Evaluation of cardiac PET-MRI registration methods using a numerical breathing phantom

The thorax structure movements (breathing, heart motion and patient motion) during the positron emission tomography (PET) scanning cause deformations and blurring to PET scans. These artifacts are important reasons, for the mis-registration of PET volumes. In this paper, a breathing simulated PET phantom was constructed by deforming simulated (static) PET volume according to breathing model. The constructed volume was used as a ground truth in the assessment of a non-rigid registration method for cardiac MR and PET volumes. Results showed that the assessed non-rigid registration method was more accurate than a rigid registration method which was used as a reference