10,672 research outputs found
Genetic Programming for Multibiometrics
Biometric systems suffer from some drawbacks: a biometric system can provide
in general good performances except with some individuals as its performance
depends highly on the quality of the capture. One solution to solve some of
these problems is to use multibiometrics where different biometric systems are
combined together (multiple captures of the same biometric modality, multiple
feature extraction algorithms, multiple biometric modalities...). In this
paper, we are interested in score level fusion functions application (i.e., we
use a multibiometric authentication scheme which accept or deny the claimant
for using an application). In the state of the art, the weighted sum of scores
(which is a linear classifier) and the use of an SVM (which is a non linear
classifier) provided by different biometric systems provide one of the best
performances. We present a new method based on the use of genetic programming
giving similar or better performances (depending on the complexity of the
database). We derive a score fusion function by assembling some classical
primitives functions (+, *, -, ...). We have validated the proposed method on
three significant biometric benchmark datasets from the state of the art
Designing labeled graph classifiers by exploiting the R\'enyi entropy of the dissimilarity representation
Representing patterns as labeled graphs is becoming increasingly common in
the broad field of computational intelligence. Accordingly, a wide repertoire
of pattern recognition tools, such as classifiers and knowledge discovery
procedures, are nowadays available and tested for various datasets of labeled
graphs. However, the design of effective learning procedures operating in the
space of labeled graphs is still a challenging problem, especially from the
computational complexity viewpoint. In this paper, we present a major
improvement of a general-purpose classifier for graphs, which is conceived on
an interplay between dissimilarity representation, clustering,
information-theoretic techniques, and evolutionary optimization algorithms. The
improvement focuses on a specific key subroutine devised to compress the input
data. We prove different theorems which are fundamental to the setting of the
parameters controlling such a compression operation. We demonstrate the
effectiveness of the resulting classifier by benchmarking the developed
variants on well-known datasets of labeled graphs, considering as distinct
performance indicators the classification accuracy, computing time, and
parsimony in terms of structural complexity of the synthesized classification
models. The results show state-of-the-art standards in terms of test set
accuracy and a considerable speed-up for what concerns the computing time.Comment: Revised versio
Identification of disease-causing genes using microarray data mining and gene ontology
Background: One of the best and most accurate methods for identifying disease-causing genes is monitoring gene expression values in different samples using microarray technology. One of the shortcomings of microarray data is that they provide a small quantity of samples with respect to the number of genes. This problem reduces the classification accuracy of the methods, so gene selection is essential to improve the predictive accuracy and to identify potential marker genes for a disease. Among numerous existing methods for gene selection, support vector machine-based recursive feature elimination (SVMRFE) has become one of the leading methods, but its performance can be reduced because of the small sample size, noisy data and the fact that the method does not remove redundant genes.
Methods: We propose a novel framework for gene selection which uses the advantageous features of conventional methods and addresses their weaknesses. In fact, we have combined the Fisher method and SVMRFE to utilize the advantages of a filtering method as well as an embedded method. Furthermore, we have added a redundancy reduction stage to address the weakness of the Fisher method and SVMRFE. In addition to gene expression values, the proposed method uses Gene Ontology which is a reliable source of information on genes. The use of Gene Ontology can compensate, in part, for the limitations of microarrays, such as having a small number of samples and erroneous measurement results.
Results: The proposed method has been applied to colon, Diffuse Large B-Cell Lymphoma (DLBCL) and prostate cancer datasets. The empirical results show that our method has improved classification performance in terms of accuracy, sensitivity and specificity. In addition, the study of the molecular function of selected genes strengthened the hypothesis that these genes are involved in the process of cancer growth.
Conclusions: The proposed method addresses the weakness of conventional methods by adding a redundancy reduction stage and utilizing Gene Ontology information. It predicts marker genes for colon, DLBCL and prostate cancer with a high accuracy. The predictions made in this study can serve as a list of candidates for subsequent wet-lab verification and might help in the search for a cure for cancers
Elephant Search with Deep Learning for Microarray Data Analysis
Even though there is a plethora of research in Microarray gene expression
data analysis, still, it poses challenges for researchers to effectively and
efficiently analyze the large yet complex expression of genes. The feature
(gene) selection method is of paramount importance for understanding the
differences in biological and non-biological variation between samples. In
order to address this problem, a novel elephant search (ES) based optimization
is proposed to select best gene expressions from the large volume of microarray
data. Further, a promising machine learning method is envisioned to leverage
such high dimensional and complex microarray dataset for extracting hidden
patterns inside to make a meaningful prediction and most accurate
classification. In particular, stochastic gradient descent based Deep learning
(DL) with softmax activation function is then used on the reduced features
(genes) for better classification of different samples according to their gene
expression levels. The experiments are carried out on nine most popular Cancer
microarray gene selection datasets, obtained from UCI machine learning
repository. The empirical results obtained by the proposed elephant search
based deep learning (ESDL) approach are compared with most recent published
article for its suitability in future Bioinformatics research.Comment: 12 pages, 5 Tabl
Open-Category Classification by Adversarial Sample Generation
In real-world classification tasks, it is difficult to collect training
samples from all possible categories of the environment. Therefore, when an
instance of an unseen class appears in the prediction stage, a robust
classifier should be able to tell that it is from an unseen class, instead of
classifying it to be any known category. In this paper, adopting the idea of
adversarial learning, we propose the ASG framework for open-category
classification. ASG generates positive and negative samples of seen categories
in the unsupervised manner via an adversarial learning strategy. With the
generated samples, ASG then learns to tell seen from unseen in the supervised
manner. Experiments performed on several datasets show the effectiveness of
ASG.Comment: Published in IJCAI 201
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