9,014 research outputs found
Generative models of the human connectome
The human connectome represents a network map of the brain's wiring diagram
and the pattern into which its connections are organized is thought to play an
important role in cognitive function. The generative rules that shape the
topology of the human connectome remain incompletely understood. Earlier work
in model organisms has suggested that wiring rules based on geometric
relationships (distance) can account for many but likely not all topological
features. Here we systematically explore a family of generative models of the
human connectome that yield synthetic networks designed according to different
wiring rules combining geometric and a broad range of topological factors. We
find that a combination of geometric constraints with a homophilic attachment
mechanism can create synthetic networks that closely match many topological
characteristics of individual human connectomes, including features that were
not included in the optimization of the generative model itself. We use these
models to investigate a lifespan dataset and show that, with age, the model
parameters undergo progressive changes, suggesting a rebalancing of the
generative factors underlying the connectome across the lifespan.Comment: 38 pages, 5 figures + 19 supplemental figures, 1 tabl
Attention-dependent modulation of cortical taste circuits revealed by granger causality with signal-dependent noise
We show, for the first time, that in cortical areas, for example the insular, orbitofrontal, and lateral prefrontal cortex, there is signal-dependent noise in the fMRI blood-oxygen level dependent (BOLD) time series, with the variance of the noise increasing approximately linearly with the square of the signal. Classical Granger causal models are based on autoregressive models with time invariant covariance structure, and thus do not take this signal-dependent noise into account. To address this limitation, here we describe a Granger causal model with signal-dependent noise, and a novel, likelihood ratio test for causal inferences. We apply this approach to the data from an fMRI study to investigate the source of the top-down attentional control of taste intensity and taste pleasantness processing. The Granger causality with signal-dependent noise analysis reveals effects not identified by classical Granger causal analysis. In particular, there is a top-down effect from the posterior lateral prefrontal cortex to the insular taste cortex during attention to intensity but not to pleasantness, and there is a top-down effect from the anterior and posterior lateral prefrontal cortex to the orbitofrontal cortex during attention to pleasantness but not to intensity. In addition, there is stronger forward effective connectivity from the insular taste cortex to the orbitofrontal cortex during attention to pleasantness than during attention to intensity. These findings indicate the importance of explicitly modeling signal-dependent noise in functional neuroimaging, and reveal some of the processes involved in a biased activation theory of selective attention
The specificity and robustness of long-distance connections in weighted, interareal connectomes
Brain areas' functional repertoires are shaped by their incoming and outgoing
structural connections. In empirically measured networks, most connections are
short, reflecting spatial and energetic constraints. Nonetheless, a small
number of connections span long distances, consistent with the notion that the
functionality of these connections must outweigh their cost. While the precise
function of these long-distance connections is not known, the leading
hypothesis is that they act to reduce the topological distance between brain
areas and facilitate efficient interareal communication. However, this
hypothesis implies a non-specificity of long-distance connections that we
contend is unlikely. Instead, we propose that long-distance connections serve
to diversify brain areas' inputs and outputs, thereby promoting complex
dynamics. Through analysis of five interareal network datasets, we show that
long-distance connections play only minor roles in reducing average interareal
topological distance. In contrast, areas' long-distance and short-range
neighbors exhibit marked differences in their connectivity profiles, suggesting
that long-distance connections enhance dissimilarity between regional inputs
and outputs. Next, we show that -- in isolation -- areas' long-distance
connectivity profiles exhibit non-random levels of similarity, suggesting that
the communication pathways formed by long connections exhibit redundancies that
may serve to promote robustness. Finally, we use a linearization of
Wilson-Cowan dynamics to simulate the covariance structure of neural activity
and show that in the absence of long-distance connections, a common measure of
functional diversity decreases. Collectively, our findings suggest that
long-distance connections are necessary for supporting diverse and complex
brain dynamics.Comment: 18 pages, 8 figure
Fluctuations between high- and low-modularity topology in time-resolved functional connectivity
Modularity is an important topological attribute for functional brain
networks. Recent studies have reported that modularity of functional networks
varies not only across individuals being related to demographics and cognitive
performance, but also within individuals co-occurring with fluctuations in
network properties of functional connectivity, estimated over short time
intervals. However, characteristics of these time-resolved functional networks
during periods of high and low modularity have remained largely unexplored. In
this study we investigate spatiotemporal properties of time-resolved networks
in the high and low modularity periods during rest, with a particular focus on
their spatial connectivity patterns, temporal homogeneity and test-retest
reliability. We show that spatial connectivity patterns of time-resolved
networks in the high and low modularity periods are represented by increased
and decreased dissociation of the default mode network module from
task-positive network modules, respectively. We also find that the instances of
time-resolved functional connectivity sampled from within the high (low)
modularity period are relatively homogeneous (heterogeneous) over time,
indicating that during the low modularity period the default mode network
interacts with other networks in a variable manner. We confirmed that the
occurrence of the high and low modularity periods varies across individuals
with moderate inter-session test-retest reliability and that it is correlated
with previously-reported individual differences in the modularity of functional
connectivity estimated over longer timescales. Our findings illustrate how
time-resolved functional networks are spatiotemporally organized during periods
of high and low modularity, allowing one to trace individual differences in
long-timescale modularity to the variable occurrence of network configurations
at shorter timescales.Comment: Reorganized the paper; to appear in NeuroImage; arXiv abstract
shortened to fit within character limit
Complex networks: new trends for the analysis of brain connectivity
Today, the human brain can be studied as a whole. Electroencephalography,
magnetoencephalography, or functional magnetic resonance imaging techniques
provide functional connectivity patterns between different brain areas, and
during different pathological and cognitive neuro-dynamical states. In this
Tutorial we review novel complex networks approaches to unveil how brain
networks can efficiently manage local processing and global integration for the
transfer of information, while being at the same time capable of adapting to
satisfy changing neural demands.Comment: Tutorial paper to appear in the Int. J. Bif. Chao
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