Oxidative Stress and Inflammation

In the biochemical reactions that take place within all living beings, species called free radicals are generated. Denham Harman, in his study on the origin and evolution of life (Harman, 2001), proposes that these species are amongst the causes of the origin of life on our planet. Oxygen is a molecule that provides the primary source of energy in aerobic organisms and therefore is key to the development and evolution of life. On the one hand, it gives rise to life; on the other, due to its ability to form different free radicals, it is capable of damaging essential structures for development. To combat these radicals, our biological systems have developed antioxidant defenses. However, when the balance between free radicals and antioxidant defenses is broken in favor of the former, a phenomenon called oxidative stress occurs, which ends up damaging molecules such as DNA, proteins, carbohydrates, and lipids (Sies, 1983) (Halliwell and Gutteridge, 1985). This phenomenon is implicated both in the development of diseases and in their progression. In addition, inflammation phenomena are also involved in most pathologies, which, although they are essential for tissue repair and immunity, turn against our bodies when they become excessively active. For these reasons, in this special edition we showcase an extensive knowledge of the effects of oxidative stress and inflammation both in diseases such as aging, or for its role in health

Program and abstracts

We are pleased that the program in 2022 will be more interesting than ever and it will include the following topics: Mathematical Modeling in Cancer Therapy, Gene Therapy, Archaeological Genetics, New perspectives in Human Forensic Molecular Biology, Genomics in Medicine, Pharmacogenomics and Drug Development, Stem Cells in Medicine, Regenerative Medicine, Ribosomes in Medicine, Epigenomics, Crime Scene Investigation, Forensic Genetics, and Mass Catastrophes Managements. This year, the third "Nobel Spirit" will provide a forum to the three Nobel laureates to stimulate public discussion on the role of science in solving global health issues, acute regional problems such as brain drain, demographic decline, as well as cultural and social change. In addition, we are organizing a very stimulating Session on Bioanthropology and global health in the times of crisis, as well as Joint Event ISABS and Ministry of the Interior - Crime Scene Investigation Training Course: Mystery on the ship —Investigation of the water-related crime scene

日本医科大学研究業績年報 第56巻 平成21(2009年度)

日本医科大