475,447 research outputs found
Discovering study-specific gene regulatory networks
This article has been made available through the Brunel Open Access Publishing Fund.Microarrays are commonly used in biology because of their ability to simultaneously measure thousands of genes under different conditions. Due to their structure, typically containing a high amount of variables but far fewer samples, scalable network analysis techniques are often employed. In particular, consensus approaches have been recently used that combine multiple microarray studies in order to find networks that are more robust. The purpose of this paper, however, is to combine multiple microarray studies to automatically identify subnetworks that are distinctive to specific experimental conditions rather than common to them all. To better understand key regulatory mechanisms and how they change under different conditions, we derive unique networks from multiple independent networks built using glasso which goes beyond standard correlations. This involves calculating cluster prediction accuracies to detect the most predictive genes for a specific set of conditions. We differentiate between accuracies calculated using cross-validation within a selected cluster of studies (the intra prediction accuracy) and those calculated on a set of independent studies belonging to different study clusters (inter prediction accuracy). Finally, we compare our method's results to related state-of-the art techniques. We explore how the proposed pipeline performs on both synthetic data and real data (wheat and Fusarium). Our results show that subnetworks can be identified reliably that are specific to subsets of studies and that these networks reflect key mechanisms that are fundamental to the experimental conditions in each of those subsets
The Evolution of Wikipedia's Norm Network
Social norms have traditionally been difficult to quantify. In any particular
society, their sheer number and complex interdependencies often limit a
system-level analysis. One exception is that of the network of norms that
sustain the online Wikipedia community. We study the fifteen-year evolution of
this network using the interconnected set of pages that establish, describe,
and interpret the community's norms. Despite Wikipedia's reputation for
\textit{ad hoc} governance, we find that its normative evolution is highly
conservative. The earliest users create norms that both dominate the network
and persist over time. These core norms govern both content and interpersonal
interactions using abstract principles such as neutrality, verifiability, and
assume good faith. As the network grows, norm neighborhoods decouple
topologically from each other, while increasing in semantic coherence. Taken
together, these results suggest that the evolution of Wikipedia's norm network
is akin to bureaucratic systems that predate the information age.Comment: 22 pages, 9 figures. Matches published version. Data available at
http://bit.ly/wiki_nor
The Hall of Mirrors Perceptions and Misperceptions in the Congressional Foreign Policy Process
Explores several factors related to an inconsistency in the voting record by the U.S. Congress on foreign policy issues, compared with the position taken by the public, administration officials, and leaders in business, labor, media, and education
Sustainable Development Report: Blockchain, the Web3 & the SDGs
This is an output paper of the applied research that was conducted between July 2018 - October 2019 funded by the Austrian Development Agency (ADA) and conducted by the Research Institute for Cryptoeconomics at the Vienna University of Economics and Business and RCE Vienna (Regional Centre of Expertise on Education for Sustainable Development).Series: Working Paper Series / Institute for Cryptoeconomics / Interdisciplinary Researc
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