Deep generative modeling for single-cell transcriptomics.

Single-cell transcriptome measurements can reveal unexplored biological diversity, but they suffer from technical noise and bias that must be modeled to account for the resulting uncertainty in downstream analyses. Here we introduce single-cell variational inference (scVI), a ready-to-use scalable framework for the probabilistic representation and analysis of gene expression in single cells ( https://github.com/YosefLab/scVI ). scVI uses stochastic optimization and deep neural networks to aggregate information across similar cells and genes and to approximate the distributions that underlie observed expression values, while accounting for batch effects and limited sensitivity. We used scVI for a range of fundamental analysis tasks including batch correction, visualization, clustering, and differential expression, and achieved high accuracy for each task

Enhanced manufacturing storage management using data mining prediction techniques

Performing an efficient storage management is a key issue for reducing costs in the manufacturing process. And the first step to accomplish this task is to have good estimations of the consumption of every storage component. For making accurate consumption estimations two main approaches are possible: using past utilization values (time series); and/or considering other external factors affecting the spending rates. Time series forecasting is the most common approach due to the fact that not always is clear the causes affecting consumption. Several classical methods have extensively been used, mainly ARIMA models. As an alternative, in this paper it is proposed to use prediction techniques based on the data mining realm. The use of consumption prediction algorithms clearly increases the storage management efficiency. The predictors based on data mining can offer enhanced solutions in many cases.Telefónica, through the “Cátedra de Telefónica Inteligencia en la Red”Paloma Luna Garrid