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Ensuring Access to Safe and Nutritious Food for All Through the Transformation of Food Systems
Richness of dynamics and global bifurcations in systems with a homoclinic figure-eight
We consider 2D flows with a homoclinic figure-eight to a dissipative saddle. We study the rich dynamics that such a system exhibits under a periodic forcing. First, we derive the bifurcation diagram using topological techniques. In particular, there is a homoclinic zone in the parameter space with a non-smooth boundary. We provide a complete explanation of this phenomenon relating it to primary quadratic homoclinic tangency curves which end up at some cubic tangency (cusp) points. We also describe the possible attractors that exist (and may coexist) in the system. A main goal of this work is to show how the previous qualitative description can be complemented with quantitative global information. To this end, we introduce a return map model which can be seen as the simplest one which is 'universal' in some sense. We carry out several numerical experiments on the model, to check that all the objects predicted to exist by the theory are found in the model, and also to investigate new properties of the system
Anuário científico da Escola Superior de Tecnologia da Saúde de Lisboa - 2021
É com grande prazer que apresentamos a mais recente edição (a 11.ª) do Anuário Científico da Escola Superior de Tecnologia da Saúde de Lisboa. Como instituição de ensino superior, temos o compromisso de promover e incentivar a pesquisa científica em todas as áreas do conhecimento que contemplam a nossa missão. Esta publicação tem como objetivo divulgar toda a produção científica desenvolvida pelos Professores, Investigadores, Estudantes e Pessoal não Docente da ESTeSL durante 2021. Este Anuário é, assim, o reflexo do trabalho árduo e dedicado da nossa comunidade, que se empenhou na produção de conteúdo científico de elevada qualidade e partilhada com a Sociedade na forma de livros, capítulos de livros, artigos publicados em revistas nacionais e internacionais, resumos de comunicações orais e pósteres, bem como resultado dos trabalhos de 1º e 2º ciclo. Com isto, o conteúdo desta publicação abrange uma ampla variedade de tópicos, desde temas mais fundamentais até estudos de aplicação prática em contextos específicos de Saúde, refletindo desta forma a pluralidade e diversidade de áreas que definem, e tornam única, a ESTeSL. Acreditamos que a investigação e pesquisa científica é um eixo fundamental para o desenvolvimento da sociedade e é por isso que incentivamos os nossos estudantes a envolverem-se em atividades de pesquisa e prática baseada na evidência desde o início dos seus estudos na ESTeSL. Esta publicação é um exemplo do sucesso desses esforços, sendo a maior de sempre, o que faz com que estejamos muito orgulhosos em partilhar os resultados e descobertas dos nossos investigadores com a comunidade científica e o público em geral. Esperamos que este Anuário inspire e motive outros estudantes, profissionais de saúde, professores e outros colaboradores a continuarem a explorar novas ideias e contribuir para o avanço da ciência e da tecnologia no corpo de conhecimento próprio das áreas que compõe a ESTeSL. Agradecemos a todos os envolvidos na produção deste anuário e desejamos uma leitura inspiradora e agradável.info:eu-repo/semantics/publishedVersio
A study of uncertainty quantification in overparametrized high-dimensional models
Uncertainty quantification is a central challenge in reliable and trustworthy
machine learning. Naive measures such as last-layer scores are well-known to
yield overconfident estimates in the context of overparametrized neural
networks. Several methods, ranging from temperature scaling to different
Bayesian treatments of neural networks, have been proposed to mitigate
overconfidence, most often supported by the numerical observation that they
yield better calibrated uncertainty measures. In this work, we provide a sharp
comparison between popular uncertainty measures for binary classification in a
mathematically tractable model for overparametrized neural networks: the random
features model. We discuss a trade-off between classification accuracy and
calibration, unveiling a double descent like behavior in the calibration curve
of optimally regularized estimators as a function of overparametrization. This
is in contrast with the empirical Bayes method, which we show to be well
calibrated in our setting despite the higher generalization error and
overparametrization
Estudo da remodelagem reversa miocárdica através da análise proteómica do miocárdio e do líquido pericárdico
Valve replacement remains as the standard therapeutic option for aortic
stenosis patients, aiming at abolishing pressure overload and triggering
myocardial reverse remodeling. However, despite the instant hemodynamic
benefit, not all patients show complete regression of myocardial hypertrophy,
being at higher risk for adverse outcomes, such as heart failure. The current
comprehension of the biological mechanisms underlying an incomplete reverse
remodeling is far from complete. Furthermore, definitive prognostic tools and
ancillary therapies to improve the outcome of the patients undergoing valve
replacement are missing. To help abridge these gaps, a combined myocardial
(phospho)proteomics and pericardial fluid proteomics approach was followed,
taking advantage of human biopsies and pericardial fluid collected during
surgery and whose origin anticipated a wealth of molecular information
contained therein.
