Named Entity Recognition for Bacterial Type IV Secretion Systems

Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological processes, cellular components, molecular functions, and microorganism species should improve the precision and recall of literature searches allowing researchers to keep up with the exponentially growing literature, through resources such as the Pathosystems Resource Integration Center (PATRIC, patricbrc.org). We developed named entity recognition (NER) tools for four entities related to Type IV secretion systems: 1) bacteria names, 2) biological processes, 3) molecular functions, and 4) cellular components. These four entities are important to pathogenesis and virulence research but have received less attention than other entities, e.g., genes and proteins. Based on an annotated corpus, large domain terminological resources, and machine learning techniques, we developed recognizers for these entities. High accuracy rates (>80%) are achieved for bacteria, biological processes, and molecular function. Contrastive experiments highlighted the effectiveness of alternate recognition strategies; results of term extraction on contrasting document sets demonstrated the utility of these classes for identifying T4SS-related documents

Prediction-based failure management for supercomputers

The growing requirements of a diversity of applications necessitate the deployment of large and powerful computing systems and failures in these systems may cause severe damage in every aspect from loss of human lives to world economy. However, current fault tolerance techniques cannot meet the increasing requirements for reliability. Thus new solutions are urgently needed and research on proactive schemes is one of the directions that may offer better efficiency. This thesis proposes a novel proactive failure management framework. Its goal is to reduce the failure penalties and improve fault tolerance efficiency in supercomputers when running complex applications. The proposed proactive scheme builds on two core components: failure prediction and proactive failure recovery. More specifically, the failure prediction component is based on the assessment of system events and employs semi-Markov models to capture the dependencies between failures and other events for the forecasting of forthcoming failures. Furthermore, a two-level failure prediction strategy is described that not only estimates the future failure occurrence but also identifies the specific failure categories. Based on the accurate failure forecasting, a prediction-based coordinated checkpoint mechanism is designed to construct extra checkpoints just before each predicted failure occurrence so that the wasted computational time can be significantly reduced. Moreover, a theoretical model has been developed to assess the proactive scheme that enables calculation of the overall wasted computational time.The prediction component has been applied to industrial data from the IBM BlueGene/L system. Results of the failure prediction component show a great improvement of the prediction accuracy in comparison with three other well-known prediction approaches, and also demonstrate that the semi-Markov based predictor, which has achieved the precision of 87.41% and the recall of 77.95%, performs better than other predictors.EThOS - Electronic Theses Online ServiceGBUnited Kingdo