13,607 research outputs found

    Efficient simulations of ionized ISM emission lines: A detailed comparison between the FIRE high-redshift suite and observations

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    The Atacama Large Millimeter/Submillimeter Array (ALMA) in the sub-millimeter and the James Webb Space Telescope (JWST) in the infrared have achieved robust spectroscopic detections of emission lines from the interstellar medium (ISM) in some of the first galaxies. These unprecedented measurements provide valuable information regarding the ISM properties, stellar populations, galaxy morphologies, and kinematics in these high-redshift galaxies and, in principle, offer powerful tests of state-of-the-art galaxy formation models, as implemented in hydrodynamical simulations. To facilitate direct comparisons between simulations and observations, we develop a fast post-processing pipeline for predicting the line emission from the HII regions around simulated star particles, accounting for spatial variations in the surrounding gas density, metallicity, temperature, and incident radiation spectrum. Our ISM line emission model currently captures Hα\alpha, Hβ\beta, and all of the [OIII] and [OII] lines targeted by ALMA and the JWST at z>6z>6. We illustrate the power of this approach by applying our line emission model to the publicly available FIRE high-zz simulation suite and perform a detailed comparison with current observations. We show that the FIRE mass--metallicity relation is in 1σ1\sigma agreement with ALMA/JWST measurements after accounting for the inhomogeneities in ISM properties. We also quantitatively validate the one-zone model description, which is widely used for interpreting [OIII] and Hβ\beta line luminosity measurements. This model is publicly available and can be implemented on top of a broad range of galaxy formation simulations for comparison with JWST and ALMA measurements.Comment: 15 pages, 13 figure

    Atypical developmental trajectories of white matter microstructure in prenatal alcohol exposure: Preliminary evidence from neurite orientation dispersion and density imaging

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    IntroductionFetal alcohol spectrum disorder (FASD), a life-long condition resulting from prenatal alcohol exposure (PAE), is associated with structural brain anomalies and neurobehavioral differences. Evidence from longitudinal neuroimaging suggest trajectories of white matter microstructure maturation are atypical in PAE. We aimed to further characterize longitudinal trajectories of developmental white matter microstructure change in children and adolescents with PAE compared to typically-developing Controls using diffusion-weighted Neurite Orientation Dispersion and Density Imaging (NODDI).Materials and methodsParticipants: Youth with PAE (n = 34) and typically-developing Controls (n = 31) ages 8–17 years at enrollment. Participants underwent formal evaluation of growth and facial dysmorphology. Participants also completed two study visits (17 months apart on average), both of which involved cognitive testing and an MRI scan (data collected on a Siemens Prisma 3 T scanner). Age-related changes in the orientation dispersion index (ODI) and the neurite density index (NDI) were examined across five corpus callosum (CC) regions defined by tractography.ResultsWhile linear trajectories suggested similar overall microstructural integrity in PAE and Controls, analyses of symmetrized percent change (SPC) indicated group differences in the timing and magnitude of age-related increases in ODI (indexing the bending and fanning of axons) in the central region of the CC, with PAE participants demonstrating atypically steep increases in dispersion with age compared to Controls. Participants with PAE also demonstrated greater increases in ODI in the mid posterior CC (trend-level group difference). In addition, SPC in ODI and NDI was differentially correlated with executive function performance for PAE participants and Controls, suggesting an atypical relationship between white matter microstructure maturation and cognitive function in PAE.DiscussionPreliminary findings suggest subtle atypicality in the timing and magnitude of age-related white matter microstructure maturation in PAE compared to typically-developing Controls. These findings add to the existing literature on neurodevelopmental trajectories in PAE and suggest that advanced biophysical diffusion modeling (NODDI) may be sensitive to biologically-meaningful microstructural changes in the CC that are disrupted by PAE. Findings of atypical brain maturation-behavior relationships in PAE highlight the need for further study. Further longitudinal research aimed at characterizing white matter neurodevelopmental trajectories in PAE will be important

    Computer simulations of end-tapering anchorages of EBR FRP-strengthened prestressed concrete slabs at service conditions

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    This article examines numerically the behavior of prestressed reinforced concrete slabs strengthened with externally bonded reinforcement (EBR) consisting of fiber-reinforced polymer (FRP) sheets. The non-linear finite element (FE) program Abaqus® is used to model EBR FRP-strengthened prestressed concrete slabs tested previously in four-point bending. After the calibration of the computational models, a parametric study is then conducted to assess the influence of the FRP axial stiffness (thickness and modulus of elasticity) on the interfacial normal and shear stresses. The numerical analysis results show that increasing the thickness or the elastic modulus of the FRP strengthening affects the efficiency of the FRP bonding and makes it susceptible to earlier debonding failures. A tapering technique is proposed in wet lay-up applications since multiple FRP layers are often required. It is shown that by gradually decreasing the thickness of the FRP strengthening, the concentration of stress along the plate end can be reduced, and thus, the overall strengthening performance is maximized. The tapering is successful in reducing the bond stress concentrations by up to 15%, which can be sufficient to prevent concrete rip-off and peel-off debonding failure modes. This article contributes towards a better understanding of the debonding phenomena in FRP-strengthened elements in flexure and towards the development of more efficient computational tools to analyze such structures