From over 1800 and 750 proteins identified, respectively, in the myocardium
and in the pericardial fluid of aortic stenosis patients, a total of 90 dysregulated
proteins were detected. Gene annotation and pathway enrichment analyses,
together with discriminant analysis, are compatible with a scenario of increased
pro-hypertrophic gene expression and protein synthesis, defective ubiquitinproteasome system activity, proclivity to cell death (potentially fed by
complement activity and other extrinsic factors, such as death receptor
activators), acute-phase response, immune system activation and fibrosis.
Specific validation of some targets through immunoblot techniques and
correlation with clinical data pointed to complement C3 β chain, Muscle Ring
Finger protein 1 (MuRF1) and the dual-specificity Tyr-phosphorylation
regulated kinase 1A (DYRK1A) as potential markers of an incomplete
response. In addition, kinase prediction from phosphoproteome data suggests
that the modulation of casein kinase 2, the family of IκB kinases, glycogen
synthase kinase 3 and DYRK1A may help improve the outcome of patients
undergoing valve replacement. Particularly, functional studies with DYRK1A+/-
cardiomyocytes show that this kinase may be an important target to treat
cardiac dysfunction, provided that mutant cells presented a different response
to stretch and reduced ability to develop force (active tension).
This study opens many avenues in post-aortic valve replacement reverse
remodeling research. In the future, gain-of-function and/or loss-of-function
studies with isolated cardiomyocytes or with animal models of aortic bandingdebanding will help disclose the efficacy of targeting the surrogate therapeutic
targets. Besides, clinical studies in larger cohorts will bring definitive proof of
complement C3, MuRF1 and DYRK1A prognostic value.A substituição da válvula aórtica continua a ser a opção terapêutica de
referência para doentes com estenose aórtica e visa a eliminação da
sobrecarga de pressão, desencadeando a remodelagem reversa miocárdica.
Contudo, apesar do benefício hemodinâmico imediato, nem todos os pacientes
apresentam regressão completa da hipertrofia do miocárdio, ficando com maior
risco de eventos adversos, como a insuficiência cardíaca. Atualmente, os
mecanismos biológicos subjacentes a uma remodelagem reversa incompleta
ainda não são claros. Além disso, não dispomos de ferramentas de
prognóstico definitivos nem de terapias auxiliares para melhorar a condição
dos pacientes indicados para substituição da válvula. Para ajudar a resolver
estas lacunas, uma abordagem combinada de (fosfo)proteómica e proteómica
para a caracterização, respetivamente, do miocárdio e do líquido pericárdico
foi seguida, tomando partido de biópsias e líquidos pericárdicos recolhidos em
ambiente cirúrgico.
Das mais de 1800 e 750 proteínas identificadas, respetivamente, no miocárdio
e no líquido pericárdico dos pacientes com estenose aórtica, um total de 90
proteínas desreguladas foram detetadas. As análises de anotação de genes,
de enriquecimento de vias celulares e discriminativa corroboram um cenário de
aumento da expressão de genes pro-hipertróficos e de síntese proteica, um
sistema ubiquitina-proteassoma ineficiente, uma tendência para morte celular
(potencialmente acelerada pela atividade do complemento e por outros fatores
extrínsecos que ativam death receptors), com ativação da resposta de fase
aguda e do sistema imune, assim como da fibrose.
A validação de alguns alvos específicos através de immunoblot e correlação
com dados clínicos apontou para a cadeia β do complemento C3, a Muscle
Ring Finger protein 1 (MuRF1) e a dual-specificity Tyr-phosphoylation
regulated kinase 1A (DYRK1A) como potenciais marcadores de uma resposta
incompleta. Por outro lado, a predição de cinases a partir do fosfoproteoma,
sugere que a modulação da caseína cinase 2, a família de cinases do IκB, a
glicogénio sintase cinase 3 e da DYRK1A pode ajudar a melhorar a condição
dos pacientes indicados para intervenção. Em particular, a avaliação funcional
de cardiomiócitos DYRK1A+/- mostraram que esta cinase pode ser um alvo
importante para tratar a disfunção cardíaca, uma vez que os miócitos mutantes
responderam de forma diferente ao estiramento e mostraram uma menor
capacidade para desenvolver força (tensão ativa).
Este estudo levanta várias hipóteses na investigação da remodelagem reversa.
No futuro, estudos de ganho e/ou perda de função realizados em
cardiomiócitos isolados ou em modelos animais de banding-debanding da
aorta ajudarão a testar a eficácia de modular os potenciais alvos terapêuticos
encontrados. Além disso, estudos clínicos em coortes de maior dimensão
trarão conclusões definitivas quanto ao valor de prognóstico do complemento
C3, MuRF1 e DYRK1A.Programa Doutoral em Biomedicin
Annals [...].
Pedometrics: innovation in tropics; Legacy data: how turn it useful?; Advances in soil sensing; Pedometric guidelines to systematic soil surveys.Evento online. Coordenado por: Waldir de Carvalho Junior, Helena Saraiva Koenow Pinheiro, Ricardo Simão Diniz Dalmolin
Vortex properties in the extended supersolid phase of dipolar Bose-Einstein condensates.
