Mechanisms of Action and Targets of Nitric Oxide in the Oculomotor System

Nitric oxide (NO) production by neurons in the prepositus hypoglossi (PH) nucleus is necessary for the normal performance of eye movements in alert animals. In this study, the mechanism(s) of action of NO in the oculomotor system has been investigated. Spontaneous and vestibularly induced eye movements were recorded in alert cats before and after microinjections in the PH nucleus of drugs affecting the NO–cGMP pathway. The cellular sources and targets of NO were also studied by immunohistochemical detection of neuronal NO synthase (NOS) and NO-sensitive guanylyl cyclase, respectively. Injections of NOS inhibitors produced alterations of eye velocity, but not of eye position, for both spontaneous and vestibularly induced eye movements, suggesting that NO produced by PH neurons is involved in the processing of velocity signals but not in the eye position generation. The effect of neuronal NO is probably exerted on a rich cGMP-producing neuropil dorsal to the nitrergic somas in the PH nucleus. On the other hand, local injections of NO donors or 8-Br-cGMP produced alterations of eye velocity during both spontaneous eye movements and vestibulo-ocular reflex (VOR), as well as changes in eye position generation exclusively during spontaneous eye movements. The target of this additional effect of exogenous NO is probably a well defined group of NO-sensitive cGMP-producing neurons located between the PH and the medial vestibular nuclei. These cells could be involved in the generation of eye position signals during spontaneous eye movements but not during the VOR.Fondo de Investigación Sanitaria Grants 94/0388 and 97/2054Comunidad Autónoma de Madrid Grant 08.5/0019/1997Dirección General de Investigación Científica y Technológica Grant PB 93–117

Paroxysmal eye–head movements in Glut1 deficiency syndrome

Objective:To describe a characteristic paroxysmal eye–head movement disorder that occurs in infants with Glut1 deficiency syndrome (Glut1 DS).Methods:We retrospectively reviewed the medical charts of 101 patients with Glut1 DS to obtain clinical data about episodic abnormal eye movements and analyzed video recordings of 18 eye movement episodes from 10 patients.Results:A documented history of paroxysmal abnormal eye movements was found in 32/101 patients (32%), and a detailed description was available in 18 patients, presented here. Episodes started before age 6 months in 15/18 patients (83%), and preceded the onset of seizures in 10/16 patients (63%) who experienced both types of episodes. Eye movement episodes resolved, with or without treatment, by 6 years of age in 7/8 patients with documented long-term course. Episodes were brief (usually &lt;5 minutes). Video analysis revealed that the eye movements were rapid, multidirectional, and often accompanied by a head movement in the same direction. Eye movements were separated by clear intervals of fixation, usually ranging from 200 to 800 ms. The movements were consistent with eye–head gaze saccades. These movements can be distinguished from opsoclonus by the presence of a clear intermovement fixation interval and the association of a same-direction head movement.Conclusions:Paroxysmal eye–head movements, for which we suggest the term aberrant gaze saccades, are an early symptom of Glut1 DS in infancy. Recognition of the episodes will facilitate prompt diagnosis of this treatable neurodevelopmental disorder.</jats:sec

Recent Saccadic Eye Movement Research Uncovers Patterns of Cognitive Dysfunction in Schizophrenia.

The frontal cortex and the subcortical areas of the brain play a major role in the control of thought and action. Eye movements are increasingly used in neuropsychological research to explore the executive and sensorimotor functions of such neural networks. This interface links the control of action, at the fundamental levels of neurophysiological and neurochemical processes, with the high-level cognitive operations that underlie visual orienting. Patients with schizophrenia have neurocognitive impairments that can be readily investigated with novel saccadic eye movement paradigms. Animal, human lesion, and neuroimaging studies have identified the cerebral centers that underlie saccadic eye movements. The areas of the prefrontal cortex include the dorsolateral prefrontal cortex, the frontal eye fields, the supplementary eye fields, and the anterior cingulate gyrus. Pathology of saccadic eye movements therefore provides information on the functional status of the underlying neural circuitry in brain disorders such as schizophrenia

Measuring miniature eye movements by means of a SQUID magnetometer

A new technique to measure small eye movements is reported. The precise recording of human eye movements is necessary for research on visual fatigue induced by visual display units.1 So far all methods used have disadvantages: especially those which are sensitive or are rather painful.2,3 Our method is based on a transformation of mechanical vibrations into magnetic flux variations. In order to do this a small magnet is embedded in a close-fitting soft contact lens. The magnetic flux variations caused by eyeball movements during fixation are measured by means of a SQUID magnetometer. The recordings show the typical fixation pattern of a human eye. This pattern is composed of three kinds of movements: saccades, drift and microtremor. The last-mentioned type of movements are displacements in the order of 2 μm. It is possible to distinguish between movements which are perpendicular to each other

Quantum Brain: A Recurrent Quantum Neural Network Model to Describe Eye Tracking of Moving Targets