    Innovative finance mechanisms to protect water resources in the Xin’an River Basin

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    This brief shows how innovative financing can help cut agricultural pollution in the People's Republic of China’s Xin'an River Basin by plugging funding gaps for nature-based solutions that also mitigate against climate change. It highlights the importance of the basin that supplies drinking water to 10 million people and explains how insufficient financing is limiting the effectiveness of existing ecological compensation schemes. Offering policy recommendations to incentivize environmental protections, the brief details how two ADB-backed funds can be scaled up to support efforts by farmers and small businesses to make the watershed green, sustainable, and inclusive

    Redefining quality interpersonal communication and communication activities in marriage from divorcees’ perspectives

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    Quality interpersonal communication is essential in the development and maintenance of any relationship, including marriage. As society adapts to new avenues of communication, married couples often underestimate the relevance of interpersonal communication in their relationship due to their lack of understanding of quality interpersonal communication. Therefore, this study investigated the conceptualisation of quality interpersonal communication through the lens of Relational Dialectic Theory and communication activities in marriage from the perspectives of divorcees. This study also explored the antecedents of poor-quality interpersonal communication and its repercussions on married couples. The present study also extended Knapp’s Relational Development Model by incorporating communication technology as a medium of communication. In-depth interviews were conducted on 20 divorcees from different states in Malaysia, chosen through a purposive sampling technique. The gathered data was then evaluated and combined in a thematic data analysis using the NVivo 12 software. This study discovers that the definitions of quality interpersonal communication are divided into seven (7) categories, with communication skills, intimacy, and characters identified as the top three significant traits. Results of this study also indicate that spouses use various medium of communication based on their circumstances but prefer face-to-face communication. However, communication occurrences between spouses are low and mostly negative, with the majority of them mainly involving households and children. The other antecedents of poor-quality interpersonal communication are communication skills, attitudes, third-party involvement, and emotional condition. The current study concludes that emotional condition is one of the protuberant effects of poor-quality interpersonal communication. All in all, the current study provides a new paradigm in Knapp’s Relational Development Model through the incorporation of the effects of poor-quality interpersonal communication into the deterioration stages of the model

    Open Set Classification of GAN-based Image Manipulations via a ViT-based Hybrid Architecture

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    Classification of AI-manipulated content is receiving great attention, for distinguishing different types of manipulations. Most of the methods developed so far fail in the open-set scenario, that is when the algorithm used for the manipulation is not represented by the training set. In this paper, we focus on the classification of synthetic face generation and manipulation in open-set scenarios, and propose a method for classification with a rejection option. The proposed method combines the use of Vision Transformers (ViT) with a hybrid approach for simultaneous classification and localization. Feature map correlation is exploited by the ViT module, while a localization branch is employed as an attention mechanism to force the model to learn per-class discriminative features associated with the forgery when the manipulation is performed locally in the image. Rejection is performed by considering several strategies and analyzing the model output layers. The effectiveness of the proposed method is assessed for the task of classification of facial attribute editing and GAN attribution

