Role of High-Mobility Group Box-1 in Liver Pathogenesis

High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location. While intracellular HMGB1 is important for DNA structure maintenance, gene expression, and autophagy induction, extracellular HMGB1 acts as a damage-associated molecular pattern (DAMP) molecule to alert the host of damage by triggering immune responses. The biological function of HMGB1 is mediated by multiple receptors, including the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs), which are expressed in different hepatic cells. Activation of HMGB1 and downstream signaling pathways are contributing factors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and drug-induced liver injury (DILI), each of which involves sterile inflammation, liver fibrosis, ductular reaction, and hepatic tumorigenesis. In this review, we will discuss the critical role of HMGB1 in these pathogenic contexts and propose HMGB1 as a bona fide and targetable DAMP in the setting of common liver diseases

The J-Box Problem

The study group was presented with the problem of determining the behaviour of a web of wet cellulose fibres - called a tow - as it passes through part of the manufacturing process. The name of the problem derives from the fact that on its passage down the production line the tow passes through a J-shaped box, whose purpose is to provide a buffer where the tow is stored long enough and hot enough for certain chemical reactions to take place, mainly concerned with giving the right quality to the fibre surface. (The production line in fact involves two J-boxes, one containing wet tow, the other dry, and we are here entirely concerned with the first of these, the wet J-box.) Three aspects of the tow behaviour were proposed for investigation: 1. What is the mechanical behaviour of the tow within the J-box ? Specifically, how do the time spent within the J-box and the shape of the tow outlet column depend on the J- box geometry, tow density and compressibility, flow rate, friction coefficients etc. 2. What is the temperature history, and hence the chemical history, of the tow within the J-box? 3. Why do dislocations and loops occur within the tow? We first give typical parameters and other details of the process, and then further details of these three questions

Efficient Black-Box Identity Testing for Free Group Algebras

Hrubes and Wigderson [Pavel Hrubes and Avi Wigderson, 2014] initiated the study of noncommutative arithmetic circuits with division computing a noncommutative rational function in the free skew field, and raised the question of rational identity testing. For noncommutative formulas with inverses the problem can be solved in deterministic polynomial time in the white-box model [Ankit Garg et al., 2016; Ivanyos et al., 2018]. It can be solved in randomized polynomial time in the black-box model [Harm Derksen and Visu Makam, 2017], where the running time is polynomial in the size of the formula. The complexity of identity testing of noncommutative rational functions, in general, remains open for noncommutative circuits with inverses. We solve the problem for a natural special case. We consider expressions in the free group algebra F(X,X^{-1}) where X={x_1, x_2, ..., x_n}. Our main results are the following. 1) Given a degree d expression f in F(X,X^{-1}) as a black-box, we obtain a randomized poly(n,d) algorithm to check whether f is an identically zero expression or not. The technical contribution is an Amitsur-Levitzki type theorem [A. S. Amitsur and J. Levitzki, 1950] for F(X, X^{-1}). This also yields a deterministic identity testing algorithm (and even an expression reconstruction algorithm) that is polynomial time in the sparsity of the input expression. 2) Given an expression f in F(X,X^{-1}) of degree D and sparsity s, as black-box, we can check whether f is identically zero or not in randomized poly(n,log s, log D) time. This yields a randomized polynomial-time algorithm when D and s are exponential in n

Sound radiation characteristics of a box-type structure

The finite element and boundary element methods are employed in this study to investigate the sound radiation characteristics of a box-type structure. It has been shown [T.R. Lin, J. Pan, Vibration characteristics of a box-type structure, Journal of Vibration and Acoustics, Transactions of ASME 131 (2009) 031004-1–031004-9] that modes of natural vibration of a box-type structure can be classified into six groups according to the symmetry properties of the three panel pairs forming the box. In this paper, we demonstrate that such properties also reveal information about sound radiation effectiveness of each group of modes. The changes of radiation efficiencies and directivity patterns with the wavenumber ratio (the ratio between the acoustic and the plate bending wavenumbers) are examined for typical modes from each group. Similar characteristics of modal radiation efficiencies between a box structure and a corresponding simply supported panel are observed. The change of sound radiation patterns as a function of the wavenumber ratio is also illustrated. It is found that the sound radiation directivity of each box mode can be correlated to that of elementary sound sources (monopole, dipole, etc.) at frequencies well below the critical frequency of the plates of the box. The sound radiation pattern on the box surface also closely related to the vibration amplitude distribution of the box structure at frequencies above the critical frequency. In the medium frequency range, the radiated sound field is dominated by the edge vibration pattern of the box. The radiation efficiency of all box modes reaches a peak at frequencies above the critical frequency, and gradually approaches unity at higher frequencies

Z-D Brane Box Models and Non-Chiral Dihedral Quivers

Generalising ideas of an earlier work \cite{Bo-Han}, we address the problem of constructing Brane Box Models of what we call the Z-D Type from a new point of view, so as to establish the complete correspondence between these brane setups and orbifold singularities of the non-Abelian G generated by Z_k and D_d under certain group-theoretic constraints to which we refer as the BBM conditions. Moreover, we present a new class of ${\cal N}=1$ quiver theories of the ordinary dihedral group d_k as well as the ordinary exceptionals E_{6,7,8} which have non-chiral matter content and discuss issues related to brane setups thereof