Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role. We therefore aimed to identify differentially methylated regions (DMRs) upon occupational exposures in never-smokers and investigated if these DMRs associated with gene expression levels. To determine the effects of occupational exposures independent of smoking, 903 never-smokers of the LifeLines cohort study were included. We performed three genome-wide methylation analyses (Illumina 450 K), one per occupational exposure being gases/fumes, mineral dust and biological dust, using robust linear regression adjusted for appropriate confounders. DMRs were identified using comb-p in Python. Results were validated in the Rotterdam Study (233 never-smokers) and methylation-expression associations were assessed using Biobank-based Integrative Omics Study data (n = 2802). Of the total 21 significant DMRs, 14 DMRs were associated with gases/fumes and 7 with mineral dust. Three of these DMRs were associated with both exposures (RPLP1 and LINC02169 (2x)) and 11 DMRs were located within transcript start sites of gene expression regulating genes. We replicated two DMRs with gases/fumes (VTRNA2-1 and GNAS) and one with mineral dust (CCDC144NL). In addition, nine gases/fumes DMRs and six mineral dust DMRs significantly associated with gene expression levels. Our data suggest that occupational exposures may induce differential methylation of gene expression regulating genes and thereby may induce adverse health effects. Given the millions of workers that are exposed daily to occupational exposures, further studies on this epigenetic mechanism and health outcomes are warranted

Apparatus for purging systems handling toxic, corrosive, noxious and other fluids Patent

Fluid transferring system design for purging toxic, corrosive, or noxious fluids and fumes from materials handling equipment for cleansing and accident preventio

Box-Cox symmetric distributions and applications to nutritional data

We introduce the Box-Cox symmetric class of distributions, which is useful for modeling positively skewed, possibly heavy-tailed, data. The new class of distributions includes the Box-Cox t, Box-Cox Cole-Gree, Box-Cox power exponential distributions, and the class of the log-symmetric distributions as special cases. It provides easy parameter interpretation, which makes it convenient for regression modeling purposes. Additionally, it provides enough flexibility to handle outliers. The usefulness of the Box-Cox symmetric models is illustrated in applications to nutritional data.Comment: 25 pages, 4 figure

The emerging of employment gap in the Malaysian construction industry

Employment of young people is a big issue in the Malaysian construction industry. This is a common phenomenon not only in Malaysia but affected most developed and developing countries around the world. Sufficient workers are needed to cater to the robustness of the construction sector and to sustain the productivity that will boost the development demand. However, young people had difficulties to find decent employment in this industry due to lack of experience and skills among young people and some employer are more likely to hire foreign workers. The aim of this study is to examine the emerging of skill gaps in the Malaysian construction industry. The methodology adapted for this study comprise of primary and secondary data collection. The primary data had been collected from the questionnaire surveys on the professional within the construction industry. The data then were analyzed using the percentage score and the diagram such as bar chart had been used to visualize the results from the analysis. While, secondary data collected through literature review to gather information and important views from previous studies. The findings reveal that the construction industry prefer more than 30 years old skilled workers. Eventhough, the jobs could be filled by young people, but somehow, some barriers such as high risk, low wages, hard work and availability of foreign workers had distracted the involvement of young people in the construction industry

Cables and fire hazards

Besides describing the experiments conducted to develop a nonflammable cable, this article discusses several considerations regarding other hazards which might result from cable fires, particularly the toxicity and opacity of the fumes emitted by the burning cable. In addition, this article examines the effects of using the Oxygen Index as a gauge of quality control during manufacture

Effects of soil variation between peat soil and mineral soil on fruit quality of pineapple (Ananas Comosus) cultivars: N36 and josapine

