The gastric acid pocket is attenuated in H. pylori infected subjects

Objective Gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in Helicobacter pylori positive and negative volunteers in a Western population. Design We studied 31 H. pylori positive and 28 H. pylori negative volunteers, matched for age, gender and body mass index. Jumbo biopsies were taken at 11 predetermined locations from the gastro-oesophageal junction and stomach. Combined high-resolution pH metry (12 sensors) and manometry (36 sensors) was performed for 20 min fasted and 90 min postprandially. The squamocolumnar junction was marked with radio-opaque clips and visualised radiologically. Biopsies were scored for inflammation and density of parietal, chief and G cells immunohistochemically. Results Under fasting conditions, the H. pylori positives had less intragastric acidity compared with negatives at all sensors >1.1 cm distal to the peak lower oesophageal sphincter (LES) pressure (p<0.01). Postprandially, intragastric acidity was less in H. pylori positives at sensors 2.2, 3.3 and 4.4 cm distal to the peak LES pressure (p<0.05), but there were no significant differences in more distal sensors. The postprandial acid pocket was thus attenuated in H. pylori positives. The H. pylori positives had a lower density of parietal and chief cells compared with H. pylori negatives in 10 of the 11 gastric locations (p<0.05). 17/31 of the H. pylori positives were CagA-seropositive and showed a more marked reduction in intragastric acidity and increased mucosal inflammation. Conclusions In population volunteers, H. pylori positives have reduced intragastric acidity which most markedly affects the postprandial acid pocket

Inclusive Decays of Heavy Quarkonium to Light Particles

We derive the imaginary part of the potential NRQCD Hamiltonian up to order 1/m^4, when the typical momentum transfer between the heavy quarks is of the order of Lambda_{QCD} or greater, and the binding energy E much smaller than Lambda_{QCD}. We use this result to calculate the inclusive decay widths into light hadrons, photons and lepton pairs, up to O(mv^3 x (Lambda_{QCD}^2/m^2,E/m)) and O(mv^5) times a short-distance coefficient, for S- and P-wave heavy quarkonium states, respectively. We achieve a large reduction in the number of unknown non-perturbative parameters and, therefore, we obtain new model-independent QCD predictions. All the NRQCD matrix elements relevant to that order are expressed in terms of the wave functions at the origin and six universal non-perturbative parameters. The wave-function dependence factorizes and drops out in the ratio of hadronic and electromagnetic decay widths. The universal non-perturbative parameters are expressed in terms of gluonic field-strength correlators, which may be fixed by experimental data or, alternatively, by lattice simulations. Our expressions are expected to hold for most of the charmonium and bottomonium states below threshold. The calculations and methodology are explained in detail so that the evaluation of higher order NRQCD matrix elements in this framework should be straightforward. An example is provided.Comment: 61 pages, 9 figures. Minor change

Poincare' invariance and the heavy-quark potential

We derive and discuss the constraints induced by Poincare' invariance on the form of the heavy-quark potential up to order 1/m^2. We present two derivations: one uses general arguments directly based on the Poincare' algebra and the other follows from an explicit calculation on the expression of the potential in terms of Wilson loops. We confirm relations from the literature, but also clarify the origin of a long-standing false statement pointed out recently.Comment: 20 pages, 4 figure

Recurrence following anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction. a systematic review

BACKGROUND: Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. MATERIALS AND METHODS: A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients. RESULTS: The frequency of anastomotic leakage ranged from 7.2 to 11.2%. Patients affected by anastomotic leakage had a recurrence rate of 9-56%. CONCLUSION: Closer follow-up or even more aggressive oncological therapy should be considered for patients affected by anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction

Understanding the proton spin "puzzle" with a new "minimal" quark model

We investigate the spin structure of the nucleon in an extended Jaffe-Lipkin quark model. In addition to the conventional $3q$ structure, different $(3q)(Q\bar{Q})$ admixtures in the nucleon wavefunction are also taken into account. The contributions to the nucleon spin from various components of the nucleon wavefunction are discussed. The effect due to the Melosh-Wigner rotation is also studied. It is shown that the Jaffe-Lipkin term is only important when antiquarks are negatively polarized. We arrive at a new "minimal" quark model, which is close to the naive quark model, in order to understand the proton spin "puzzle".Comment: 19 latex pages, Published in Eur.Phys.J.

Simple unconventional geometric scenario of one-way quantum computation with superconducting qubits inside a cavity

We propose a simple unconventional geometric scenario to achieve a kind of nontrivial multi-qubit operations with superconducting charge qubits placed in a microwave cavity. The proposed quantum operations are insensitive not only to the thermal state of cavity mode but also to certain random operation errors, and thus may lead to high-fidelity quantum information processing. Executing the designated quantum operations, a class of highly entangled cluster states may be generated efficiently in the present scalable solid-state system, enabling one to achieve one-way quantum computation.Comment: Accepted version with minor amendments. To appear in Phys. Rev.

Agricultural Liberalization in the Doha Round.

The analysis of agricultural liberalization reveals very large potential gains for both developed and developing countries that will come especially from own-country liberalization as well as from inter-country trade, significant benefits that may be realized by the poorest developing countries, and limited benefits from existing preferential agricultural arrangements. An ideal program for agricultural liberalization in the Doha Round would involve substantial reductions in the high tariffs that exist in both developed and developing countries using the Swiss formula approach and limiting exceptions and special and differential treatment, elimination of agricultural export subsidies, and making meaningful reductions in domestic supports. The negotiations should not get hung up on issues of food security and the effects of higher prices for low-income consumers, and a special safeguard for agriculture is not recommended. It is imperative that agricultural liberalization should be combined with appropriate domestic policies and actions and international assistance, if needed, to help finance emergency food inventories and aid to disadvantaged groups.agriculture;Doha;WTO;