Hierarchical ResNeXt Models for Breast Cancer Histology Image Classification

Microscopic histology image analysis is a cornerstone in early detection of breast cancer. However these images are very large and manual analysis is error prone and very time consuming. Thus automating this process is in high demand. We proposed a hierarchical system of convolutional neural networks (CNN) that classifies automatically patches of these images into four pathologies: normal, benign, in situ carcinoma and invasive carcinoma. We evaluated our system on the BACH challenge dataset of image-wise classification and a small dataset that we used to extend it. Using a train/test split of 75%/25%, we achieved an accuracy rate of 0.99 on the test split for the BACH dataset and 0.96 on that of the extension. On the test of the BACH challenge, we've reached an accuracy of 0.81 which rank us to the 8th out of 51 teams

Machine learning methods for histopathological image analysis

Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine learning techniques. However, digital pathological images and related tasks have some issues to be considered. In this mini-review, we introduce the application of digital pathological image analysis using machine learning algorithms, address some problems specific to such analysis, and propose possible solutions.Comment: 23 pages, 4 figure

Two- and Three-Dimensional Benchmarks for Particle Detection from an Industrial Rotary Kiln Combustion Chamber Based on Light-Field-Camera Recording

This paper describes a benchmark dataset for the detection of fuel particles in 2D and 3D image data in a rotary kiln combustion chamber. The specific challenges of detecting the small particles under demanding environmental conditions allows for the performance of existing and new particle detection techniques to be evaluated. The data set includes a classification of burning and non-burning particles, which can be in the air but also on the rotary kiln wall. The light-field camera used for data generation offers the potential to develop and objectively evaluate new advanced particle detection methods due to the additional 3D information. Besides explanations of the data set and the contained ground truth, an evaluation procedure of the particle detection based on the ground truth and results for an own particle detection procedure for the data set are presented

Fine-tuning U-net for medical image segmentation based on activation function, optimizer and pooling layer

U-net convolutional neural network (CNN) is a famous architecture developed to deal with medical images. Fine-tuning CNNs is a common technique used to enhance their performance by selecting the building blocks which can provide the ultimate results. This paper introduces a method for tuning U-net architecture to improve its performance in medical image segmentation. The experiment is conducted using an x-ray image segmentation approach. The performance of U-net CNN in lung x-ray image segmentation is studied with different activation functions, optimizers, and pooling-bottleneck-layers. The analysis focuses on creating a method that can be applied for tuning U-net, like CNNs. It also provides the best activation function, optimizer, and pooling layer to enhance U-net CNN’s performance on x-ray image segmentation. The findings of this research showed that a U-net architecture worked supremely when we used the LeakyReLU activation function and average pooling layer as well as RMSProb optimizer. The U-net model accuracy is raised from 89.59 to 93.81% when trained and tested with lung x-ray images and uses the LeakyReLU activation function, average pooling layer, and RMSProb optimizer. The fine-tuned model also enhanced accuracy results with three other datasets

Evaluation of methods for detection of fluorescence labeled subcellular objects in microscope images

<p>Abstract</p> <p>Background</p> <p>Several algorithms have been proposed for detecting fluorescently labeled subcellular objects in microscope images. Many of these algorithms have been designed for specific tasks and validated with limited image data. But despite the potential of using extensive comparisons between algorithms to provide useful information to guide method selection and thus more accurate results, relatively few studies have been performed.</p> <p>Results</p> <p>To better understand algorithm performance under different conditions, we have carried out a comparative study including eleven spot detection or segmentation algorithms from various application fields. We used microscope images from well plate experiments with a human osteosarcoma cell line and frames from image stacks of yeast cells in different focal planes. These experimentally derived images permit a comparison of method performance in realistic situations where the number of objects varies within image set. We also used simulated microscope images in order to compare the methods and validate them against a ground truth reference result. Our study finds major differences in the performance of different algorithms, in terms of both object counts and segmentation accuracies.</p> <p>Conclusions</p> <p>These results suggest that the selection of detection algorithms for image based screens should be done carefully and take into account different conditions, such as the possibility of acquiring empty images or images with very few spots. Our inclusion of methods that have not been used before in this context broadens the set of available detection methods and compares them against the current state-of-the-art methods for subcellular particle detection.</p