Exploiting Constraints in the Codeword Design

The sequence design is a crucial problem in DNA based computation. We present results about tests carried on sets of DNA strands proposed in DNA computing papers since 1994. Our goal is to direct attention on the necessity of a middle-process between logical designing of input and practical computation in laboratory. The analysis shows that many input sets should not be used for a real DNA computation because they lead to a high probability of incurring in biological faults which result to be very unsafe for a reliable computation