Distributed-memory parallelization of an explicit time-domain volume integral equation solver on Blue Gene/P

Two distributed-memory schemes for efficiently parallelizing the explicit marching-on in-time based solution of the time domain volume integral equation on the IBM Blue Gene/P platform are presented. In the first scheme, each processor stores the time history of all source fields and only the computationally dominant step of the tested field computations is distributed among processors. This scheme requires all-to-all global communications to update the time history of the source fields from the tested fields. In the second scheme, the source fields as well as all steps of the tested field computations are distributed among processors. This scheme requires sequential global communications to update the time history of the distributed source fields from the tested fields. Numerical results demonstrate that both schemes scale well on the IBM Blue Gene/P platform and the memory efficient second scheme allows for the characterization of transient wave interactions on composite structures discretized using three million spatial elements without an acceleration algorithm

Special Libraries, October 1960

Volume 51, Issue 8https://scholarworks.sjsu.edu/sla_sl_1960/1007/thumbnail.jp

Depression in patients with Type 2 Diabetes in Maltese primary care

Background: Type 2 diabetes and depression are two common chronic conditions affecting the Maltese population with significant and costly effects on health. Multiple studies have demonstrated a higher prevalence of depression in diabetic patients and a link with uncontrolled diabetes; however, despite this, depression is still not considered as important to chronic conditions in terms of the effects it has on health. -- Objectives: This study was conducted to estimate the prevalence of depression in type 2 diabetic patients in primary care and to study their associated risk factors. -- Method: A quantitative, cross-sectional, retrospective, descriptive study was performed among 400 participants with type 2 diabetes attending diabetes clinics within the public health centres in Malta. Patients completed a self-administered questionnaire to quantify depressive symptoms and to study patient and disease characteristics. Convenience sampling was used to collect the data. -- Results: Data analysis showed that the prevalence of depression is around 29.7% among type 2 diabetic patients. Younger diabetics, women, lower educational levels, unemployment, obesity, a family history of depression and uncontrolled diabetes were found to be associated with a higher risk of developing depressive symptoms. -- Conclusions: Screening for depression in type 2 diabetic patients is important due to the high prevalence and significant impact on health. Appropriate management can significantly improve the outcome of both conditions and consequently improve both health and quality of life.peer-reviewe

Special Libraries, October 1960

Volume 51, Issue 8https://scholarworks.sjsu.edu/sla_sl_1960/1007/thumbnail.jp

The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers

Many inhibitor of apoptosis (IAP) family proteins inhibit apoptosis. IAPs contain N-terminal baculovirus IAP repeat domains and a C-terminal RING ubiquitin ligase domain. Drosophila IAP DIAP1 is essential for the survival of many cells, protecting them from apoptosis by inhibiting active caspases. Apoptosis initiates when proteins such as Reaper, Hid, and Grim bind a surface groove in DIAP1 baculovirus IAP repeat domains via an N-terminal IAP-binding motif. This evolutionarily conserved interaction disrupts DIAP1-caspase interactions, unleashing apoptosis-inducing caspase activity. A second Drosophila IAP, DIAP2, also binds Rpr and Hid and inhibits apoptosis in multiple contexts when overexpressed. However, due to a lack of mutants, little is known about the normal functions of DIAP2. We report the generation of diap2 null mutants. These flies are viable and show no defects in developmental or stress-induced apoptosis. Instead, DIAP2 is required for the innate immune response to Gram-negative bacterial infection. DIAP2 promotes cytoplasmic cleavage and nuclear translocation of the NF-{kappa}B homolog Relish, and this requires the DIAP2 RING domain. Increasing the genetic dose of diap2 results in an increased immune response, whereas expression of Rpr or Hid results in down-regulation of DIAP2 protein levels. Together these observations suggest that DIAP2 can regulate immune signaling in a dose-dependent manner, and this can be regulated by IBM-containing proteins. Therefore, diap2 may identify a point of convergence between apoptosis and immune signaling pathways

Special Libraries, February 1962

Volume 53, Issue 2https://scholarworks.sjsu.edu/sla_sl_1962/1001/thumbnail.jp