days are incredibly diverse. Often data processing architectures are not suited to cope with this diversity since most of the case data is still stored as unstructured text. In this paper Formal Concept Analysis (FCA) is showcased for its exploratory data analysis capabilities in discovering domestic violence intelligence from a dataset of unstructured police reports filed with the regional police Amsterdam-Amstelland in the Netherlands. From this data analysis it is shown that FCA can be a powerful instrument to operationally improve policing practice. For one, it is shown that the definition of domestic violence employed by the police is not always as clear as it should be, making it hard to use it effectively for classification purposes. In addition, this paper presents newly discovered knowledge for automatically classifying certain cases as either domestic or non-domestic violence is. Moreover, it provides practical advice for detecting incorrect classifications performed by police officers. A final aspect to be discussed is the problems encountered because of the sometimes unstructured way of working of police officers. The added value of this paper resides in both using FCA for exploratory data analysis, as well as with the application of FCA for the detection of domestic violence.Formal concept analysis (FCA); Domestic violence; Knowledge discovery in databases; Text mining; Exploratory data analysis; Knowledge enrichment; Concept discovery;