18,212 research outputs found
A survey of random processes with reinforcement
The models surveyed include generalized P\'{o}lya urns, reinforced random
walks, interacting urn models, and continuous reinforced processes. Emphasis is
on methods and results, with sketches provided of some proofs. Applications are
discussed in statistics, biology, economics and a number of other areas.Comment: Published at http://dx.doi.org/10.1214/07-PS094 in the Probability
Surveys (http://www.i-journals.org/ps/) by the Institute of Mathematical
Statistics (http://www.imstat.org
Modeling the ballistic-to-diffusive transition in nematode motility reveals variation in exploratory behavior across species
A quantitative understanding of organism-level behavior requires predictive
models that can capture the richness of behavioral phenotypes, yet are simple
enough to connect with underlying mechanistic processes. Here we investigate
the motile behavior of nematodes at the level of their translational motion on
surfaces driven by undulatory propulsion. We broadly sample the nematode
behavioral repertoire by measuring motile trajectories of the canonical lab
strain N2 as well as wild strains and distant species. We focus on
trajectory dynamics over timescales spanning the transition from ballistic
(straight) to diffusive (random) movement and find that salient features of the
motility statistics are captured by a random walk model with independent
dynamics in the speed, bearing and reversal events. We show that the model
parameters vary among species in a correlated, low-dimensional manner
suggestive of a common mode of behavioral control and a trade-off between
exploration and exploitation. The distribution of phenotypes along this primary
mode of variation reveals that not only the mean but also the variance varies
considerably across strains, suggesting that these nematode lineages employ
contrasting ``bet-hedging'' strategies for foraging.Comment: 46 pages, 18 figures, 6 table
Universality classes of interaction structures for NK fitness landscapes
Kauffman's NK-model is a paradigmatic example of a class of stochastic models
of genotypic fitness landscapes that aim to capture generic features of
epistatic interactions in multilocus systems. Genotypes are represented as
sequences of binary loci. The fitness assigned to a genotype is a sum of
contributions, each of which is a random function defined on a subset of loci. These subsets or neighborhoods determine the genetic interactions of
the model. Whereas earlier work on the NK model suggested that most of its
properties are robust with regard to the choice of neighborhoods, recent work
has revealed an important and sometimes counter-intuitive influence of the
interaction structure on the properties of NK fitness landscapes. Here we
review these developments and present new results concerning the number of
local fitness maxima and the statistics of selectively accessible (that is,
fitness-monotonic) mutational pathways. In particular, we develop a unified
framework for computing the exponential growth rate of the expected number of
local fitness maxima as a function of , and identify two different
universality classes of interaction structures that display different
asymptotics of this quantity for large . Moreover, we show that the
probability that the fitness landscape can be traversed along an accessible
path decreases exponentially in for a large class of interaction structures
that we characterize as locally bounded. Finally, we discuss the impact of the
NK interaction structures on the dynamics of evolution using adaptive walk
models.Comment: 61 pages, 9 figure
Who Replaces Whom? Local versus Non-local Replacement in Social and Evolutionary Dynamics
In this paper, we inspect well-known population genetics and social dynamics
models. In these models, interacting individuals, while participating in a
self-organizing process, give rise to the emergence of complex behaviors and
patterns. While one main focus in population genetics is on the adaptive
behavior of a population, social dynamics is more often concerned with the
splitting of a connected array of individuals into a state of global
polarization, that is, the emergence of speciation. Applying computational and
mathematical tools we show that the way the mechanisms of selection,
interaction and replacement are constrained and combined in the modeling have
an important bearing on both adaptation and the emergence of speciation.
Differently (un)constraining the mechanism of individual replacement provides
the conditions required for either speciation or adaptation, since these
features appear as two opposing phenomena, not achieved by one and the same
model. Even though natural selection, operating as an external, environmental
mechanism, is neither necessary nor sufficient for the creation of speciation,
our modeling exercises highlight the important role played by natural selection
in the interplay of the evolutionary and the self-organization modeling
methodologies.Comment: 14 pages, 11 figure
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