Fast Exact Algorithms Using Hadamard Product of Polynomials

Let C be an arithmetic circuit of poly(n) size given as input that computes a polynomial f in F[X], where X={x_1,x_2,...,x_n} and F is any field where the field arithmetic can be performed efficiently. We obtain new algorithms for the following two problems first studied by Koutis and Williams [Ioannis Koutis, 2008; Ryan Williams, 2009; Ioannis Koutis and Ryan Williams, 2016]. - (k,n)-MLC: Compute the sum of the coefficients of all degree-k multilinear monomials in the polynomial f. - k-MMD: Test if there is a nonzero degree-k multilinear monomial in the polynomial f. Our algorithms are based on the fact that the Hadamard product f o S_{n,k}, is the degree-k multilinear part of f, where S_{n,k} is the k^{th} elementary symmetric polynomial. - For (k,n)-MLC problem, we give a deterministic algorithm of run time O^*(n^(k/2+c log k)) (where c is a constant), answering an open question of Koutis and Williams [Ioannis Koutis and Ryan Williams, 2016]. As corollaries, we show O^*(binom{n}{downarrow k/2})-time exact counting algorithms for several combinatorial problems: k-Tree, t-Dominating Set, m-Dimensional k-Matching. - For k-MMD problem, we give a randomized algorithm of run time 4.32^k * poly(n,k). Our algorithm uses only poly(n,k) space. This matches the run time of a recent algorithm [Cornelius Brand et al., 2018] for k-MMD which requires exponential (in k) space. Other results include fast deterministic algorithms for (k,n)-MLC and k-MMD problems for depth three circuits

Transfected poly(I:C) activates different dsRNA receptors leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells

Background: Castration-resistant prostate cancer (CRPC) is refractory to chemo-radiotherapy. Results: Transfection of the synthetic analog of dsRNA poly(I:C) simultaneously stimulates apoptosis and IFN- expression through different pathways in androgen-independent prostate cancer (PCa) cells. Conclusion: Dual parallel pathways triggered by distinct receptors activate direct and immunologically mediated antitumor effects in advanced PCa. Significance: The proapoptotic/immunoadjuvant poly(I:C)-Lipofectamine complex may offer new therapeutic insights into CRPC

Exchangeable Variable Models

A sequence of random variables is exchangeable if its joint distribution is invariant under variable permutations. We introduce exchangeable variable models (EVMs) as a novel class of probabilistic models whose basic building blocks are partially exchangeable sequences, a generalization of exchangeable sequences. We prove that a family of tractable EVMs is optimal under zero-one loss for a large class of functions, including parity and threshold functions, and strictly subsumes existing tractable independence-based model families. Extensive experiments show that EVMs outperform state of the art classifiers such as SVMs and probabilistic models which are solely based on independence assumptions.Comment: ICML 201

Noise-Resilient Group Testing with Order-Optimal Tests and Fast-and-Reliable Decoding

Group testing (GT) is the Boolean counterpart of compressed sensing and the marketplace of new ideas for related problems such as cognitive radio and heavy hitter. A GT scheme is considered good if it is nonadaptive, uses $O(k \log n)$ tests, resists noise, can be decoded in $O(k \operatorname{poly}(\log n))$ time, and makes nearly no mistakes. In this paper, we propose "Gacha GT", an elementary, self-contained, and unified randomized scheme that, for the first time, satisfies all criteria for a fairly large region of parameters, namely when $\log k < \log(n)^{1-1/O(1)}$. Outside this parameter region, Gacha can be specialized to outperform the state-of-the-art partial-recovery GTs, exact-recovery GTs, and worst-case GTs. The new idea that runs through this paper, using an analogy, is to ask every person to break her $9$-digit "phone number" into three $3$-digit numbers $x$, $y$, and $z$ and write $(b, x)$, $(b, y)$, and $(b, z)$ on three pieces of sticky notes, where $b$ is her "birthday". This way, one can sort the sticky notes by birthday to reassemble the phone numbers. This birthday--number code and other coded constructions can be stacked like a multipartite graph pyramid. Gacha's encoder will synthesize the test results from the bottom up; and Gacha's decoder will reassemble the phone numbers from the top down.Comment: 23 pages, 8 figure