56 research outputs found
Endoscopic imaging of quantum gases through a fiber bundle
We use a coherent fiber bundle to demonstrate the endoscopic absorption
imaging of quantum gases. We show that the fiber bundle introduces spurious
noise in the picture mainly due to the strong core-to-core coupling. By direct
comparison with free-space pictures, we observe that there is a maximum column
density that can be reliably measured using our fiber bundle, and we derive a
simple criterion to estimate it. We demonstrate that taking care of not
exceeding such maximum, we can retrieve exact quantitative information about
the atomic system, making this technique appealing for systems requiring
isolation form the environment
Beyond backscattering: Optical neuroimaging by BRAD
Optical coherence tomography (OCT) is a powerful technology for rapid
volumetric imaging in biomedicine. The bright field imaging approach of
conventional OCT systems is based on the detection of directly backscattered
light, thereby waiving the wealth of information contained in the angular
scattering distribution. Here we demonstrate that the unique features of
few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging
for OCT. As backscattered light is picked up by the different modes of a FMF
depending upon the angular scattering pattern, we obtain access to the
directional scattering signatures of different tissues by decoupling
illumination and detection paths. We exploit the distinct modal propagation
properties of the FMF in concert with the long coherence lengths provided by
modern wavelength-swept lasers to achieve multiplexing of the different modal
responses into a combined OCT tomogram. We demonstrate BRAD sensing for
distinguishing differently sized microparticles and showcase the performance of
BRAD-OCT imaging with enhanced contrast for ex vivo tumorous tissue in
glioblastoma and neuritic plaques in Alzheimer's disease
Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response.National Institutes of Health (U.S.) (R44EY022864-01)National Institutes of Health (U.S.) (R01-CA75289-17)National Institutes of Health (U.S.) (R44-CA101067-06)National Institutes of Health (U.S.) ( R01-EY011289-27)National Institutes of Health (U.S.) (R01-HL095717-04)National Institutes of Health (U.S.) (R01-NS057476-05)United States. Air Force Office of Scientific Research (FA9550-10-1-0063)United States. Air Force Office of Scientific Research. Medical Free Electron Laser Program (FA9550-10-1-0551)German Research Foundation (DFG-GSC80-SAOT)German Research Foundation (DFG-HO-1791/11-1)Center for Integration of Medicine and Innovative Technolog
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