A theoretical quantum brain model is proposed using a nonlinear Schroedinger wave equation. The model proposes that there exists a quantum process that mediates the collective response of a neural lattice (classical brain). The model is used to explain eye movements when tracking moving targets. Using a Recurrent Quantum Neural Network(RQNN) while simulating the quantum brain model, two very interesting phenomena are observed. First, as eye sensor data is processed in a classical brain, a wave packet is triggered in the quantum brain. This wave packet moves like a particle. Second, when the eye tracks a fixed target, this wave packet moves not in a continuous but rather in a discrete mode. This result reminds one of the saccadic movements of the eye consisting of 'jumps' and 'rests'. However, such a saccadic movement is intertwined with smooth pursuit movements when the eye has to track a dynamic trajectory. In a sense, this is the first theoretical model explaining the experimental observation reported concerning eye movements in a static scene situation. The resulting prediction is found to be very precise and efficient in comparison to classical objective modeling schemes such as the Kalman filter.Comment: 7 pages, 7 figures submitted to Physical Review Letter

Exploration of the functional consequences of fixational eye movements in the absence of a fovea.

A recent theory posits that ocular drifts of fixational eye movements serve to reformat the visual input of natural images, so that the power of the input image is equalized across a range of spatial frequencies. This "spectral whitening" effect is postulated to improve the processing of high-spatial-frequency information and requires normal fixational eye movements. Given that people with macular disease exhibit abnormal fixational eye movements, do they also exhibit spectral whitening? To answer this question, we computed the power spectral density of movies of natural images translated in space and time according to the fixational eye movements (thus simulating the retinal input) of a group of observers with long-standing bilateral macular disease. Just as for people with normal vision, the power of the retinal input at low spatial frequencies was lower than that based on the 1/f2 relationship, demonstrating spectral whitening. However, the amount of whitening was much less for observers with macular disease when compared with age-matched controls with normal vision. A mediation analysis showed that the eccentricity of the preferred retinal locus adopted by these observers and the characteristics of ocular drifts are important factors limiting the amount of whitening. Finally, we did not find a normal aging effect on spectral whitening. Although these findings alone cannot form a causal link between macular disease and spectral properties of eye movements, they suggest novel potential means of modifying the characteristics of fixational eye movements, which may in turn improve functional vision for people with macular disease

Brief report: how adolescents with ASD process social information in complex scenes. Combining evidence from eye movements and verbal descriptions

We investigated attention, encoding and processing of social aspects of complex photographic scenes. Twenty-four high-functioning adolescents (aged 11–16) with ASD and 24 typically developing matched control participants viewed and then described a series of scenes, each containing a person. Analyses of eye movements and verbal descriptions provided converging evidence that both groups displayed general interest in the person in each scene but the salience of the person was reduced for the ASD participants. Nevertheless, the verbal descriptions revealed that participants with ASD frequently processed the observed person’s emotion or mental state without prompting. They also often mentioned eye-gaze direction, and there was evidence from eye movements and verbal descriptions that gaze was followed accurately. The combination of evidence from eye movements and verbal descriptions provides a rich insight into the way stimuli are processed overall. The merits of using these methods within the same paradigm are discussed

Eye movements in surgery: A literature review

With recent advances in eye tracking technology, it is now possible to track surgeons’ eye movements while engaged in a surgical task or when surgical residents practice their surgical skills. Several studies have compared eye movements of surgical experts and novices, developed techniques to assess surgical skill on the basis of eye movements, and examined the role of eye movements in surgical training. We here provide an overview of these studies with a focus on the methodological aspects. We conclude that the different studies of eye movements in surgery suggest that the recording of eye movements may be beneficial both for skill assessment and training purposes, although more research will be needed in this field

Eye movements may cause motor contagion effects

When a person executes a movement, the movement is more errorful while observing another person’s actions that are incongruent rather than congruent with the executed action. This effect is known as “motor contagion”. Accounts of this effect are often grounded in simulation mechanisms: increased movement error emerges because the motor codes associated with observed actions compete with motor codes of the goal action. It is also possible, however, that the increased movement error is linked to eye movements that are executed simultaneously with the hand movement because oculomotor and manual-motor systems are highly interconnected. In the present study, participants performed a motor contagion task in which they executed horizontal arm movements while observing a model making either vertical (incongruent) or horizontal (congruent) movements under three conditions: no instruction, maintain central fixation, or track the model’s hand with the eyes. A significant motor contagion-like effect was only found in the ‘track’ condition. Thus, ‘motor contagion’ in the present task may be an artifact of simultaneously executed incongruent eye movements. These data are discussed in the context of stimulation and associative learning theories, and raise eye movements as a critical methodological consideration for future work on motor contagion

Scaling of Horizontal and Vertical Fixational Eye Movements

Eye movements during fixation of a stationary target prevent the adaptation of the photoreceptors to continuous illumination and inhibit fading of the image. These random, involuntary, small, movements are restricted at long time scales so as to keep the target at the center of the field of view. Here we use the Detrended Fluctuation Analysis (DFA) in order to study the properties of fixational eye movements at different time scales. Results show different scaling behavior between horizontal and vertical movements. When the small ballistics movements, i.e. micro-saccades, are removed, the scaling exponents in both directions become similar. Our findings suggest that micro-saccades enhance the persistence at short time scales mostly in the horizontal component and much less in the vertical component. This difference may be due to the need of continuously moving the eyes in the horizontal plane, in order to match the stereoscopic image for different viewing distance.Comment: 5 pages, 4 figure