We study the properties of singly quantized linear vortices in the supersolid phase of a dipolar Bose-Einstein condensate at zero-temperature modeling 164Dy atoms. The system is extended in the x−y plane and confined by a harmonic trap in the polarization direction z. Our study is based on a generalized Gross-Pitaevskii equation. We characterize the ground state of the system in terms of spatial order and superfluid fraction and compare the properties of a single vortex and of a vortex dipole in the superfluid phase (SFP) and in the supersolid phase (SSP). At variance with a vortex in the SFP, which is free to move in the superfluid, a vortex in the SSP is localized at the interstitial sites and does not move freely. We have computed the energy barrier for motion from an equilibrium site to another. The fact that the vortex is submitted to a periodic potential has a dramatic effect on the dynamics of a vortex dipole made of two counter-rotating parallel vortices; instead of rigidly translating as in the SFP, the vortex and antivortex approach each other by a series of jumps from one site to another until they annihilate in a very short time and their energy is transferred to bulk excitations
Interference mitigation in LiFi networks
Due to the increasing demand for wireless data, the radio frequency (RF) spectrum has
become a very limited resource. Alternative approaches are under investigation to support
the future growth in data traffic and next-generation high-speed wireless communication
systems. Techniques such as massive multiple-input multiple-output (MIMO), millimeter
wave (mmWave) communications and light-fidelity (LiFi) are being explored. Among
these technologies, LiFi is a novel bi-directional, high-speed and fully networked wireless
communication technology. However, inter-cell interference (ICI) can significantly restrict the
system performance of LiFi attocell networks. This thesis focuses on interference mitigation
in LiFi attocell networks.
The angle diversity receiver (ADR) is one solution to address the issue of ICI as well as
frequency reuse in LiFi attocell networks. With the property of high concentration gain and
narrow field of view (FOV), the ADR is very beneficial for interference mitigation. However,
the optimum structure of the ADR has not been investigated. This motivates us to propose the
optimum structures for the ADRs in order to fully exploit the performance gain. The impact
of random device orientation and diffuse link signal propagation are taken into consideration.
The performance comparison between the select best combining (SBC) and maximum ratio
combining (MRC) is carried out under different noise levels. In addition, the double source
(DS) system, where each LiFi access point (AP) consists of two sources transmitting the same
information signals but with opposite polarity, is proven to outperform the single source (SS)
system under certain conditions.
Then, to overcome issues around ICI, random device orientation and link blockage, hybrid
LiFi/WiFi networks (HLWNs) are considered. In this thesis, dynamic load balancing (LB)
considering handover in HLWNs is studied. The orientation-based random waypoint (ORWP)
mobility model is considered to provide a more realistic framework to evaluate the performance
of HLWNs. Based on the low-pass filtering effect of the LiFi channel, we firstly propose
an orthogonal frequency division multiple access (OFDMA)-based resource allocation (RA)
method in LiFi systems. Also, an enhanced evolutionary game theory (EGT)-based LB scheme
with handover in HLWNs is proposed.
Finally, due to the characteristic of high directivity and narrow beams, a vertical-cavity
surface-emitting laser (VCSEL) array transmission system has been proposed to mitigate
ICI. In order to support mobile users, two beam activation methods are proposed. The
beam activation based on the corner-cube retroreflector (CCR) can achieve low power
consumption and almost-zero delay, allowing real-time beam activation for high-speed users.
The mechanism based on the omnidirectional transmitter (ODTx) is suitable for low-speed
users and very robust to random orientation
Growth trends and site productivity in boreal forests under management and environmental change: insights from long-term surveys and experiments in Sweden
Under a changing climate, current tree and stand growth information is indispensable to the carbon sink strength of boreal forests. Important questions regarding tree growth are to what extent have management and environmental change influenced it, and how it might respond in the future. In this thesis, results from five studies (Papers I-V) covering growth trends, site productivity, heterogeneity in managed forests and potentials for carbon storage in forests and harvested wood products via differing management strategies are presented. The studies were based on observations from national forest inventories and long-term experiments in Sweden. The annual height growth of Scots pine (Pinus sylvestris) and Norway spruce (Picea abies) had increased, especially after the millennium shift, while the basal area growth remains stable during the last 40 years (Papers I-II). A positive response on height growth with increasing temperature was observed. The results generally imply a changing growing condition and stand composition. In Paper III, yield capacity of conifers was analysed and compared with existing functions. The results showed that there is a bias in site productivity estimates and the new functions give better prediction of the yield capacity in Sweden. In Paper IV, the variability in stand composition was modelled as indices of heterogeneity to calibrate the relationship between basal area and leaf area index in managed stands of Norway spruce and Scots pine. The results obtained show that the stand structural heterogeneity effects here are of such a magnitude that they cannot be neglected in the implementation of hybrid growth models, especially those based on light interception and light-use efficiency. In the long-term, the net climate benefits in Swedish forests may be maximized through active forest management with high harvest levels and efficient product utilization, compared to increasing carbon storage in standing forests through land set-asides for nature conservation (Paper V). In conclusion, this thesis offers support for the development of evidence-based policy recommendations for site-adapted and sustainable management of Swedish forests in a changing climate
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