Potentzia domeinuko NOMA 5G sareetarako eta haratago

Tesis inglés 268 p. -- Tesis euskera 274 p.During the last decade, the amount of data carried over wireless networks has grown exponentially. Several reasons have led to this situation, but the most influential ones are the massive deployment of devices connected to the network and the constant evolution in the services offered. In this context, 5G targets the correct implementation of every application integrated into the use cases. Nevertheless, the biggest challenge to make ITU-R defined cases (eMBB, URLLC and mMTC) a reality is the improvement in spectral efficiency. Therefore, in this thesis, a combination of two mechanisms is proposed to improve spectral efficiency: Non-Orthogonal Multiple Access (NOMA) techniques and Radio Resource Management (RRM) schemes. Specifically, NOMA transmits simultaneously several layered data flows so that the whole bandwidth is used throughout the entire time to deliver more than one service simultaneously. Then, RRM schemes provide efficient management and distribution of radio resources among network users. Although NOMA techniques and RRM schemes can be very advantageous in all use cases, this thesis focuses on making contributions in eMBB and URLLC environments and proposing solutions to communications that are expected to be relevant in 6G

Resource assignment in short life technology intensive (SLTI) new product development (NPD)

Enterprises managing multiple concurrent New Product Development (NPD) projects face significant challenges assigning staff to projects in order to achieve launch schedules that maximize financial returns. The challenge is increased with the class of Short Life Technology Intensive (SLTI) products characterized by technical complexity, short development cycles and short revenue life cycles. Technical complexity drives the need to assign staffing resources of various technical disciplines and skill levels. SLTI products are rapidly developed and launched into stationary market windows where the revenue life cycle is short and decreasing with any time-to-market delay. The SLTI-NPD project management decision is to assign staff of varying technical discipline and skill level to minimize the revenue loss due to product launch delays across multiple projects. This dissertation considers an NPD organization responsible for multiple concurrent SLTI projects each characterized by a set of tasks having technical discipline requirements, task duration estimates and logical precedence relationships. Each project has a known potential launch date and potential revenue life cycle. The organization has a group of technical professionals characterized by a range of skill levels in a known set of technical disciplines. The SLTI-NPD resource assignment problem is solved using a multi-step process referred to as the Resource Assignment and Multi-Project Scheduling (RAMPS) decision support tool. Robust scheduling techniques are integrated to develop schedules that consider variation in task and project duration estimates. A valuation function provides a time-value linkage between schedules and the product revenue life cycle for each product. Productivity metrics are developed as the basis for prioritizing projects for resources assignment. The RAMPS tool implements assignment and scheduling algorithms in two phases; (i) a constructive approach that employs priority rule heuristics to derive feasible assignments and schedules and (ii) an improvement heuristic that considers productivity gains that can be achieved by interchanging resources of differing skill levels and corresponding work rates. An experimental analysis is conducted using the RAMPS tool and simulated project and resource data sets. Results show significant productivity and efficiency gains that can be achieved through effective project and resource prioritization and by including consideration of skill level in the assignment of technical resources

Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects

Regular Abstracts - Tuesday Poster Presentations: no. 1925Metaphase describes a phase of mitosis where chromosomes are attached and oriented on the bipolar spindle for subsequent segregation at anaphase. In diverse cell types, the metaphase spindle is maintained at a relatively constant length. Metaphase spindle length is proposed to be regulated by a balance of pushing and pulling forces generated by distinct sets of spindle microtubules and their interactions with motors and microtubule-associated proteins (MAPs). Spindle length appears important for chromosome segregation fidelity, as cells with shorter or longer than normal metaphase spindles, generated through deletion or inhibition of individual mitotic motors or MAPs, showed chromosome segregation defects. To test the force balance model of spindle length control and its effect on chromosome segregation, we applied fast microfluidic temperature-control with live-cell imaging to monitor the effect of switching off different combinations of antagonistic forces in the fission yeast metaphase spindle. We show that spindle midzone proteins kinesin-5 cut7p and microtubule bundler ase1p contribute to outward pushing forces, and spindle kinetochore proteins kinesin-8 klp5/6p and dam1p contribute to inward pulling forces. Removing these proteins individually led to aberrant metaphase spindle length and chromosome segregation defects. Removing these proteins in antagonistic combination rescued the defective spindle length and, in some combinations, also partially rescued chromosome segregation defects. Our results stress the importance of proper chromosome-to-microtubule attachment over spindle length regulation for proper chromosome segregation.postprin

Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin