MildInt: Deep Learning-Based Multimodal Longitudinal Data Integration Framework

As large amounts of heterogeneous biomedical data become available, numerous methods for integrating such datasets have been developed to extract complementary knowledge from multiple domains of sources. Recently, a deep learning approach has shown promising results in a variety of research areas. However, applying the deep learning approach requires expertise for constructing a deep architecture that can take multimodal longitudinal data. Thus, in this paper, a deep learning-based python package for data integration is developed. The python package deep learning-based multimodal longitudinal data integration framework (MildInt) provides the preconstructed deep learning architecture for a classification task. MildInt contains two learning phases: learning feature representation from each modality of data and training a classifier for the final decision. Adopting deep architecture in the first phase leads to learning more task-relevant feature representation than a linear model. In the second phase, linear regression classifier is used for detecting and investigating biomarkers from multimodal data. Thus, by combining the linear model and the deep learning model, higher accuracy and better interpretability can be achieved. We validated the performance of our package using simulation data and real data. For the real data, as a pilot study, we used clinical and multimodal neuroimaging datasets in Alzheimer's disease to predict the disease progression. MildInt is capable of integrating multiple forms of numerical data including time series and non-time series data for extracting complementary features from the multimodal dataset

Response Characterization for Auditing Cell Dynamics in Long Short-term Memory Networks

In this paper, we introduce a novel method to interpret recurrent neural networks (RNNs), particularly long short-term memory networks (LSTMs) at the cellular level. We propose a systematic pipeline for interpreting individual hidden state dynamics within the network using response characterization methods. The ranked contribution of individual cells to the network's output is computed by analyzing a set of interpretable metrics of their decoupled step and sinusoidal responses. As a result, our method is able to uniquely identify neurons with insightful dynamics, quantify relationships between dynamical properties and test accuracy through ablation analysis, and interpret the impact of network capacity on a network's dynamical distribution. Finally, we demonstrate generalizability and scalability of our method by evaluating a series of different benchmark sequential datasets

Multichannel Attention Network for Analyzing Visual Behavior in Public Speaking

Public speaking is an important aspect of human communication and interaction. The majority of computational work on public speaking concentrates on analyzing the spoken content, and the verbal behavior of the speakers. While the success of public speaking largely depends on the content of the talk, and the verbal behavior, non-verbal (visual) cues, such as gestures and physical appearance also play a significant role. This paper investigates the importance of visual cues by estimating their contribution towards predicting the popularity of a public lecture. For this purpose, we constructed a large database of more than $1800$ TED talk videos. As a measure of popularity of the TED talks, we leverage the corresponding (online) viewers' ratings from YouTube. Visual cues related to facial and physical appearance, facial expressions, and pose variations are extracted from the video frames using convolutional neural network (CNN) models. Thereafter, an attention-based long short-term memory (LSTM) network is proposed to predict the video popularity from the sequence of visual features. The proposed network achieves state-of-the-art prediction accuracy indicating that visual cues alone contain highly predictive information about the popularity of a talk. Furthermore, our network learns a human-like attention mechanism, which is particularly useful for interpretability, i.e. how attention varies with time, and across different visual cues by indicating their relative importance