Management of Febrile Neutropenia - a German Prospective Hospital Cost Analysis in Lymphoproliferative Disorders, Non-Small Cell Lung Cancer, and Primary Breast Cancer

Background: Febrile neutropenia/leukopenia (FN/FL) is the most frequent dose-limiting toxicity of myelosuppressive chemotherapy, but German data on economic consequences are limited. Patients and Methods: A prospective, multicentre, longitudinal, observational study was carried out to evaluate the occurrence of FN/FL and its impact on health resource utilization and costs in non-small cell lung cancer (NSCLC), lymphoproliferative disorder (LPD), and primary breast cancer (PBC) patients. Costs are presented from a hospital perspective. Results: A total of 325 consecutive patients (47% LPD, 37% NSCLC, 16% PBC; 46% women; 38% age >= 65 years) with 68 FN/FL episodes were evaluated. FN/FL occurred in 22% of the LPD patients, 8% of the NSCLC patients, and 27% of the PBC patients. 55 FN/FL episodes were associated with at least 1 hospital stay (LPD n = 34, NSCLC n = 10, PBC n = 11). Mean (median) cost per FN/FL episode requiring hospital care amounted to (sic) 3,950 ((sic) 2,355) and varied between (sic) 4,808 ((sic) 3,056) for LPD, (sic) 3,627 ((sic) 2,255) for NSCLC, and (sic) 1,827 ((sic) 1,969) for PBC patients. 12 FN/FL episodes (LPD n = 9, NSCLC n = 3) accounted for 60% of the total expenses. Main cost drivers were hospitalization and drugs (60 and 19% of the total costs). Conclusions: FN/FL treatment has economic relevance for hospitals. Costs vary between tumour types, being significantly higher for LPD compared to PBC patients. The impact of clinical characteristics on asymmetrically distributed costs needs further evaluation

Tri-Bimaximal Mixing from Twisted Friedberg-Lee Symmetry

We investigate the Friedberg-Lee (FL) symmetry and its promotion to include the $\mu - \tau$ symmetry, and call that the twisted FL symmetry.Based on the twisted FL symmetry, two possible schemes are presented toward the realistic neutrino mass spectrum and the tri-bimaximal mixing.In the first scheme, we suggest the semi-uniform translation of the FL symmetry.The second one is based on the $S_3$ permutation family symmetry.The breaking terms, which are twisted FL symmetric, are introduced.Some viable models in each scheme are also presented.Comment: 14 pages, no figure. v2: 16 pages, modified some sentences, appendix added, references added. v3: 14 pages, composition simplified, accepted version in EPJ

Study of Polarization in B -> VT Decays

In this paper, we examine B -> VT decays (V is a vector and T is a tensor meson), whose final-state particles can have transverse or longitudinal polarization. Measurements have been made of B -> \phi K_2^*, and it is found that fT/fL is small, where fT (fL) is the fraction of transverse (longitudinal) decays. We find that the standard model (SM) naively predicts that fT/fL << 1. The two extensions of the naive SM which have been proposed to explain the large fT/fL in B -> \phi K^* -- penguin annihilation and rescattering -- make no firm predictions for the polarization in B -> \phi K_2^*. The two new-physics scenarios, which explain the data in B -> \pi K and the \phi (\rho) K^* polarization measurements, can reproduce the fT/fL data in B -> \phi K_2^* only if the B -> T form factors obey a certain hierarchy. Finally, we present the general angular analysis which can be used to get helicity information using two- and three-body decays.Comment: 15 pages, latex, 3 figures (enclosed), several changes made, conclusions unchanged, publication info adde

Dynamics of Fluxon Lattice in Two Coupled Josephson Junctions

We study theoretically the dynamics of a fluxon Lattice (FL) in two coupled Josephson junctions. We show that when the velocity of the moving FL exceeds certain values $(V_{a,b})$, sharp resonances arise in the system which are related to the excitation of the optical and acoustic collective modes. In the interval $(V_a, V_b)$ a reconstruction of the FL occurs. We also establish that one can excite localized nonlinear distortions (dislocations) which may propagate through the FL and carry an arbitrary magnetic flux.Comment: 4 pages, 3 figures, corected typo

Constraints of FL Motif on the Targeting and Function of Sodium-Bicarbonate Cotransporter 1

A C-terminal dihydrophobic FL motif plays a vital role in the basolateral targeting of sodium bicarbonate cotransporter 1. To further characterize the role of dihydrophobic FL motif, 1). the FL motif in wild type (PFLS) was reversed to LF (PLFS), 2). the FL motif (PFLS) was shifted upstream (FLPS), and 3). the FL motif (PFLS) was shifted downstream (PSFL). The wild type (PFLS) and its mutant (PLFS) were exclusively expressed on the basolateral membrane by con-focal microscopy, however, the mutant (FLPS) and (PSFL) were predominantly mistargeted to the apical membrane and the cytoplasm, respectively. Functional studies showed that the mutant (PSFL) displayed a remarkably reduced current (p value&#x3c;0.05 vs wild type). The mutant (PSFL) displayed a more reduced membrane surface expression than the wild type and was co-localized with ER marker. The protein sequence spanning FL motif in kNBC1 C-terminal cytoplasmic tail shows a helical structure, mutants (PLFS) and (PSFL) reduce a-helical contents by circular dichroism study. Reversed FL isn&#x27;t a constraint for basolateral targeting, but shifting it upstream and downstream are ones

2'-fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice.

Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety signaling, which may be due in part to gut microbial dysbiosis. Manipulations of the gut microbiota and its metabolites are attractive targets for obesity treatment. The predominant oligosaccharide found in human milk, acts as a prebiotic with beneficial effects on the host. However, little is known about the beneficial effects of 2'-FL in obesity. The aim of this study was to determine the beneficial effects of 2'-FL supplementation on the microbiota-gut-brain axis and the diet-induced obese phenotype in high fat (HF)-fed mice. Male C57/BL6 mice (n = 6/group; six weeks old) were counter-balanced into six weight-matched groups and fed either a low-fat (LF; 10% kcal as fat), HF (45% kcal as fat) or HF diet with 2'-FL (HF_2'-FL) at 1, 2, 5 and 10% (w/v) in drinking water for six weeks. General phenotypes (body weight, energy intake, fat and lean mass), cecal microbiome and metabolites, gut-brain signaling, intestinal permeability and inflammatory and lipid profiles were assessed. Only 10% 2'-FL, but not 1, 2 or 5%, decreased HF diet-induced increases in energy intake, fat mass and body weight gain. A supplementation of 10% 2'-FL changed the composition of cecal microbiota and metabolites compared to LF- and HF-fed mice with an increase in Parabacteroides abundance and lactate and pyruvate, respectively, whose metabolic effects corresponded to our study findings. In particular, 10% 2'-FL significantly reversed the HF diet-induced impairment of cholecystokinin-induced inhibition of food intake. Gene expressions of interleukin (IL)-1β, IL-6, and macrophage chemoattractant protein-1 in the cecum were significantly downregulated by 10% 2'-FL compared to the HF group. Furthermore, 10% 2'-FL suppressed HF diet-induced upregulation of hepatic peroxisome proliferator-activated receptor gamma, a transcription factor for adipogenesis, at the gene level. In conclusion, 10% 2'-FL led to compositional changes in gut microbiota and metabolites associated with improvements in metabolic profiles and gut-brain signaling in HF-fed mice. These findings support the use of 2'-FL for modulating the hyperphagic response to HF diets and improving the microbiota-gut-brain axis