A reproducible approach with R markdown to automatic classification of medical certificates in French

In this paper, we report the ongoing developments of our first participation to the Cross-Language Evaluation Forum (CLEF) eHealth Task 1: “Multilingual Information Extraction - ICD10 coding” (Névéol et al., 2017). The task consists in labelling death certificates, in French with international standard codes. In particular, we wanted to accomplish the goal of the ‘Replication track’ of this Task which promotes the sharing of tools and the dissemination of solid, reproducible results.In questo articolo presentiamo gli sviluppi del lavoro iniziato con la partecipazione al Laboratorio CrossLanguage Evaluation Forum (CLEF) eHealth denominato: “Multilingual Information Extraction - ICD10 coding” (Névéol et al., 2017) che ha come obiettivo quello di classificare certificati di morte in lingua francese con dei codici standard internazionali. In particolare, abbiamo come obiettivo quello proposto dalla ‘Replication track’ di questo Task, che promuove la condivisione di strumenti e la diffusione di risultati riproducibili

Print information to inform decisions about mammography screening participation in 16 countries with population-based programs

OBJECTIVE: To profile and compare the content and presentation of written communications related to informed decision-making about mammography. METHODS: Materials from 16 screening programs organized at the national or regional level were analyzed according to five major information domains suggested by the international literature. RESULTS: A majority of countries provided information on the program (interval, cost and quality). There was considerable variability in comprehensiveness of elements in the domains, e.g., test characteristics (false positive/negative) and pros and cons of screening. The majority noted the likelihood of recall for further tests, few commented on the risks of additional tests or finding unimportant tumors. The audit also found variation in presentation (words and pictures). CONCLUSIONS: Presentation of comprehensive, but balanced information on screening benefits and risks is complex and daunting. Issues such as framing effects, coupled with debate about screening efficacy are challenging to the design of effective information tools. The objective of increasing screening prevalence at the population level must be balanced with objectively presenting complete and clear information. Additional research is needed on how information (and mode of presentation) impact screening decisions. PRACTICE IMPLICATIONS: Public health officials need to articulate their objectives and review written communication according to important decision-making domains. [Authors]]]> Decision Making ; Informed Consent ; Mammography ; Mass Screening ; Patient Acceptance of Health Care ; Patient Education as Topic oai:serval.unil.ch:BIB_E228BFDB52E0 2022-05-07T01:28:47Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E228BFDB52E0 Evaluation médico-économique de la thrombolyse de l'accident vasculaire cérébral hyperaigu par le rtPA (Actilyse) http://www.chuv.ch/bdfm/cdsp/MemoireBonvin.pdf Bonvin, Marielle Université de Lausanne, Faculté des hautes études commerciales masterthesis 2003 <![CDATA[L'AVC (accident vasculaire cérébral) représente la troisième cause de mortalité et la première cause de handicap fonctionnel chronique dans la population adulte occidentale. Son fardeau économique compte parmi les plus élevés de toutes les maladies. Ce mémoire a pour objet d'étudier l'impact économique d'une nouvelle procédure d'intervention, la thrombolyse des infarctus cérébraux par le rtPA, sur les coûts du Centre hospitalier universitaire vaudois. [Table des matières] 1. Introduction. 2. Physiopathologie et traitement de l'accident vasculaire cérébral : 2.1 Mécanismes de la coagulation sanguine 2.2 L'athérosclérose. 2.3 L'infarctus cérébral. 2.4 Les traitements de l'AVC. 2.5 La controverse. 2.6 La situation au CHUV. 2.7 Les enjeux économiques. 3. Méthodologie. 4. Tableaux : caractéristiques de l'échantillon et résultats. 5. Discussion. 6. Limites de l'étude. 7. Conclusion

Liever inleiden dan afwachten bij aterme zwangerschapshypertensie en milde preeclampsie: HYPITAT-studie

OBJECTIVE: To investigate what would benefit women with mild full-term pregnancy-related hypertension most: induction of labour or expectant monitoring, from the perspective of clinical effectiveness, maternal quality of life, and costs. DESIGN: Randomised clinical trial. Trial registration number ISRCTN08132825. METHODS: We undertook a multicentre randomised controlled trial in 38 hospitals in the Netherlands between October 2005 and March 2008. We enrolled patients with a singleton pregnancy in cephalic presentation at 36-41 weeks' gestation, who had gestational hypertension or mild preeclampsia. Participants were randomly allocated to receive either induction of labour or expectant monitoring. The primary outcome was a composite measure of poor maternal outcome, defined as maternal mortality, maternal morbidity (eclampsia, 'haemolysis, elevated liver enzymes, low platelets' (HELLP) syndrome, pulmonary oedema, thrombo-embolic disease and abruptio placentae), progression to severe hypertension or proteinuria, and major postpartum haemorrhage. Secondary outcomes were mode of delivery, neonatal outcome, maternal quality of life and costs. Analysis was by intention to treat. RESULTS: A total of 756 patients were allocated to receive induction of labour (n = 377 patients) or expectant monitoring (n = 379). No cases of maternal or neonatal death or eclampsia were recorded. Development of poor maternal outcome was significantly lower in the induction of labour group (117 women) than the expectant monitoring group (166 women) (31% versus 44%; relative risk 0.71 (95% CI: 0.59-0.86); p < 0.001). The caesarean section rate was lower among women in the induction of labour group (n = 54) compared to women in the expectant monitoring group (n = 72) (14% versus 19%; relative risk 0.75 (95% CI: 0.55-1.04)< p = 0.085). Neonatal outcomes and quality of life were comparable between both groups. Induction of labour is a cost saving strategy (difference euro 831). CONCLUSION: For women with full-term gestational hypertension and pre-eclampsia, induction of labour is associated with improved maternal outcome and lower costs, without the additional risk of a caesarean section being necessary

