Genetic Algorithm based Fuzzy Multiple Regression for the Nocturnal Hypoglycaemia Detection

Low blood glucose (Hypoglycaemia) is dangerous and can result in unconsciousness, seizures and even death. It has a common and serious side effect of insulin therapy in patients with diabetes. We measure physiological parameters (heart rate, corrected QT interval of the electrocardiogram (ECG) signal, change of heart rate, and the change of corrected QT interval) continuously to provide detection of hypoglycaemic. Based on these physiological parameters, we have developed a genetic algorithm based multiple regression model to determine the presence of hypoglycaemic episodes. Genetic algorithm is used to determine the optimal parameters of the multiple regression. The overall data were organized into a training set (8 patients) and a testing set (another 8 patient) which are randomly selected. The clinical results show that the proposed algorithm can achieve predictions with good sensitivities and acceptable specificities

EDMON - Electronic Disease Surveillance and Monitoring Network: A Personalized Health Model-based Digital Infectious Disease Detection Mechanism using Self-Recorded Data from People with Type 1 Diabetes

Through time, we as a society have been tested with infectious disease outbreaks of different magnitude, which often pose major public health challenges. To mitigate the challenges, research endeavors have been focused on early detection mechanisms through identifying potential data sources, mode of data collection and transmission, case and outbreak detection methods. Driven by the ubiquitous nature of smartphones and wearables, the current endeavor is targeted towards individualizing the surveillance effort through a personalized health model, where the case detection is realized by exploiting self-collected physiological data from wearables and smartphones. This dissertation aims to demonstrate the concept of a personalized health model as a case detector for outbreak detection by utilizing self-recorded data from people with type 1 diabetes. The results have shown that infection onset triggers substantial deviations, i.e. prolonged hyperglycemia regardless of higher insulin injections and fewer carbohydrate consumptions. Per the findings, key parameters such as blood glucose level, insulin, carbohydrate, and insulin-to-carbohydrate ratio are found to carry high discriminative power. A personalized health model devised based on a one-class classifier and unsupervised method using selected parameters achieved promising detection performance. Experimental results show the superior performance of the one-class classifier and, models such as one-class support vector machine, k-nearest neighbor and, k-means achieved better performance. Further, the result also revealed the effect of input parameters, data granularity, and sample sizes on model performances. The presented results have practical significance for understanding the effect of infection episodes amongst people with type 1 diabetes, and the potential of a personalized health model in outbreak detection settings. The added benefit of the personalized health model concept introduced in this dissertation lies in its usefulness beyond the surveillance purpose, i.e. to devise decision support tools and learning platforms for the patient to manage infection-induced crises