Registration Pluralism and the Cartographic Approach to Data Aggregation Across Brains

Neuroscience has become increasingly reliant on multi-subject research in addition to studies of unusual single patients. This research has brought with it a challenge: how are data from different human brains to be combined? The dominant strategy for aggregating data across brains is what I call ‘the cartographic approach’, which involves mapping data from individuals to a spatial template. Here I characterize the cartographic approach and argue that one of its key steps, registration, should be carried out in a way that is sensitive to the target of investigation. Because registration aims to align homologous brain locations, but not all homologous locations can be simultaneously aligned, a multiplicity of registration methods is required to meet the needs of researchers investigating different phenomena. I call this position ‘registration pluralism’. Registration pluralism has potential implications for neuroscientific practice, three of which I discuss here. This work shows the importance of reflecting more carefully on data aggregation methods, especially in light of the substantial individual differences that exist between brains

Registration Pluralism and the Cartographic Approach to Data Aggregation Across Brains

Neuroscience has become increasingly reliant on multi-subject research in addition to studies of unusual single patients. This research has brought with it a challenge: how are data from different human brains to be combined? The dominant strategy for aggregating data across brains is what I call ‘the cartographic approach’, which involves mapping data from individuals to a spatial template. Here I characterize the cartographic approach and argue that one of its key steps, registration, should be carried out in a way that is sensitive to the target of investigation. Because registration aims to align homologous brain locations, but not all homologous locations can be simultaneously aligned, a multiplicity of registration methods is required to meet the needs of researchers investigating different phenomena. I call this position ‘registration pluralism’. Registration pluralism has potential implications for neuroscientific practice, three of which I discuss here. This work shows the importance of reflecting more carefully on data aggregation methods, especially in light of the substantial individual differences that exist between brains

Individual Differences in Cognitive Science: Conceptual and Methodological Issues

A primary aim of cognitive science is the investigation of psychological and neuroscientific generalizations that hold across subjects. Individual differences between people’s minds and brains are pervasive, however, even among subjects considered neurotypical. In this dissertation, I argue that both scientific practice and our philosophical understanding of science must be updated to reflect the presence of such individual differences. The first half of the dissertation proposes and applies a philosophical account of what it takes to explain variation, while the second half identifies several methods in psychology and neuroscience that demand reform in light of existing individual differences