LA TRANSPLANTATION HÉPATIQUE ORTHOTOPIQUE À L'UNIVERSITÉ DU COLORADO.

Ce travail a été réalisé grâce aux fonds de recherche de la Veterans Administration, aux fonds RR-00051 et RR-00069 du programme des centres de recherche clinique générale de la Division of Research Resources, National Institutes of Health, et aux fonds AI-10176-01, AI-AM-08898, et AM-07772

Показания к первому переливанию эритроцитов у пациентов с верхними желудочно-кишечными кровотечениями с учетом их генетической конституции

Сьогодні персоніфікований підхід проникає у щоденну трансфузійну практику. Кожний хворий на верхню шлунково-кишкову кровотечу повинен одержати окреме індивідуально підібране показання до трансфузійної терапії. Мета роботи – розробити показання до першого переливання еритроцитів у хворих на верхню шлунково-кишкову кровотечу різної етіології. Матеріали і методи. 10 пацієнтів з гострими верхніми шлунко-во-кишковими кровотечами було вивчено у Сумській обласній клінічній лікарні та Сумському державному університеті. Використано аналіз post hoc та полімеразну ланцюгову реакцію для генного поліморфізму ESR1/rs2234693. Результати. Нова трансфузійна схема подана. Перша трансфузія еритроцитів показана для компенсації виразкових та варикозних кровотеч, якщо діагностика гемостатичного контролю, серцево-судинний анамнез та інформація генотипування були відповідно визначені та оцінені. Висновки. Перша трансфузія еритроцитів при гемоглобінемії між ≤ 70 та 100 г/л є індивідуально ефективною, якщо клінічний висновок для трансфузії включає оцінювання генотипу. Таку стратегію необхідно оцінити у майбутніх клінічних випробуваннях.Введение. Сегодня персонифицированный подход проникает в ежедневную трансфузионную практику. Каждый пациент с верхним желудочно-кишечным кровотечением должен иметь определенное индивидуально подобранное показание для трансфузионной терапии. Цель работы – разработать показания к первой трансфузии эритроцитов для пациентов с верхними желудочно-кишечными кровотечениями различной этиологии. Материалы и методы.В Сумской областной клинической больнице и Сумском государственном университете изучено 10 пациентов с верхними желудочно-кишечными кровотечениями. Использован для пациентов метод анализа post hoc и полимеразной цепной реакции для полиморфизма гена ESR1/rs2234693. Результаты. Новая трансфузионная схема представлена. Первое переливание эритроцитов показано для компенсации кровотечения язвенной или варикозной этиологии, если диагностика относительно гемостатического контроля, сердечно-сосудистый анамнез и информация о генотипировании соответственно определены и рассмотрены. Выводы. Первое переливание эритроцитов при гемоглобинемии между ≤ 70 и 100 г/л является индивидуально эффективным, когда клиническое принятие решения о трансфузии включает генотипирование и его оценку. Такая стратегия должна быть оценена в клинических испытаниях.Background. Today a personified approach may penetrate in a daily transfusion practice. Every patient with upper gastrointestinal bleeding should have a clear and individually selected indication for transfusion therapy. Objective – to develop indications for the first erythrocyte transfusion for patients with upper gastrointestinal bleedings of different origin. Materials and methods. A total of 10 patients with acute with upper gastrointestinal bleeding were studied in Sumy Regional Clinical Hospital and Sumy State University. The polymerase chain reaction method for ESR1/rs2234693 gene polymorphism of patients and the post hoc analysis were implemented. Results. A new transfusion scheme was presented. The first erythrocyte transfusion was indicated to compensate ulcer and variceal bleedings, if diagnostics of haemostasis control, cardiovascular history and genotyping information were appropriately fixed and considered. Conclusion. The first erythrocyte transfusion under the haemoglobinemia between ≤ 70 and 100 g/L may be individually effective when the clinical decision-making process for transfusion indication includes genotyping assessment. This strategy should be assessed in a future clinical trial