688,571 research outputs found

    Large‐Amplitude Mountain Waves in the Mesosphere Observed on 21 June 2014 During DEEPWAVE: 2. Nonlinear Dynamics, Wave Breaking, and Instabilities

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    Weak cross‐mountain flow over the New Zealand South Island on 21 June 2014 during the Deep Propagating Gravity Wave Experiment (DEEPWAVE) led to large‐amplitude mountain waves in the mesosphere and lower thermosphere. The mesosphere and lower thermosphere responses were observed by ground‐based instruments in the lee of the Southern Alps supporting DEEPWAVE, including an Advanced Mesosphere Temperature Mapper, a Rayleigh lidar, an All‐Sky Imager, and a Fabry‐Perot Interferometer. The character of the mountain wave responses at horizontal scales of ~30–90 km reveals strong “sawtooth” variations in the temperature field suggesting large vertical and horizontal displacements leading to mountain wave overturning. The observations also reveal multiple examples of apparent instability structures within the mountain wave field that arose accompanying large amplitudes and exhibited various forms, scales, and evolutions. This paper employs detailed data analyses and results of numerical modeling of gravity wave instability dynamics to interpret these mountain wave dynamics, their instability forms, scales, and expected environmental influences. Results demonstrate apparently general instability pathways for breaking of large‐amplitude gravity waves in environments without and with mean shear. A close link is also found between large‐amplitude gravity waves and the dominant instability scales that may yield additional abilities to quantify gravity wave characteristics and effects

    Program representation size in an intermediate language with intersection and union types

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    The CIL compiler for core Standard ML compiles whole programs using a novel typed intermediate language (TIL) with intersection and union types and flow labels on both terms and types. The CIL term representation duplicates portions of the program where intersection types are introduced and union types are eliminated. This duplication makes it easier to represent type information and to introduce customized data representations. However, duplication incurs compile-time space costs that are potentially much greater than are incurred in TILs employing type-level abstraction or quantification. In this paper, we present empirical data on the compile-time space costs of using CIL as an intermediate language. The data shows that these costs can be made tractable by using sufficiently fine-grained flow analyses together with standard hash-consing techniques. The data also suggests that non-duplicating formulations of intersection (and union) types would not achieve significantly better space complexity.National Science Foundation (CCR-9417382, CISE/CCR ESS 9806747); Sun grant (EDUD-7826-990410-US); Faculty Fellowship of the Carroll School of Management, Boston College; U.K. Engineering and Physical Sciences Research Council (GR/L 36963, GR/L 15685

    Study of the correlation between bicuspid aortic valve and the development of aortic dissection

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    La disección aórtica (AD) es la condición letal más comúnmente diagnosticada de la arteria aorta y consiste en el redireccionamiento del flujo sanguíneo desde el lumen de la aorta hasta la media de la pared de la aorta a través de una pequeña fisura en la intima. Las causas específicas de la formación de esta fisura, y de la subsecuente dilatación de la pared, todavía no han sido completamente determinadas aunque diversos estudios muestran que puede ser debida o bien a cambios químicos o bien a efectos mecánicos en la pared de la aorta. Este trabajo se centra en el estudio de posibles efectos mecánicos, inducidos por cambios en la hemodinámica de la arteria, que puedan haber conducido al debilitamiento de la pared de la aorta. Válvula aórtica bicúspide (BAV) es la enfermedad congénita del corazón más común y se ha demostrado su importante contribución en el desarrollo de numerosas condiciones cardiovasculares. Esta enfermedad modifica el orificio de salida del corazón, y por tanto el perfil hemodinámico de eyección, del flujo de sangre, lo que podría tener consecuencias en el comportamiento mecánico de la pared de la aorta. Este estudio tiene como objetivo determinar que existe una correlación entre los cambios en la hemodinámica producidos por la presencia de BAV y la formación de AD usando técnicas de análisis de dinámica de fluidos computacional (CFD). Para determinar dicha relación, análisis CFD se han realizado en tres geometrías diferentes: un caso de válvula aórtica tricúspide (TAV) y dos casos distintos de BAV. Todas las geometrías son idealizadas y contemplan la raíz de la aorta, la aorta ascendente y el comienzo del cayado aórtico. Los resultados de los análisis muestran un incremento en la velocidad de eyección de la sangre para ambos casos de BAV debido a la reducción en el área efectiva del orificio. Además, el estudio muestra un incremento en las fuerzas de rozamiento de la pared y en la presión de la pared externa de la aorta. Estos resultados nos llevan a la conclusión de que BAV podría causar hipertensión en la pared externa de la aorta, la cual es una causa mecánica conocida del debilitamiento de vasos sanguíneos

    Pacific Salmon, Oncorhynchus spp., and the Definition of "Species" Under the Endangered Species Act

