Human Rights Questions: From Bioethics to Biolaw

Bioethics as a pluridisciplinary activity aims to clarify and solve actual ethical problems generated by science and bio-medical technologies. The gap between the scientific and medical progress and the law generally and Human Rights especially does not allow immediate answers to many questions (related to medically assisted reproduction, euthanasia, organ transplantation, genetic therapy etc). Biolaw has to find legal answers. Since the states have different juridical solutions to bioethical problems the uniformization at least at the level of the European Union is a necessity.Human rights,Bioethics,genetic therapy

Modulator Therapy for Cystic Fibrosis: An Exploration of Current Research

Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began searching for small organic molecules that could act as chaperones for CFTR. These molecules, known as modulators, allowed CFTR to be assembled correctly and function similarly to wild type CFTR. Since 2012, four modulator drugs have been developed, tested, and approved by the FDA. In October 2019, Trikafta was approved as the first triple-combination modulator drug and has completely revolutionized CF therapy. This paper details the research challenges, successes, and failures that led to the development of modulator therapies

On Sin, Repentance, Christian Nurture, And The Genetics of Personality

Dean Homer\'s description of the genetics of personality includes two components: temperament and character. Temperament is a product of the interaction of the individual\'s genes with early stimuli, whereas character is formed by parenting, social interaction and the individual\'s choices of reactions to external stimuli throughout life. This understanding of the genetics ofpersonality argues against determinism and is appropriate for a Christian doctrine of sin and repentance. Hamcr\'s description of the impact of child-rearing on character echoes the significance of Christian nurture, especially as expressed in the Sacrament of Baptism

Genetic Therapy Approaches for Ornithine Transcarbamylase Deficiency

Ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle disorder with high unmet needs, as current dietary and medical treatments may not be sufficient to prevent hyperammonemic episodes, which can cause death or neurological sequelae. To date, liver transplantation is the only curative choice but is not widely available due to donor shortage, the need for life-long immunosuppression and technical challenges. A field of research that has shown a great deal of promise recently is gene therapy, and OTCD has been an essential candidate for different gene therapy modalities, including AAV gene addition, mRNA therapy and genome editing. This review will first summarise the main steps towards clinical translation, highlighting the benefits and challenges of each gene therapy approach, then focus on current clinical trials and finally outline future directions for the development of gene therapy for OTCD

Gene Therapy – Potential, Pros, Cons and Ethics

Genetic technology poses risks along with its rewards, just as any technology has in the past. To stop its development and forfeit the benefits gene therapy could offer would be a far greater mistake than forging ahead could ever be. People must always try to be responsible with their new technology, but gene therapy has the potential to be the future of medicine and its possibilities must be explored

Visions of a Martian Future

As we look beyond our terrestrial boundary to a multi-planetary future for humankind, it becomes paramount to anticipate the challenges of various human factors on the most likely scenario for this future: permanent human settlement of Mars. Even if technical hurdles are circumvented to provide adequate resources for basic physiological and psychological needs, Homo sapiens will not survive on an alien planet if a dysfunctional psyche prohibits the utilization of these resources. No matter how far we soar into the stars, our psychologies for future generations will be forever tethered to the totality of our surroundings. By shaping our environment toward survival and welfare during the voyage to Mars and in a Martian colony, we indirectly shape our psyches and prepare them for a mission of unprecedented alienation and duration. Once on Mars, human factors such as leadership structure, social organization and code of conduct, group size, gender balance, developmental cycle, mobility, length of stay and the ecological settings and type and manner of subsistence, will create a novel Martian culture. The degree that settlers are severed from the Earth will affect how radically foreign this culture will be when compared with cultures on Earth