21,005 research outputs found

    Investigating a Frisian Genetic Mutation

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    GA-based tuning of nonlinear observers for sensorless control of IPMSMs

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    The paper considers two observer-based rotor position estimation schemes for sensorless control of interior permanent magnet synchronous machines (IPMSMs). Emphasis is given to techniques based on feedback linearisation followed by Luenberger observer design, and direct design of nonlinear observers. Genetic algorithms (GAs) based on the principles of evolution, natural selection and genetic mutation are employed to address difficulties in selecting correction gains for the observers, since no analytical tuning mechanisms yet exist, with results included to demonstrate the enhanced performance attributes offered by observers tuned in this way

    GA-tuning of nonlinear observers for sensorless control of automotive power steering IPMSMs

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    The paper considers two observer-based rotor position estimation schemes for sensorless control of interior permanent magnet synchronous motors (IPMSMs) for use in future automotive power steering systems. Specifically, emphasis is given to techniques based on feedback-linearisation followed by classical Luenberger observer design, and direct design of non-linear observers. Genetic algorithms (GAs), using the principles of evolution, natural selection and genetic mutation, are introduced to address difficulties in selecting correction gains for the observers, since no analytical tuning mechanisms yet exist. Experimental measurements from an automotive power steering test-facility are included, to demonstrate the enhanced performance attributes offered by tuning the proposed observer schemes, online, in this manner

    Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency

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    Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair deficiency (UMMRD, also known as mutation-negative Lynch syndrome). Comprehensive genetic testing that could potentially further clarify Lynch syndrome (LS) carrier status is essential to provide tailored screening guidelines to affected individuals and their family members; however, patient understanding of the potential impact of updated genetic testing for LS is unclear. This study aimed to evaluate the interest in and perceived impact of updated genetic testing among individuals with UMMRD at a tertiary academic center. A survey evaluating interest in updated genetic testing was mailed to 98 potential participants, and an electronic health record review was completed for the 31 individuals who returned the survey. Results indicate that this population is highly interested in updated genetic testing, and their perceived impact is primarily for family members to have appropriate testing and screening options. Updated risk assessment and genetic counseling, along with a discussion of the benefits and limitations of genetic testing, is essential as the understanding of potential causes of UMMRD evolves. Updated genetic counseling may allow patients with UMMRD to better understand the interpretation of their tumor and germline testing, as well as the impact of comprehensive genetic testing for themselves and their family members

    Exploring the Development of Core Teaching Practices in the Context of Inquiry-based Science Instruction: An Interpretive Case Study

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    This paper describes our reflection on a clinical-based teacher preparation program. We examined a context in which novice pre-service teachers and a mentor teacher implemented inquiry-based science instruction to help students make sense of genetic engineering. We utilized developmental models of professional practice that outline the complexity inherent in professional knowledge as a conceptual framework to analyze teacher practice. Drawing on our analysis, we developed a typography of understandings of inquiry-based science instruction that teachers in our cohort held and generated a two dimensional model characterizing pathways through which teachers develop core teaching practices supporting inquiry-based science instruction

    Is Plantinga a Friend of Evolutionary Science?

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    I Cut Off My... Voice: An Autoethnography of an Artist and Art Educator with a BRCA Genetic Mutation

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    The effects of BRCA genetic mutations on artists and art educators had not been known. Autoethnography is a qualitative method for writing about personal experiences through a cultural lens. I used my personal experiences within a BRCA positive community to understand shared experiences among artists and art educators with this genetic mutation. This study aimed to explore the commonalities that are occurring within this subgroup. Anxiety and emotional stress played a role in most of the respondents‟ lives, affecting them in numerous ways. Most of the respondents underwent salpingectomy, oophorectomy, and mastectomy surgeries which led to further emotional and physical stressors. All respondents voiced that they were determined to take control over their lives, whether that was through surgeries or continued preventative testing. The arts can empower many with a BRCA genetic mutation to share their stories and let their voices be heard. Keywords: autoethnography, BRCA, genetic mutation, artist, art educator, salpingectomy, oophorectomy, mastectomy, emotional, physical, empowerment, art

    A Critique of Alvin Plantinga’s Speech: ‘’Science and Religion: Where the Conflict Really Lies?’’

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    This article aims to examine Alvin Plantinga's speech at Biola University which name is: ‘‘Science and Religion, Where the Conflict Really Lies.’’ In order to achieve this purpose, after giving a description of the emergence of conflict between two disciplines, the ideas of Plantinga is examined through his speech and articles. The remainder of the article conducts a critical examination of his thesis in the light of Islamic viewpoint
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