Climate change may have minor impact on zooplankton functional diversity in the Mediterranean Sea

Aim To assess the impact of climate change on the functional diversity of marine zooplankton communities. Location The Mediterranean Sea. Methods We used the functional traits and geographic distributions of 106 copepod species to estimate the zooplankton functional diversity of Mediterranean surface assemblages for the 1965–1994 and 2069–2098 periods. Multiple environmental niche models were trained at the global scale to project the species habitat suitability in the Mediterranean Sea and assess their sensitivity to climate change predicted by several scenarios. Simultaneously, the species traits were used to compute a functional dendrogram from which we identified seven functional groups and estimated functional diversity through Faith's index. We compared the measured functional diversity to the one originated from null models to test if changes in functional diversity were solely driven by changes in species richness. Results All but three of the 106 species presented range contractions of varying intensity. A relatively low decrease of species richness (−7.42 on average) is predicted for 97% of the basin, with higher losses in the eastern regions. Relative sensitivity to climate change is not clustered in functional space and does not significantly vary across the seven copepod functional groups defined. Changes in functional diversity follow the same pattern and are not different from those that can be expected from changes in richness alone. Main conclusions Climate change is not expected to alter copepod functional traits distribution in the Mediterranean Sea, as the most and the least sensitive species are functionally redundant. Such redundancy should buffer the loss of ecosystem functions in Mediterranean zooplankton assemblages induced by climate change. Because the most negatively impacted species are affiliated to temperate regimes and share Atlantic biogeographic origins, our results are in line with the hypothesis of increasingly more tropical Mediterranean communities

Changes in Functional Connectivity Associated with Treatment Gains in Aphasia

NIDCD/NIH (F31 NRSA grant 1F31DC011220-01A1); Boston University Sargent College (Dudley Allen Sargent Research Award

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure.

Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide. In erythrocytes, ceramide formation leads to exposure of the removal signal phosphatidylserine (PS), creating a potential link between SMase activity and anemia of inflammation. Therefore, we studied the effects of SMase on various pathophysiologically relevant parameters of erythrocyte homeostasis. Time-lapse confocal microscopy revealed a SMase-induced transition from the discoid to a spherical shape, followed by PS exposure, and finally loss of cytoplasmic content. Also, SMase treatment resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization, including microdomain formation. Furthermore, we observed increases in membrane fragility, vesiculation and invagination, and large protein clusters. These changes were associated with enhanced erythrocyte retention in a spleen-mimicking model. Erythrocyte storage under blood bank conditions and during physiological aging increased the sensitivity to SMase. A low SMase activity already induced morphological and structural changes, demonstrating the potential of SMase to disturb erythrocyte homeostasis. Our analyses provide a comprehensive picture in which ceramide-induced changes in membrane microdomain organization disrupt the membrane-cytoskeleton interaction and membrane integrity, leading to vesiculation, reduced deformability, and finally loss of erythrocyte content. Understanding these processes is highly relevant for understanding anemia during chronic inflammation, especially in critically ill patients receiving blood transfusions

Recent modifications of the functional and communicative characteristics of english modals

The article deals with the present-day trends in changes and modification of the functional and communicative features of the English modals. These changes are manifested mainly in three main directions which are determined by the changes in social attitudes

Functional Principal Component Analysis for Non-stationary Dynamic Time Series

Motivated by a highly dynamic hydrological high-frequency time series, we propose time-varying Functional Principal Component Analysis (FPCA) as a novel approach for the analysis of non-stationary Functional Time Series (FTS) in the frequency domain. Traditional FPCA does not take into account (i) the temporal dependence between the functional observations and (ii) the changes in the covariance/variability structure over time, which could result in inadequate dimension reduction. The novel time-varying FPCA proposed adapts to the changes in the auto-covariance structure and varies smoothly over frequency and time to allow investigation of whether and how the variability structure in an FTS changes over time. Based on the (smooth) time-varying dynamic FPCs, a bootstrap inference procedure is proposed to detect significant changes in the covariance structure over time. Although this time-varying dynamic FPCA can be applied to any dynamic FTS, it has been applied here to study the daily processes of partial pressure of CO2 in a small river catchment in Scotland

Master Functional And Proper Formalism For Quantum Gauge Field Theory

We develop a general field-covariant approach to quantum gauge theories. Extending the usual set of integrated fields and external sources to "proper" fields and sources, which include partners of the composite fields, we define the master functional Omega, which collects one-particle irreducible diagrams and upgrades the usual Gamma-functional in several respects. The functional Omega is determined from its classical limit applying the usual diagrammatic rules to the proper fields. Moreover, it behaves as a scalar under the most general perturbative field redefinitions, which can be expressed as linear transformations of the proper fields. We extend the Batalin-Vilkovisky formalism and the master equation. The master functional satisfies the extended master equation and behaves as a scalar under canonical transformations. The most general perturbative field redefinitions and changes of gauge-fixing can be encoded in proper canonical transformations, which are linear and do not mix integrated fields and external sources. Therefore, they can be applied as true changes of variables in the functional integral, instead of mere replacements of integrands. This property overcomes a major difficulty of the functional Gamma. Finally, the new approach allows us to prove the renormalizability of gauge theories in a general field-covariant setting. We generalize known cohomological theorems to the master functional and show that when there are no gauge anomalies all divergences can be subtracted by means of parameter redefinitions and proper canonical transformations.Comment: 32 pages; v2: minor changes and proof corrections, EPJ

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in underlying neural activity. An understanding of the mechanisms that link changes in neural activity to changes in blood flow is crucial for assessing the validity of this assumption, and for understanding the processes that can go wrong during disease states such as ischaemic stroke. Many studies have investigated the mechanisms of neurovascular regulation in arterioles but other evidence suggests that blood flow regulation can also occur in capillaries, because of the presence of contractile cells, pericytes, on the capillary wall. Here we review the evidence that pericytes can modulate capillary diameter in response to neuronal activity and assess the likely importance of neurovascular regulation at the capillary level for functional imaging experiments. We also discuss evidence suggesting that pericytes are particularly sensitive to damage during pathological insults such as ischaemia, Alzheimer’s disease and diabetic retinopathy, and consider the potential impact that pericyte dysfunction might have on the development of therapeutic interventions and on the interpretation of functional imaging data in these disorders