Modelización y analisis del efecto de las arrítmias auriculares sobre la respuesta ventricular

La principal motivación del presente proyecto es profundizar en el comportamiento del nodo AV, puesto que, a pesar de su importancia en la correcta actividad del corazón, siguen existiendo muchas incógnitas relacionadas con los mecanismos de funcionamiento del mismo. En concreto, los mecanismos de propagación aurículo-ventriculares durante arritmias auriculares, como la fibrilación auricular (FA), sigue siendo una de las mayores incógnitas que se pretende esclarecer en la actualidad mediante la elaboración, uso y Modelización y analisis del efecto de las arrítmias auriculares sobre la respuesta ventricular estudio de modelos matemáticos como el que se presenta en este proyecto. No cabe duda, de que disponer de un conocimiento detallado de las propiedades de conducción del nodo AV, permitiría desarrollar nuevos tratamientos más efectivos que pudiesen ser utilizados para reducir los síntomas del flúter y la fibrilación auricular.Escrivá Muñoz, J. (2012). Modelización y analisis del efecto de las arrítmias auriculares sobre la respuesta ventricular. http://hdl.handle.net/10251/19030.Archivo delegad

Generation of realistic atrial to atrial interval series during atrial fibrillation

The aim of the this study is to describe a methodological architecture for the generation of realistic atrial to atrial activation intervals (AA) during atrial fibrillation (AF), which can be used to investigate the role of the fibrillatory process in the ventricular response during AF. In this study, a methodology for the generation of AA interval series with a desired probability density function and autocorrelation function is presented. The methodology was evaluated on 2000 AA interval series from 20 endocardial recordings. The results showed that synthetic AA series presented the same statistical characteristics as the real AA series, with a correlation higher than 0.94 (P < 0.01) for all measured statistical parameters. In addition, the role of each statistical characteristic of the AA interval series in the ventricular response during AF is examined using a mathematical model of the atrioventricular node. The statistical characteristics of the AA series influenced the position of more probable RR intervals and the shape of the RR histogram, demonstrating the importance of an accurate characterization and generation of AA interval series during AF. The use of the present methodology may help in understanding the role of the atrial fibrillatory process in the ventricular response during AF.This research was supported by Spanish Ministry of Education and Science under TEC2009-13939; the Universitat Politecnica de Valencia through its research initiative program; and the Spanish Society of Cardiology.Climent, AM.; Atienza, F.; Millet Roig, J.; Guillem Sánchez, MS. (2011). Generation of realistic atrial to atrial interval series during atrial fibrillation. Medical and Biological Engineering and Computing. 49(11):1261-1268. doi:10.1007/s11517-011-0823-2S126112684911Chen S, Nie H, Ayers-Glassey B (2008) Lognormal sum approximation with a variant of type IV Pearson distribution. 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