Consumption of pineapple is predicted to increase in the near future in which the demand for continuous supply of the fruit becomes of major interest. This research is focused on finding the influence of growth medium between peat soil and mineral soil to the weight and production of vitamin C and sugar contents of the pineapple fruits. Two cultivars were investigated: N36 and Josapine. The vitamin C is quantified by Iodate Titration and sugar content is analyzed by Digital Refractometer. The chemical soil properties were analyzed by using atomic absorption spectrophotometer at the Soil Analysis Section laboratory from Department Of Agriculture, Malaysia. All data were analyzed statistically through ANOVA by using SPSS. Results indicated that pineapple planted on peat soil produced heavier fruits than those in mineral soil. N36 pineapple reports no significant difference (p < 0.05) of the vitamin C content and the sweetness between different cultivation soil types. However, Josapine pineapples cultivated on mineral soil (FIMA Plantation) produce significantly 115% higher vitamin C content (19.243 ± 7.191 mg∙100g-1), and significantly 30% lower sugar content (5.403 ± 1.721% °Bx) than cultivated on peat soil (Peninsula Plantations). The finding of the soil type’s influence on the fruit quality production is beneficial for pineapple producers and researchers to broaden up the development of pineapple-based products in the long run. The promotion of pineapple nutritional contents is beneficial to increase consumers’ knowledge and awareness on the importance of pineapple consumption especially in Asian regions

An investigation on benefits and future expectation of Industrialised Building System (IBS) implementation in construction practices

Industrialised Building System (IBS) is well known in many developing countries due to the benefits that can be derived from its applications in construction projects. However, the low percentage of IBS usage may be due to lack of awareness and knowledge about IBS among many professionals. There may be factors that contribute to a lack of interest from the client towards IBS. The aim of this study is to improve the application of IBS particularly in private construction projects in Malaysia by determining the benefits and expectation on application of IBS in private construction projects. This study adopts a quantitative method using questionnaires that were sent to 35 construction firms as a sampling frame. Finally, the finding of this study hopefully could assist professional parties in construction industry in providing a better ground knowledge for improving decisions making to achieve the success of IBS construction projects implementation and also this study will achieved the project objectives in terms of predetermined objectives that are mostly within the time, specified budget and standard qualit

Workplace stress experienced by contractor in Malaysian construction industry

Work pressure can be experienced by any of the parties and organizations within various sectors. The work pressure issue also can be found in the construction industry, as the orientation and the nature of the job lead toward work pressure, such as organization factors, work demand factors, job roles and challenging work environment. Besides, previous studies have proven that uncontrollable of work pressure also led positively towards accident on a construction site. However, this issue had a lack of support and consensus among the parties itself. Therefore, this study is being carried out to explore the issue work stress in the Malaysian construction industry. The aim of this study is to identify the major contributor and measure work stress level in the Malaysian construction industry. The study was conducted within 78 individuals that involved from G7 class of contractors in Malacca with 74% rate of respond. This research is statistically descriptive orientation and questionnaire is being used as a research instrument. Data were analyzed by using the Statistical Package for the Social Sciences 20.0 software. Based on the results, it showed that work demand is the main factors contributing to the high-pressure jobs. Level of work stress experienced by the respondents is high, but they still have a good job in terms of achievements and satisfaction. Therefore, based on the results, all parties; DOSH, CIDB, contractors and others should take this issue seriously. The parties also need to put effort to handle the issue as its consider as an alternative to reduce the number of accidents in construction sites as well as improving performance of the industry

A review of agricultural waste activated carbon and effect on adsorption parameters

Activated carbon is widely used in industrial wastewater treatment operation because of the effectiveness in removing the dye. As the conventional activated carbon on market nowadays is expensive, lots of research was done on agricultural materials to replace the activated carbon. Sugarcane bagasse is listed as one of the agricultural material alternatives. This review compiles the characterisation of sugarcane bagasse and several agricultural wastes-based activated carbon including proximate analysis, ultimate analysis, and activated carbon surface characteristic used to remove dye in textile wastewater. Nevertheless, the adsorption parameters are the main focus as it affecting the removal of dye. The expansion review regarding activated carbon performance implies that dye removal efficiency depends on the amount of adsorbent dosage, contact time, pH solution, dye concentration applied during the adsorption process. This review shows the need of thoughtful information on adsorption parameters with an expanded list of various types of agricultural-based activated carbon and various dye removal