    Examples of works to practice staccato technique in clarinet instrument

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    Klarnetin staccato tekniğini güçlendirme aşamaları eser çalışmalarıyla uygulanmıştır. Staccato geçişlerini hızlandıracak ritim ve nüans çalışmalarına yer verilmiştir. Çalışmanın en önemli amacı sadece staccato çalışması değil parmak-dilin eş zamanlı uyumunun hassasiyeti üzerinde de durulmasıdır. Staccato çalışmalarını daha verimli hale getirmek için eser çalışmasının içinde etüt çalışmasına da yer verilmiştir. Çalışmaların üzerinde titizlikle durulması staccato çalışmasının ilham verici etkisi ile müzikal kimliğe yeni bir boyut kazandırmıştır. Sekiz özgün eser çalışmasının her aşaması anlatılmıştır. Her aşamanın bir sonraki performans ve tekniği güçlendirmesi esas alınmıştır. Bu çalışmada staccato tekniğinin hangi alanlarda kullanıldığı, nasıl sonuçlar elde edildiği bilgisine yer verilmiştir. Notaların parmak ve dil uyumu ile nasıl şekilleneceği ve nasıl bir çalışma disiplini içinde gerçekleşeceği planlanmıştır. Kamış-nota-diyafram-parmak-dil-nüans ve disiplin kavramlarının staccato tekniğinde ayrılmaz bir bütün olduğu saptanmıştır. Araştırmada literatür taraması yapılarak staccato ile ilgili çalışmalar taranmıştır. Tarama sonucunda klarnet tekniğin de kullanılan staccato eser çalışmasının az olduğu tespit edilmiştir. Metot taramasında da etüt çalışmasının daha çok olduğu saptanmıştır. Böylelikle klarnetin staccato tekniğini hızlandırma ve güçlendirme çalışmaları sunulmuştur. Staccato etüt çalışmaları yapılırken, araya eser çalışmasının girmesi beyni rahatlattığı ve istekliliği daha arttırdığı gözlemlenmiştir. Staccato çalışmasını yaparken doğru bir kamış seçimi üzerinde de durulmuştur. Staccato tekniğini doğru çalışmak için doğru bir kamışın dil hızını arttırdığı saptanmıştır. Doğru bir kamış seçimi kamıştan rahat ses çıkmasına bağlıdır. Kamış, dil atma gücünü vermiyorsa daha doğru bir kamış seçiminin yapılması gerekliliği vurgulanmıştır. Staccato çalışmalarında baştan sona bir eseri yorumlamak zor olabilir. Bu açıdan çalışma, verilen müzikal nüanslara uymanın, dil atış performansını rahatlattığını ortaya koymuştur. Gelecek nesillere edinilen bilgi ve birikimlerin aktarılması ve geliştirici olması teşvik edilmiştir. Çıkacak eserlerin nasıl çözüleceği, staccato tekniğinin nasıl üstesinden gelinebileceği anlatılmıştır. Staccato tekniğinin daha kısa sürede çözüme kavuşturulması amaç edinilmiştir. Parmakların yerlerini öğrettiğimiz kadar belleğimize de çalışmaların kaydedilmesi önemlidir. Gösterilen azmin ve sabrın sonucu olarak ortaya çıkan yapıt başarıyı daha da yukarı seviyelere çıkaracaktır

    Towards A Graphene Chip System For Blood Clotting Disease Diagnostics

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    Point of care diagnostics (POCD) allows the rapid, accurate measurement of analytes near to a patient. This enables faster clinical decision making and can lead to earlier diagnosis and better patient monitoring and treatment. However, despite many prospective POCD devices being developed for a wide range of diseases this promised technology is yet to be translated to a clinical setting due to the lack of a cost-effective biosensing platform.This thesis focuses on the development of a highly sensitive, low cost and scalable biosensor platform that combines graphene with semiconductor fabrication tech-niques to create graphene field-effect transistors biosensor. The key challenges of designing and fabricating a graphene-based biosensor are addressed. This work fo-cuses on a specific platform for blood clotting disease diagnostics, but the platform has the capability of being applied to any disease with a detectable biomarker.Multiple sensor designs were tested during this work that maximised sensor ef-ficiency and costs for different applications. The multiplex design enabled different graphene channels on the same chip to be functionalised with unique chemistry. The Inverted MOSFET design was created, which allows for back gated measurements to be performed whilst keeping the graphene channel open for functionalisation. The Shared Source and Matrix design maximises the total number of sensing channels per chip, resulting in the most cost-effective fabrication approach for a graphene-based sensor (decreasing cost per channel from £9.72 to £4.11).The challenge of integrating graphene into a semiconductor fabrication process is also addressed through the development of a novel vacuum transfer method-ology that allows photoresist free transfer. The two main fabrication processes; graphene supplied on the wafer “Pre-Transfer” and graphene transferred after met-allisation “Post-Transfer” were compared in terms of graphene channel resistance and graphene end quality (defect density and photoresist). The Post-Transfer pro-cess higher quality (less damage, residue and doping, confirmed by Raman spec-troscopy).Following sensor fabrication, the next stages of creating a sensor platform involve the passivation and packaging of the sensor chip. Different approaches using dielec-tric deposition approaches are compared for passivation. Molecular Vapour Deposi-tion (MVD) deposited Al2O3 was shown to produce graphene channels with lower damage than unprocessed graphene, and also improves graphene doping bringing the Dirac point of the graphene close to 0 V. The packaging integration of microfluidics is investigated comparing traditional soft lithography approaches and the new 3D printed microfluidic approach. Specific microfluidic packaging for blood separation towards a blood sampling point of care sensor is examined to identify the laminar approach for lower blood cell count, as a method of pre-processing the blood sample before sensing.To test the sensitivity of the Post-Transfer MVD passivated graphene sensor de-veloped in this work, real-time IV measurements were performed to identify throm-bin protein binding in real-time on the graphene surface. The sensor was function-alised using a thrombin specific aptamer solution and real-time IV measurements were performed on the functionalised graphene sensor with a range of biologically relevant protein concentrations. The resulting sensitivity of the graphene sensor was in the 1-100 pg/ml concentration range, producing a resistance change of 0.2% per pg/ml. Specificity was confirmed using a non-thrombin specific aptamer as the neg-ative control. These results indicate that the graphene sensor platform developed in this thesis has the potential as a highly sensitive POCD. The processes developed here can be used to develop graphene sensors for multiple biomarkers in the future
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