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    For purposes ofthe Endangered Species Act (ESA), a "species" is defined to include "any distinct population segment of any species of vertebrate fish or wildlife which interbreeds when mature. "Federal agencies charged with carrying out the provisions of the ESA have struggled for over a decade to develop a consistent approach for interpreting the term "distinct population segment." This paper outlines such an approach and explains in some detail how it can be applied to ESA evaluations of anadromous Pacific salmonids. The following definition is proposed: A population (or group of populations) will be considered "distinct" (and hence a "species ")for purposes of the ESA if it represents an evolutionarily significant unit (ESU) of the biological species. A population must satisfy two criteria to be considered an ESU: 1) It must be substantially reproductively isolated from other conspecific population units, and 2) It must represent an important component in the evolutionary legacy of the species. Isolation does not have to be absolute, but it must be strong enough to permit evolutionarily important differences to accrue in different population units. The second criterion would be met if the population contributes substantially to the ecological/genetic diversity of the species as a whole. Insights into the extent of reproductive isolation can be provided by movements of tagged fish, natural recolonization rates observed in other populations, measurements of genetic differences between populations, and evaluations of the efficacy of natural barriers. Each of these methods has its limitations. Identification of physical barriers to genetic exchange can help define the geographic extent of distinct populations, but reliance on physical features alone can be misleading in the absence of supporting biological information. Physical tags provide information about the movements of individual fish but not the genetic consequences of migration. Furthermore, measurements ofc urrent straying or recolonization rates provide no direct information about the magnitude or consistency of such rates in the past. In this respect, data from protein electrophoresis or DNA analyses can be very useful because they reflect levels of gene flow that have occurred over evolutionary time scales. The best strategy is to use all available lines of evidence for or against reproductive isolation, recognizing the limitations of each and taking advantage of the often complementary nature of the different types of information. If available evidence indicates significant reproductive isolation, the next step is to determine whether the population in question is of substantial ecological/genetic importance to the species as a whole. In other words, if the population became extinct, would this event represent a significant loss to the ecological/genetic diversity of thes pecies? In making this determination, the following questions are relevant: 1) Is the population genetically distinct from other conspecific populations? 2) Does the population occupy unusual or distinctive habitat? 3) Does the population show evidence of unusual or distinctive adaptation to its environment? Several types of information are useful in addressing these questions. Again, the strengths and limitations of each should be kept in mind in making the evaluation. Phenotypic/life-history traits such as size, fecundity, and age and time of spawning may reflect local adaptations of evolutionary importance, but interpretation of these traits is complicated by their sensitivity to environmental conditions. Data from protein electrophoresis or DNA analyses provide valuable insight into theprocessofgenetic differentiation among populations but little direct information regarding the extent of adaptive genetic differences. Habitat differences suggest the possibility for local adaptations but do not prove that such adaptations exist. The framework suggested here provides a focal point for accomplishing the majorgoal of the Act-to conserve the genetic diversity of species and the ecosystems they inhabit. At the same time, it allows discretion in the listing of populations by requiring that they represent units of real evolutionary significance to the species. Further, this framework provides a means of addressing several issues of particular concern for Pacific salmon, including anadromous/nonanadromous population segments, differences in run-timing, groups of populations, introduced populations, and the role of hatchery fish

    The genetic architecture underlying the evolution of a rare piscivorous life history form in brown trout after secondary contact and strong introgression

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    Identifying the genetic basis underlying phenotypic divergence and reproductive isolation is a longstanding problem in evolutionary biology. Genetic signals of adaptation and reproductive isolation are often confounded by a wide range of factors, such as variation in demographic history or genomic features. Brown trout ( ) in the Loch Maree catchment, Scotland, exhibit reproductively isolated divergent life history morphs, including a rare piscivorous (ferox) life history form displaying larger body size, greater longevity and delayed maturation compared to sympatric benthivorous brown trout. Using a dataset of 16,066 SNPs, we analyzed the evolutionary history and genetic architecture underlying this divergence. We found that ferox trout and benthivorous brown trout most likely evolved after recent secondary contact of two distinct glacial lineages, and identified 33 genomic outlier windows across the genome, of which several have most likely formed through selection. We further identified twelve candidate genes and biological pathways related to growth, development and immune response potentially underpinning the observed phenotypic differences. The identification of clear genomic signals divergent between life history phenotypes and potentially linked to reproductive isolation, through size assortative mating, as well as the identification of the underlying demographic history, highlights the power of genomic studies of young species pairs for understanding the factors shaping genetic differentiation

    Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE

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    The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second receptor for Tf, TfR2, was recently identified and found to be functional for iron uptake in transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W., and Koeffler, H. P. (2000) J. Biol. Chem. 275, 16618-16625). TfR2 has a pattern of expression and regulation that is distinct from TfR, and mutations in TfR2 have been recognized as the cause of a non-HFE linked form of hemochromatosis (Camaschella, C., Roetto, A., Cali, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A., and Gasparini, P. (2000) Nat. Genet. 25, 14-15). To investigate the relationship between TfR, TfR2, Tf, and HFE, we performed a series of binding experiments using soluble forms of these proteins. We find no detectable binding between TfR2 and HFE by co-immunoprecipitation or using a surface plasmon resonance-based assay. The affinity of TfR2 for iron-loaded Tf was determined to be 27 nM, 25-fold lower than the affinity of TfR for Tf. These results imply that HFE regulates Tf-mediated iron uptake only from the classical TfR and that TfR2 does not compete for HFE binding in cells expressing both forms of TfR
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